Canescones A–E: aromatic polyketide dimers with PTP1B inhibitory activity from Penicillium canescens

Canescones A–E (1–5), aromatic polyketide dimers bearing unprecedented 5/6/6/6/5 heteropentacyclic ring skeletons with novel scaffolds, were isolated from Penicillium canescens.

• Publication year

  2019

• Venue

  Organic Chemistry Frontiers

• Publication date

  2019-09-10

• Fields of study

  Chemistry

• Identifiers
  DOI 10.1039/C9QO00820A
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Dibrefeldins A and B, A pair of epimers representing the first brefeldin A dimers with cytotoxic activities from Penicillium janthinellum.

  2019cited by this paper
• Dongtingnoids A-G: Fusicoccane Diterpenoids from a Penicillium Species.

  2019cited by this paper
• Citrofulvicin, an Antiosteoporotic Polyketide from Penicillium velutinum.

  2018cited by this paper
• Griseofamines A and B: Two Indole-Tetramic Acid Alkaloids with 6/5/6/5 and 6/5/7/5 Ring Systems from Penicillium griseofulvum.

  2018cited by this paper
• (±)-Peniorthoesters A and B, Two Pairs of Novel Spiro-Orthoester en-antiomers With an Unusual 1,4,6-Trioxaspi-ro[4.5]decane-7-One Unit From Penicillium minioluteum

  2018cited by this paper
• Collaborative Biosynthesis of Maleimide- and Succinimide-Containing Natural Products by Fungal Polyketide Megasynthases.

  2017cited by this paper
• Cascade polycyclizations in natural product synthesis.

  2016cited by this paper
• Biomimetic Synthesis of Isoindolinones Related to the Marilines

  2015cited by this paper
• Biomimetic synthesis of the calcineurin phosphatase inhibitor dibefurin.

  2014cited by this paper
• Fungal natural products in research and development.

  2014cited by this paper
• Fungal metabolites with anticancer activity.

  2014cited by this paper
• An efficient system for heterologous expression of secondary metabolite genes in Aspergillus nidulans.

  2013cited by this paper
• Drug Discovery and Natural Products: End of an Era or an Endless Frontier?

  2009cited by this paper
• The biosynthetic logic of polyketide diversity.

  2009cited by this paper
• Synthesis of the sporolide ring framework through a cascade sequence involving an intramolecular [4+2] cycloaddition reaction of an o-quinone.

  2008cited by this paper
• Structure-based optimization of protein tyrosine phosphatase 1B inhibitors: from the active site to the second phosphotyrosine binding site.

  2007cited by this paper
• PTP1B antisense oligonucleotide lowers PTP1B protein, normalizes blood glucose, and improves insulin sensitivity in diabetic mice

  2002cited by this paper
• Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene.

  1999cited by this paper
• Modulation of polyketide synthase activity by accessory proteins during lovastatin biosynthesis.

  1999cited by this paper
• Cholesterol-Lowering Drugs May Boost Bones

  1999cited by this paper

• Isolation, structural elucidation, and cytotoxicity of undescribed sesquiterpenoids and polyketides from a marine-derived fungus Talaromyces stipitatus

  2026cites this paper
• Amoenucles A-F, novel nucleoside derivatives with TNF-α inhibitory activities from Aspergillus amoenus TJ507.

  2025cites this paper
• Structurally diverse polyketides and alkaloids produced by a plant-derived fungus Penicillium canescens L1

  2025cites this paper
• Multioxidized polyketides from an endophytic Penicillium sp. YUD17006 associated with Gastrodia elata.

  2024cites this paper
• Isolation of Antagonistic Endophytic Fungi from Postharvest Chestnuts and Their Biocontrol on Host Fungal Pathogens

  2024cites this paper
• New Bioactive β-Resorcylic Acid Derivatives from the Alga-Derived Fungus Penicillium antarcticum KMM 4685

  2023cites this paper
• Structural and molecular insights of Protein Tyrosine Phosphatase 1B (PTP1B) and its inhibitors as anti-diabetic agents

  2023cites this paper
• Novel phenylacetate derivatives isolated from the fungus Penicillium canescens

  2022cites this paper
• Natural Enantiomers: Occurrence, Biogenesis and Biological Properties

  2022cites this paper
• Status of research on natural protein tyrosine phosphatase 1B inhibitors as potential antidiabetic agents: Update.

  2022cites this paper
• Multioxidized aromatic polyketides produced by a soil-derived fungus Penicillium canescens.

  2021cites this paper
• Piltunines A–F from the Marine-Derived Fungus Penicillium piltunense KMM 4668

  2019influential citation
• that may interest you

  year unknowncites this paper