Ring closing metathesis strategies to isoxazole containing thiadiazepines

Cyclic sulfamides are attractive molecules with potential application in medical chemistry. It is known that thiadiazepine-containing derivatives demonstrate promising value in the development of protease inhibitors such as HIV protease, serine protease and metaloprotease. We demonstrate here a comfortable synthetic sequence to symmetric thiadiazepines containing isoxazole substitutents. The structure of the obtained substances was confirmed by 1H, 13C NMR spectroscopy.

• Publication year

  2019

• Venue

  French-Ukrainian Journal of Chemistry

• Publication date

  2019-07-30

• Fields of study

  Chemistry

• Identifiers
  DOI 10.17721/FUJCV7I1P104-112
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

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