Huntington’s disease: roles of huntingtin‐interacting protein 1 (HIP‐1) and its molecular partner HIPPI in the regulation of apoptosis and transcription

No abstract is available for this paper.

• Publication year

  2008

• Venue

  The FEBS Journal

• Publication date

  2008-09-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1111/j.1742-4658.2008.06563.xPMID 18637945
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Rybp interacts with Hippi and enhances Hippi-mediated apoptosis

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• Structural abnormalities in spermatids together with reduced sperm counts and motility underlie the reproductive defect in HIP1−/− mice

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• Homer1c interacts with Hippi and protects striatal neurons from apoptosis.

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• Huntingtin Interacting Proteins Are Genetic Modifiers of Neurodegeneration

  2007cited by this paper
• Huntingtin interacting protein 1 is a novel brain tumor marker that associates with epidermal growth factor receptor.

  2007cited by this paper
• NMDA Receptor Function and NMDA Receptor-Dependent Phosphorylation of Huntingtin Is Altered by the Endocytic Protein HIP1

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• Interaction of HIPPI with putative promoter sequence of caspase-1 in vitro and in vivo.

  2007cited by this paper
• Increased Caspase-2, Calpain Activations and Decreased Mitochondrial Complex II Activity in Cells Expressing Exogenous Huntingtin Exon 1 Containing CAG Repeat in the Pathogenic Range

  2007cited by this paper
• Transcriptional signatures in Huntington's disease.

  2007cited by this paper
• Interacting proteins as genetic modifiers of Huntington disease.

  2007cited by this paper
• Hippi is essential for node cilia assembly and Sonic hedgehog signaling.

  2006cited by this paper
• Current concepts in apoptosis: The physiological suicide program revisited

  2006cited by this paper
• Huntingtin‐interacting protein 1‐mediated neuronal cell death occurs through intrinsic apoptotic pathways and mitochondrial alterations

  2006cited by this paper
• Selective neuronal degeneration in Huntington's disease.

  2006cited by this paper
• Induction of apoptosis in cells expressing exogenous Hippi, a molecular partner of huntingtin-interacting protein Hip1.

  2006cited by this paper
• Huntingtin interacting protein 1 modulates the transcriptional activity of nuclear hormone receptors

  2005cited by this paper
• Caspase-1 is a direct target gene of ETS1 and plays a role in ETS1-induced apoptosis.

  2005cited by this paper
• Regulation of the proapoptotic activity of huntingtin interacting protein 1 by Dyrk1 and caspase‐3 in hippocampal neuroprogenitor cells

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• Expression pattern of apoptosis-related markers in Huntington’s disease

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• Role of p73 in Regulating Human Caspase-1 Gene Transcription Induced by Interferon-γ and Cisplatin*

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• Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death

  2004cited by this paper
• A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease.

  2004cited by this paper
• Huntingtin-protein interactions and the pathogenesis of Huntington's disease.

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• HIP1: trafficking roles and regulation of tumorigenesis.

  2004cited by this paper
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  2003cited by this paper
• The viral death protein Apoptin interacts with Hippi, the protein interactor of Huntingtin-interacting protein 1.

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• The hunt for huntingtin function: interaction partners tell many different stories.

  2003cited by this paper
• Disruption of the endocytic protein HIP1 results in neurological deficits and decreased AMPA receptor trafficking

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• Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi

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• Regulation of Gli1 Transcriptional Activity in the Nucleus by Dyrk1*

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• Huntingtin-interacting protein 1 is overexpressed in prostate and colon cancer and is critical for cellular survival.

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• Huntingtin Interacting Protein 1 Is a Clathrin Coat Binding Protein Required for Differentiation of late Spermatogenic Progenitors

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• Loss of normal huntingtin function: new developments in Huntington's disease research.

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• Direct Transcriptional Activation of Human Caspase-1 by Tumor Suppressor p53*

  2001cited by this paper
• Onset and pre-onset studies to define the Huntington's disease natural history.

  2001cited by this paper
• Huntingtin Interacting Protein 1 Induces Apoptosis via a Novel Caspase-dependent Death Effector Domain*

  2000cited by this paper
• Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's disease

  1999cited by this paper
• RYBP, a new repressor protein that interacts with components of the mammalian Polycomb complex, and with the transcription factor YY1

  1999cited by this paper
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  1997cited by this paper
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  1997cited by this paper

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• Silencing HIPPI Suppresses Tumor Progression in Non-Small-Cell Lung Cancer by Inhibiting DNA Replication

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