Simultaneous determination of P and S in human serum, blood plasma and whole blood by ICP-MS with collision/reaction cell technology

Abstract A quantitative method was developed for the detection of phosphorus (P) and sulfur (S) in complex biological samples by inductively coupled plasma mass spectrometry (ICP-MS) with Dynamic/Reaction Cell (DRC) technology. P and S concentrations were measured at m/z 47 as PO+ and m/z 48 as SO+, respectively, in a reaction cell with oxygen (O2) to reduce the effect of polyatomic isobaric interferences at m/z 31 for P and m/z 32 for S. To correct the measured concentrations of P and S, several common internal standard elements such as Li, Sc, Rh and In were evaluated in detail for the first time. DRC mode operating conditions were optimized by changing oxygen flow rate and Rejection Parameter q (RPq). The limits of detection for P and S were as low as 0.173 μg L-1 and 1.26 μg L-1. Finally, Samples of serum, blood plasma and whole blood from healthy individuals, ten in each group, were analyzed for P and S using the proposed method. These findings can provide important reference value for diagnosis of diseases or poisoning caused by P or S disorders.

• Publication year

  2019

• Venue

  International Journal of Mass Spectrometry

• Publication date

  2019-11-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1016/J.IJMS.2019.116193
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

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