Effect of some proliferative and environmental factors on the toxicity of mitomycin C to tumor cells in vitro

No abstract is available for this paper.

• Publication year

  1986

• Venue

  International Journal of Cancer

• Publication date

  1986-08-15

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1002/ijc.2910380213PMID 3089943
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Cell Cycle Kinetics of Aerated, Hypoxic and Re‐Aerated Cells In Vitro Using Flow Cytometric Determination of Cellular Dna and Incorporated Bromodeoxyuridine

  1985cited by this paper
• Chemotherapeutic attack of hypoxic tumor cells by the bioreductive alkylating agent mitomycin C.

  1985cited by this paper
• Towards a further understanding of the growth-inhibiting action of oxygen deficiency. Evaluation of the effect of antimycin on proliferating Ehrlich ascites tumour cells.

  1985cited by this paper
• pH dependence of mitomycin C-induced cross-linking activity in EMT6 tumor cells.

  1985cited by this paper
• Enhancement of mitomycin C cytotoxicity to hypoxic tumor cells by dicoumarol in vivo and in vitro.

  1985cited by this paper
• Role of NADPH:cytochrome c reductase and DT-diaphorase in the biotransformation of mitomycin C1.

  1984cited by this paper
• Failure of 5-thio-D-glucose to alter cell survival in irradiated or unirradiated EMT6 tumors.

  1984cited by this paper
• Development of target-oriented anticancer drugs

  1984cited by this paper
• Combination therapy with misonidazole and mitomycin C: lack of chemosensitization of EMT6 tumor cells in vivo or in vitro.

  1984cited by this paper
• Aspects of the chemical stability of mitomycin and porfiromycin in acidic solution.

  1983cited by this paper
• Inhibition of cell-cycle progression by acute treatment with various degrees of hypoxia: modifications induced by low concentrations of misonidazole present during hypoxia.

  1983cited by this paper
• Deoxycytidylate shortage is a cause of G1 arrest of ascites tumor cells under oxygen deficiency

  1983cited by this paper
• Effects of extreme hypoxia on the growth and viability of EMT6/SF mouse tumor cells in vitro.

  1983cited by this paper
• Effects of mitomycin C alone and in combination with X-rays on EMT6 mouse mammary tumors in vivo.

  1983cited by this paper
• Metabolic activation of mitomycin C by liver microsomes and nuclei.

  1982cited by this paper
• Heterogeneous oxygen partial pressure and pH distribution in C3H mouse mammary adenocarcinoma.

  1981cited by this paper
• Molecular Actions and Targets for Cancer Chemotherapeutic Agents

  1981cited by this paper
• Preferential activation of mitomycin C to cytotoxic metabolites by hypoxic tumor cells.

  1980cited by this paper
• The hypoxic tumor cell: a target for selective cancer chemotherapy.

  1980cited by this paper
• Lethal and cytokinetic effects of mitomycin C on cultured human colon cancer cells.

  1980cited by this paper
• Alkylation reactions of mitomycin C at acid pH

  1979cited by this paper
• Influence of a 1400-gauss magnetic field on the radiosensitivity and recovery of EMT6 cells in vitro.

  1977cited by this paper
• In vivo-in vitro tumor systems: new models for studing the response of tumours to therapy.

  1977cited by this paper
• Studies related to antitumor antibiotics. Part VII. Synthesis of streptonigrin analogues and their single strand scission of DNA

  1976cited by this paper
• The effect of prolonged hypoxia on growth and viability of Chinese hamster cells.

  1976cited by this paper
• Studies related to antitumor antibiotics. Part V. Reactions of mitomycin C with DNA examined by ethidium fluorescence assay.

  1976cited by this paper
• CHANGES IN CELL PROLIFERATION KINETICS OCCURRING DURING THE LIFE HISTORY OF MONOLAYER CULTURES OF A MOUSE TUMOUR CELL LINE

  1975cited by this paper
• The effect of hypoxia on the growth and radiation response of mammalian cells in culture.

  1974cited by this paper
• Repair of potentially lethal damage in vivo in solid tumor cells after x-irradiation.

  1974cited by this paper
• Plateau phase in growth induced by hypoxia.

  1973cited by this paper
• Response of solid tumor cells exposed to chemotherapeutic agents in vivo: cell survival after 2- and 24-hour exposure.

  1973cited by this paper
• Potential bioreductive alkylating agents. 1. Benzoquinone derivatives.

  1972cited by this paper
• Effects of caffeine on L-cells exposed to mitomycin C.

  1970cited by this paper

• Mitomycin C hypoxic pelvic perfusion for unresectable recurrent rectal cancer: pharmacokinetic comparison of surgical and percutaneous techniques

  2017cites this paper
• The impact of hypoxia and its modification of the outcome of radiotherapy

  2016cites this paper
• Pelvic Perfusion for Rectal Cancer

  2016cites this paper
• Modulation of the tumor vasculature and oxygenation to improve therapy.

  2015cites this paper
• Beckenperfusion bei rektumkarzinomen

  2013cites this paper
• Preliminary Studies with a New Hypoxia-Selective Cytotoxin, KS119W, In Vitro and In Vivo

  2012cites this paper
• Complications and Toxicity After Abdominal and Pelvic Hypoxic Stop-Flow Perfusion Chemotherapy: Incidence and Assessment of Risk Factors

  2012cites this paper
• The Impact of Extracellular Low pH on the Anti-Tumor Efficacy Against Mesothelioma

  2012influential citation
• ROLES OF BIOTRANSFORMATION IN THE ANTITUMOUR ACTIVITY AND TOXICOLOGY OF THE HYPOXIA-ACTIVATED PRE- PRODRUG PR-104

  2010cites this paper
• Imagerie phénotypique et peptides radiomarqués au gallium-68 : au-delà des analogues de la somatostatine

  2010cites this paper
• Efavirenz Mannich bases: synthesis, anti-HIV and antitubercular activities.

  2009cites this paper
• Hypoxia and radiation therapy: past history, ongoing research, and future promise.

  2009cites this paper
• Taking advantage of tumor cell adaptations to hypoxia for developing new tumor markers and treatment strategies

  2009cites this paper
• Bioreductive drugs: from concept to clinic.

  2007cites this paper
• Regional Therapy of Rectal Cancer

  2007cites this paper
• Review: implications of in vitro research on the effect of radiotherapy and chemotherapy under hypoxic conditions.

  2007cites this paper
• Drug resistance and the solid tumor microenvironment.

  2007cites this paper
• In vitro toxicity to breast cancer cells of microsphere-delivered mitomycin C and its combination with doxorubicin.

  2006cites this paper
• PET and PET/CT in Sarcoma

  2006cites this paper
• Intra-Aortal Therapy with 5-Fluorouracil- Polyethylene Glycol Stealth Liposomes: Does the Metabolism of 5-Fluorouracil into 5-Fluoro-2′-Deoxyuridine Depend on pH Value?

  2004cites this paper
• Modulation of the antineoplastic efficacy of mitomycin C by dicoumarol in vivo

  2004cites this paper
• Efficacy of cytotoxic agents used in the treatment of testicular germ cell tumours under normoxic and hypoxic conditions in vitro

  2003influential citation
• Hypoxic pelvic and limb perfusion with melphalan and mitomycin C for recurrent limb melanoma: a pilot study

  2003cites this paper
• Combining bioreductive drugs and radiation for the treatment of solid tumors.

  2003cites this paper
• Stop-flow technique for loco-regional delivery of antiblastic agents: literature review and personal experience.

  2002cites this paper
• Deliberate hypoxic pelvic and limb chemoperfusion in the treatment of recurrent melanoma.

  2002cites this paper
• Hypoxic pelvic perfusion with mitomycin C using a simplified balloon-occlusion technique in the treatment of patients with unresectable locally recurrent rectal cancer.

  2001cites this paper
• Treatment of unresectable malignant abdominal, pelvic and thoracic tumors using abdominal pelvic and thoracic stop-flow chemotherapy.

  2001cites this paper
• Utilization of metabolic, transport and receptor-mediated processes to deliver agents for cancer diagnosis.

  1999cites this paper
• Evaluation of 64Cu-ATSM in vitro and in vivo in a hypoxic tumor model.

  1999cites this paper
• Intra-arterial infusion: overview and novel approaches.

  1998cites this paper
• Pharmacokinetics of Mitomycin C in Pelvic Stopflow Infusion and Hypoxic Pelvic Perfusion with and without Hemofiltration: A Pilot Study of Patients with Recurrent Unresectable Rectal Cancer

  1998cites this paper
• Foscan‐mediated photodynamic therapy for a peritoneal‐cancer model: Drug distribution and efficacy studies

  1997cites this paper
• Genetic instability induced by the tumor microenvironment.

  1996cites this paper
• Intraperitoneal photodynamic therapy of the rat CC531 adenocarcinoma.

  1996cites this paper
• Quantifying regional hypoxia in human tumors with positron emission tomography of [18F]fluoromisonidazole: a pretherapy study of 37 patients.

  1996cites this paper
• Pharmacokinetic studies of intraaortic stop-flow infusion with 14C-labeled mitomycin C.

  1995cites this paper
• Intraaortic stop-flow infusion: Pharmacokinetic feasibility study of regional chemotherapy for unresectable gastrointestinal cancers

  1995cites this paper
• The effect of low pH and hypoxia on the cytotoxic effects of SR4233 and mitomycin C in vitro.

  1994cites this paper
• Mitomycin C: a prototype bioreductive agent.

  1994cites this paper
• Effects of mitomycin C and porfiromycin on exponentially growing and plateau phase cultures

  1994cites this paper
• Cellular pharmacology of quinone bioreductive alkylating agents

  1993cites this paper
• Effect of treatment duration and glutathione depletion on mitomycin C cytotoxicity in vitro.

  1992cites this paper
• Use of hypoxia-directed drugs in the therapy of solid tumors.

  1992cites this paper
• Deficient activation by a human cell strain leads to mitomycin resistance under aerobic but not hypoxic conditions.

  1989cites this paper
• Modulation of the cytotoxicity of mitomycin C to EMT6 mouse mammary tumor cells by dicoumarol in vitro.

  1988cites this paper
• Oxygen and exposure kinetics as factors influencing the cytotoxicity of porfiromycin, a mitomycin C analogue, in Chinese hamster ovary cells.

  1988cites this paper
• Oxygen and Exposure Kinetics as Factors Influencing the Cytotoxicity of Porfiromycin, a Mitomycin C Analogue, in Chinese Hamster Ovary Cells

  1988cites this paper
• Hypoxic cells as specific drug targets for chemotherapy.

  1987cites this paper
• Effects of the mode of administration of mitomycin on tumor and marrow response and on the therapeutic ratio.

  1987cites this paper