Metabolite profiling of two maple-derived products using dereplication based on HPLC-DAD-ESI-TOF-MS: sugar maple bark and bud hot-water extracts.

Recent studies about hot-water extracts from sugar maple (Acer saccharum Marsh.) bark and buds demonstrated their potentials as antioxidant food additives. However, the phenolic structures responsible for the properties of these maple-derived extracts have yet to be determined. By performing HPLC-DAD-HRMS(/MS)-based dereplication, we were able to spike and classify almost 100 metabolites in each hot-water extract. Sugar maple bark hot-water extract is rich in simple phenolic compounds and phenylpropanoid derivatives while bud extract contains predominantly flavonoids, benzoic acids and their complex derivatives (condensed and hydrolysable tannins). Among those chemical structures, we tentatively identified 69 phenolic compounds that are potentially new to the genus Acer. Considering the growing commercial demand in natural products, the phenolic fingerprints of sugar maple bark and bud hot-water extracts will help promoting these two maple-derived products as new sources of bioactive compounds for food, nutraceutical and cosmetic industries.

• Publication year

  2019

• Venue

  Journal of Agricultural and Food Chemistry

• Publication date

  2019-07-19

• Fields of study

  Agricultural and Food Sciences, Medicine, Chemistry, Environmental Science

• Identifiers
  DOI 10.1021/acs.jafc.9b02664PMID 31322880
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Ultra-fast liquid chromatography coupled with electrospray ionization time-of-flight mass spectrometry for the rapid phenolic profiling of red maple (Acer rubrum) leaves.

  2018cited by this paper
• Process optimisation for pilot-scale production of maple bark extracts, natural sources of antioxidants, phenolics, and carbohydrates

  2018cited by this paper
• Nutrients, Antioxidant Capacity and Safety of Hot Water Extract from Sugar Maple (Acer saccharum M.) and Red Maple (Acer rubrum L.) Bark

  2018cited by this paper
• Hot-Water Extraction Optimization of Sugar Maple (Acer saccharum Marsh.) and Red Maple (Acer rubrum L.) Bark Applying Principal Component Analysis

  2017cited by this paper
• Liquid chromatographic/electrospray ionization quadrupole/time of flight tandem mass spectrometric study of polyphenolic composition of different Vaccinium berry species and their comparative evaluation

  2017cited by this paper
• Suitability of DPPH spiking for antioxidant screening in natural products: the example of galloyl derivatives from red maple bark extract

  2017cited by this paper
• Cosmetic applications of glucitol-core containing gallotannins from a proprietary phenolic-enriched red maple (Acer rubrum) leaves extract: inhibition of melanogenesis via down-regulation of tyrosinase and melanogenic gene expression in B16F10 melanoma cells

  2017cited by this paper
• Antioxidant Capacity, Phenolic Constituents and Toxicity of Hot Water Extract from Red Maple Buds

  2017cited by this paper
• Isolation, Identification, and Biological Evaluation of Phenolic Compounds from a Traditional North American Confectionery, Maple Sugar.

  2017cited by this paper
• Traditional uses, phytochemistry, and pharmacology of the genus Acer (maple): A review.

  2016cited by this paper
• Proanthocyanidin screening by LC-ESI-MS of Portuguese red wines made with teinturier grapes.

  2016cited by this paper
• Development and UFLC-MS/MS Characterization of a Product-Specific Standard for Phenolic Quantification of Maple-Derived Foods.

  2016cited by this paper
• Antihyperglycemic, antioxidant activities of two Acer palmatum cultivars, and identification of phenolics profile by UPLC-QTOF-MS/MS: New natural sources of functional constituents

  2016cited by this paper
• Anti-proliferative properties of commercial Pelargonium sidoides tincture, with cell-cycle G0/G1 arrest and apoptosis in Jurkat leukaemia cells

  2016cited by this paper
• Phenolic Profiling of Olives and Olive Oil Process-Derived Matrices Using UPLC-DAD-ESI-QTOF-HRMS Analysis.

  2015cited by this paper
• Qualitative and Quantitative Analysis of Lignan Constituents in Caulis Trachelospermi by HPLC-QTOF-MS and HPLC-UV

  2015cited by this paper
• Bud Extracts as New Phytochemical Source for Herbal Preparations — Quality Control and Standardization by Analytical Fingerprint

  2015cited by this paper
• Phenolic compounds: their journey after intake.

  2014cited by this paper
• Accurate Dereplication of Bioactive Secondary Metabolites from Marine-Derived Fungi by UHPLC-DAD-QTOFMS and a MS/HRMS Library

  2014cited by this paper
• Chemical Compositional, Biological, and Safety Studies of a Novel Maple Syrup Derived Extract for Nutraceutical Applications

  2014cited by this paper
• Comprehensive two-dimensional liquid chromatography tandem diode array detector (DAD) and accurate mass QTOF-MS for the analysis of flavonoids and iridoid glycosides in Hedyotis diffusa

  2014cited by this paper
• Structural elucidation of low abundant metabolites in complex sample matrices

  2013cited by this paper
• Phenolic composition and antioxidant activity of industrial cork by-products

  2013cited by this paper
• Composition of ethanolic extracts of wood and bark from Acer saccharum and Betula alleghaniensis trees of different vigor classes

  2013cited by this paper
• Identification of A-series oligomeric procyanidins from pericarp of Litchi chinensis by FT-ICR-MS and LC-MS

  2012cited by this paper
• Seasonal influence on phenolic-mediated antihyperglycemic properties of Canadian sugar and red maple leaves using in vitro assay models

  2012cited by this paper
• Acer rubrum phenolics include A-type procyanidins and a chalcone

  2012cited by this paper
• Identification and characterization of proanthocyanidins of 16 members of the Rhododendron genus (Ericaceae) by tandem LC-MS.

  2012cited by this paper
• Direct characterisation of phenolic antioxidants in infusions from four Mapuche medicinal plants by liquid chromatography with diode array detection (HPLC-DAD) and electrospray ionisation tandem mass spectrometry (HPLC-ESI–MS)

  2012cited by this paper
• Phenolic glycosides from sugar maple (Acer saccharum) bark.

  2011cited by this paper
• Differential effects of nutrient availability on the secondary metabolism of Austrian pine (Pinus nigra) phloem and resistance to Diplodia pinea

  2011cited by this paper
• Gas Chromatography/Mass Spectrometry of the Lignans in Resin of Callitris preissii

  2010cited by this paper
• Bud Dormancy and Growth

  2010cited by this paper
• Aromatic compounds and their antioxidant activity of Acer saccharum

  2010cited by this paper
• Mass spectrometry-based fragmentation as an identification tool in lignomics.

  2010cited by this paper
• Antihyperglycemic effects of Japanese maple Acer amoenum leaf extract and its constituent corilagin

  2010cited by this paper
• Global Chemome Study by LC Coupled with DAD and ESI–Q–TOF MS of a Composite Traditional Chinese Medicine Qishenyiqi Dropping Pills

  2010cited by this paper
• LC–high resolution MS in environmental analysis: from target screening to the identification of unknowns

  2010cited by this paper
• Characterization of chemopreventive agents from the dichloromethane extract of Eurycorymbus cavaleriei by liquid chromatography-ion trap mass spectrometry.

  2009cited by this paper
• High-Performance Liquid Chromatography Characterization and Identification of Antioxidant Polyphenols in Maple Syrup

  2008cited by this paper
• The Chemical Composition of Maple Syrup

  2007cited by this paper
• Antioxidant constituents from the stem ofSorghum bicolor

  2003cited by this paper
• Water-Soluble Constituents of Fennel. V. Glycosides of Aromatic Compounds.

  1998cited by this paper
• Gallotannins having a 1,5-anhydro-D-glucitol core and some ellagitannins from Acer species

  1990cited by this paper
• Methyl gallate, methyl-3,4,5-trihydroxy-benzoate, is a potent and highly specific inhibitor of herpes simplex virusin vitro. I. Purification and characterization of methyl gallate fromSapium sebiferum

  1988cited by this paper
• Phenolic glucosides from Parabenzoin praecox

  1988cited by this paper
• Phenolic Growth Inhibitors Isolated from Dormant Buds of Sugar Maple (Acer saccharum Marsh)

  1977cited by this paper
• Journal of Chromatography A

  year unknowncited by this paper

• Characterization and Variability Analysis of Volatile Metabolites From Acer saccharum Leaves From Québec Region

  2025cites this paper
• Salvia macilenta Boiss extract: phytochemical analysis, nanoformulation in Eudragit-coated liposomes and evaluation of antioxidant/inflammatory response in vitro

  2025cites this paper
• Chemotaxonomic Markers for the Leaf Buds of Common Finnish Trees and Shrubs: A Rapid UHPLC MS Fingerprinting Tool for Species Identification

  2022cites this paper
• Flavonoids quantification in Acer negundo L., extracts by hplc analysis

  2021cites this paper
• Mass spectrometry for analysis of changes during food storage and processing.

  2020cites this paper
• UPLC-ESI-MS/MS and Various Chromatographic Technique for Identification of Phytochemicals in Populus euphratica Oliv. Leaves Extract

  2020cites this paper