Molecular superoxide radical photogeneration in cancer cells by dipyridophenazine iridium(iii) complexes

The switch from Type II to Type I photochemical mechanism by new Ir(iii) complexes for improved PDT of cancer under hypoxia is demonstrated.

• Publication year

  2019

• Venue

  Inorganic Chemistry Frontiers

• Publication date

  2019-09-10

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1039/C9QI00811J
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Transition metal complexes as photosensitisers in one- and two-photon photodynamic therapy

  2019cited by this paper
• Targeting G-rich DNA Structures with Photo-Reactive bis-Cyclometalated Iridium(III) Complexes.

  2019cited by this paper
• Towards Novel Photodynamic Anticancer Agents Generating Superoxide Anion Radicals: A Cyclometalated IrIII Complex Conjugated to a Far-Red Emitting Coumarin.

  2019cited by this paper
• Anticancer Cyclometalated Iridium(III) Complexes with Planar Ligands: Mitochondrial DNA Damage and Metabolism Disturbance.

  2019cited by this paper
• A Highly Luminescent Tetrahydrocurcumin IrIII Complex with Remarkable Photoactivated Anticancer Activity.

  2019cited by this paper
• Why develop photoactivated chemotherapy?

  2018cited by this paper
• Randomized Trial of Partial Gland Ablation with Vascular Targeted Phototherapy versus Active Surveillance for Low Risk Prostate Cancer: Extended Followup and Analyses of Effectiveness

  2018cited by this paper
• Transition Metal Complexes and Photodynamic Therapy from a Tumor-Centered Approach: Challenges, Opportunities, and Highlights from the Development of TLD1433.

  2018cited by this paper
• A self-assessed photosensitizer: inducing and dual-modal phosphorescence imaging of mitochondria oxidative stress.

  2018cited by this paper
• A new C,N-cyclometalated osmium(ii) arene anticancer scaffold with a handle for functionalization and antioxidative properties.

  2018cited by this paper
• Exploring the Effect of Polypyridyl Ligands on the Anticancer Activity of Phosphorescent Iridium(III) Complexes: From Proteosynthesis Inhibitors to Photodynamic Therapy Agents.

  2018cited by this paper
• Strong Influence of the Ancillary Ligand over the Photodynamic Anticancer Properties of Neutral Biscyclometalated IrIII Complexes Bearing 2-Benzoazole-Phenolates.

  2018cited by this paper
• Toxic Reactive Oxygen Species Enhanced Synergistic Combination Therapy by Self‐Assembled Metal‐Phenolic Network Nanoparticles

  2018cited by this paper
• Synthesis and characterization of cyclometallated rhodium(III) and iridium(III) compounds with antiproliferative activities in the nanomolar range

  2018cited by this paper
• Harnessing ruthenium(II) as photodynamic agents: Encouraging advances in cancer therapy

  2018cited by this paper
• Cyclometalated iridium(III) luminescent complexes in therapy and phototherapy

  2018cited by this paper
• Cyclometallated imidazo-phenanthroline iridium complexes and their anticancer activity

  2018cited by this paper
• An efficient NaHSO3-promoted protocol for chemoselective synthesis of 2-substituted benzimidazoles in water

  2018cited by this paper
• Mechanisms of action of Ru(ii) polypyridyl complexes in living cells upon light irradiation.

  2018cited by this paper
• Nucleus‐Targeted Organoiridium–Albumin Conjugate for Photodynamic Cancer Therapy

  2018cited by this paper
• Hypochlorous Acid Promoted Platinum Drug Chemotherapy by Myeloperoxidase-Encapsulated Therapeutic Metal Phenolic Nanoparticles.

  2018cited by this paper
• Near-Infrared Light-Initiated Molecular Superoxide Radical Generator: Rejuvenating Photodynamic Therapy against Hypoxic Tumors.

  2018cited by this paper
• Catch and Release Photosensitizers: Combining Dual-Action Ruthenium Complexes with Protease Inactivation for Targeting Invasive Cancers.

  2018cited by this paper
• Thiabendazole-based Rh(III) and Ir(III) biscyclometallated complexes with mitochondria-targeted anticancer activity and metal-sensitive photodynamic activity.

  2018cited by this paper
• Somatostatin receptor-targeted organometallic iridium(iii) complexes as novel theranostic agents.

  2017cited by this paper
• Organoiridium Photosensitizers Induce Specific Oxidative Attack on Proteins within Cancer Cells

  2017cited by this paper
• Taurine-modified Ru(ii)-complex targets cancerous brain cells for photodynamic therapy.

  2017cited by this paper
• Mitochondria-targeted spin-labelled luminescent iridium anticancer complexes

  2017cited by this paper
• Enhanced Cisplatin Chemotherapy by Iron Oxide Nanocarrier-Mediated Generation of Highly Toxic Reactive Oxygen Species.

  2017cited by this paper
• Critical Overview of the Use of Ru(II) Polypyridyl Complexes as Photosensitizers in One-Photon and Two-Photon Photodynamic Therapy.

  2017cited by this paper
• Photodynamic therapy in dermatology beyond non-melanoma cancer: An update.

  2017cited by this paper
• Dual Functions of Cyclometalated Iridium(III) Complexes: Anti-Metastasis and Lysosome-Damaged Photodynamic Therapy.

  2017cited by this paper
• Localization matters: a nuclear targeting two-photon absorption iridium complex in photodynamic therapy.

  2017cited by this paper
• Two-photon photodynamic ablation of tumor cells by mitochondria-targeted iridium(iii) complexes in aggregate states.

  2017cited by this paper
• Organoruthenium Complexes with C^N Ligands are Highly Potent Cytotoxic Agents that Act by a New Mechanism of Action.

  2017cited by this paper
• A NIR phosphorescent osmium(ii) complex as a lysosome tracking reagent and photodynamic therapeutic agent.

  2017cited by this paper
• Crossfire for Two-Photon Photodynamic Therapy with Fluorinated Ruthenium (II) Photosensitizers.

  2017cited by this paper
• Overcoming the Limits of Hypoxia in Photodynamic Therapy: A Carbonic Anhydrase IX-Targeted Approach.

  2017cited by this paper
• pairs with tunable emission colors for light-emitting devices and electrochromic switches †

  2016cited by this paper
• Cyclometalated Ir(iii) complexes containing quinoline-benzimidazole-based N^N ancillary ligands: structural and luminescence modulation by varying the substituent groups or the protonation/deprotonation state of imidazole units.

  2016cited by this paper
• Endoplasmic Reticulum-Localized Iridium(III) Complexes as Efficient Photodynamic Therapy Agents via Protein Modifications.

  2016cited by this paper
• Coumarin-appended phosphorescent cyclometalated iridium(iii) complexes as mitochondria-targeted theranostic anticancer agents.

  2016cited by this paper
• Highly potent extranuclear-targeted luminescent iridium(iii) antitumor agents containing benzimidazole-based ligands with a handle for functionalization.

  2016cited by this paper
• Targeting cancer cell metabolism with mitochondria-immobilized phosphorescent cyclometalated iridium(iii) complexes

  2016cited by this paper
• Monitoring the progression of cell death and the disassembly of dying cells by flow cytometry

  2016cited by this paper
• Luminescent Rhenium(I) and Iridium(III) Polypyridine Complexes as Biological Probes, Imaging Reagents, and Photocytotoxic Agents.

  2015cited by this paper
• Dual antitumor and antiangiogenic activity of organoplatinum(II) complexes.

  2015cited by this paper
• Highly Efficient Glutathione Peroxidase and Peroxiredoxin Mimetics Protect Mammalian Cells against Oxidative Damage.

  2015cited by this paper
• Design and Synthesis of Amphiphilic and Luminescent Tris-Cyclometalated Iridium(III) Complexes Containing Cationic Peptides as Inducers and Detectors of Cell Death via a Calcium-Dependent Pathway.

  2015cited by this paper
• Cyclometalated iridium( III ) complexes as lysosome-targeted photodynamic anticancer and real-time tracking agents

  2015cited by this paper
• The role of hypoxia in cancer progression, angiogenesis, metastasis, and resistance to therapy

  2015cited by this paper
• Control and utilization of ruthenium and rhodium metal complex excited states for photoactivated cancer therapy.

  2015cited by this paper
• Novel C,N-Cyclometalated Benzimidazole Ruthenium(II) and Iridium(III) Complexes as Antitumor and Antiangiogenic Agents: A Structure-Activity Relationship Study.

  2015cited by this paper
• DNA intercalating Ru(II) polypyridyl complexes as effective photosensitizers in photodynamic therapy.

  2014cited by this paper
• Copper phenanthrene oxidative chemical nucleases.

  2014cited by this paper
• Luminescent ionic transition-metal complexes for light-emitting electrochemical cells.

  2012cited by this paper
• The CH/π hydrogen bond in chemistry. Conformation, supramolecules, optical resolution and interactions involving carbohydrates.

  2011cited by this paper
• Modeling the mechanism of the glutathione peroxidase mimic ebselen.

  2011cited by this paper
• Inhibitory properties of 2-substituent-1H-benzimidazole-4-carboxamide derivatives against enteroviruses.

  2011cited by this paper
• New 7-azaindole palladium and platinum complexes: crystal structures and theoretical calculations. In vitro anticancer activity of the platinum compounds.

  2010cited by this paper
• Toward Highly Efficient Solid‐State White Light‐Emitting Electrochemical Cells: Blue‐Green to Red Emitting Cationic Iridium Complexes with Imidazole‐Type Ancillary Ligands

  2009cited by this paper
• CH/π hydrogen bonds in organic and organometallic chemistry

  2009cited by this paper
• Structure validation in chemical crystallography

  2009cited by this paper
• A highly selective luminescent switch-on probe for histidine/histidine-rich proteins and its application in protein staining.

  2008cited by this paper
• A short history of SHELX.

  2008cited by this paper
• ROS-Generating Mitochondrial DNA Mutations Can Regulate Tumor Cell Metastasis

  2008cited by this paper
• A novel metal-binding mode of thymine nucleobases: N3 and O4 chelation.

  2007cited by this paper
• Photodynamic therapy (PDT) for lung cancers.

  2006cited by this paper
• Can a single C–H⋯F–C hydrogen bond make a difference? Assessing the H⋯F bond strength from 2-D 1H-19F CP/MAS NMR

  2006cited by this paper
• From model compounds to protein binding: syntheses, characterizations and fluorescence studies of [RuII(bipy)(terpy)L]2+ complexes (bipy = 2,2'-bipyridine; terpy = 2,2':6',2''-terpyridine; L = imidazole, pyrazole and derivatives, cytochrome c).

  2005cited by this paper
• Molecular mechanisms of drug resistance

  2005cited by this paper
• Apoptosis defects and chemotherapy resistance: molecular interaction maps and networks

  2004cited by this paper
• Hematoporphyrin monomethyl ether photodynamic damage on HeLa cells by means of reactive oxygen species production and cytosolic free calcium concentration elevation.

  2004cited by this paper
• Apoptosis, Chemoresistance, and Breast Cancer: Insights From the MCF-7 Cell Model System

  2003cited by this paper
• Cell permeable ROS scavengers, Tiron and Tempol, rescue PC12 cell death caused by pyrogallol or hypoxia/reoxygenation.

  2003cited by this paper
• Expression of NAD(P)H:Quinone Oxidoreductase 1 in HeLa Cells

  2001cited by this paper
• A critical account on π–π stacking in metal complexes with aromatic nitrogen-containing ligands

  2000cited by this paper
• Tetramethyl Rhodamine Methyl Ester (TMRM) is Suitable for Cytofluorometric Measurements of Mitochondrial Membrane Potential in Cells Treated with Digitonin

  1999cited by this paper
• Identification of possible reactive oxygen species involved in ultraviolet radiation-induced oxidative DNA damage.

  1997cited by this paper
• SADABS, Program for Empirical Absorption Correction of Area Detector Data

  1996cited by this paper
• The catecholic metal sequestering agent 1,2-dihydroxybenzene-3,5-disulfonate confers protection against oxidative cell damage.

  1992cited by this paper
• QUENCHING OF SINGLET OXYGEN BY HUMAN RED CELL GHOSTS

  1991cited by this paper

• Cyclometalated iridium(III)–robustine coordination compounds as highly potent anticancer agents

  2025cites this paper
• Mechanisms of toxicity caused by bisphenol analogs in human in vitro cell models.

  2025cites this paper
• Photoactivatable, mitochondria targeting dppz iridium(III) complex selectively interacts and damages mitochondrial DNA in cancer cells.

  2024cites this paper
• Metal N-heterocyclic carbene complexes as potential metallodrugs in antitumor therapy

  2024cites this paper
• A Glance on target specific PDT active cyclometalated iridium complexes

  2024cites this paper
• Platinum iodido drugs show potential anti-tumor activity, affecting cancer cell metabolism and inducing ROS and senescence in gastrointestinal cancer cells

  2024cites this paper
• Fluorescent Diorganotin(IV) Complexes as Anticancer Agents: Study of Cytotoxicity, Cellular Localization, and Mechanism of Cell Death

  2023cites this paper
• Enhancing Catalase-Like Activity of Prussian Blue Nanozyme by Gadolinium-Doping for Imaging-Guided Antitumor Amplification via Photodynamic Therapy and Chemotherapy

  2023cites this paper
• Red-emitting heteroleptic iridium(III) complexes: photophysical and cell labeling study

  2022cites this paper
• Rational design of mitochondria targeted thiabendazole-based Ir(III) biscyclometalated complexes for a multimodal photodynamic therapy of cancer.

  2022cites this paper
• Dipyridophenazine iridium(III) complex as a phototoxic cancer stem cell selective, mitochondria targeting agent.

  2022cites this paper
• Potent anticancer activity of a novel iridium metallodrug via oncosis

  2022cites this paper
• Second and third-row transition metal compounds containing benzimidazole ligands: An overview of their anticancer and antitumour activity

  2022cites this paper
• Mitochondria-Targeted Luminescent Organotin(IV) Complexes: Synthesis, Photophysical Characterization, and Live Cell Imaging.

  2022cites this paper
• Mitochondria as a target of third row transition metal-based anticancer complexes.

  2022cites this paper
• Cyclometalated Iridium(III) Complexes as Mitochondria‐targeting Photosensitizers against Cisplatin‐resistant Cells †

  2021cites this paper
• Designing lanthanide coordination nanoframeworks as X-ray responsive radiosensitizers for efficient cancer therapy

  2021cites this paper
• A photoactivated Ir(iii) complex targets cancer stem cells and induces secretion of damage-associated molecular patterns in melanoma cells characteristic of immunogenic cell death

  2021cites this paper
• Photofunctional transition metal complexes as cellular probes, bioimaging reagents and phototherapeutics

  2021cites this paper
• Mitochondria specific highly cytoselective iridium(III)-Cp* dipyridophenazine (dppz) complexes as cancer cell imaging agents.

  2021cites this paper
• Critical discussion of the applications of metal complexes for 2-photon photodynamic therapy

  2020cites this paper
• Anticancer potency of novel organometallic Ir(iii) complexes with phosphine derivatives of fluoroquinolones encapsulated in polymeric micelles

  2020cites this paper
• Ru(ii) photosensitizers competent for hypoxic cancers via green light activation.

  2020cites this paper
• Electron‐donor substituents on the dppz‐based ligands to control luminescence from dark to bright emissive state in Ir(III) complexes

  2020cites this paper
• Metal dipyrrin complexes as potential photosensitizers for photodynamic therapy

  2020cites this paper
• X-ray tomography of cryopreserved human prostate cancer cells: mitochondrial targeting by an organoiridium photosensitiser

  2020cites this paper
• Synthesis, Characterisation and Biological Evaluation of π-Extended Fe(II) Bipyridine Complexes as Potential Photosensitizers for Photodynamic Therapy

  2020cites this paper
• Exploring the photo-toxicity of hypoxic active iridium(III)-based sensitizers in 3D tumor spheroids.

  2019cites this paper