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PEO-chitosan nanofibers containing carboxymethyl-hexanoyl chitosan/dodecyl sulfate nanoparticles loaded with pyrazoline for skin cancer treatment

Andrés Felipe Chamorro Rengifo,N. Stefanes,Jéssica Toigo,Cassiana Mendes,D. Argenta,M. Dotto,Maria Cláudia Santos da Silva,R. Nunes,Thiago Caon,A. Parize,Edson Minatti

Published 2019 in European Polymer Journal

ABSTRACT

Abstract Intact carboxymethyl-hexanoyl chitosan/dodecyl sulfate nanoparticles loaded with pyrazoline H3TM04 were dispersed in biodegradable PEO-chitosan nanofiber mats (PEOChNps) for application in skin cancer treatment. The nanomaterial was formed by co-electrospinning in aqueous solution. The structural and morphological properties of the PEOChNps were investigated by FEG-SEM, TEM, AFM, FTIR, DSC and TGA. The PEOChNps nanofibers showed a narrow size distribution (197.8 ± 4.1 nm) with a homogenous distribution of the nanoparticles inside the nanofibers, promoting the controlled release of H3TM04 from both diffusion and erosion processes over a period of 120 h. An increased transport rate of H3TM04 through the epidermis was also found when PEOChNps was used as the carrier. In in vitro cytotoxicity assays, the incorporation of H3TM04 into the nanocarriers increased its cytotoxic effect toward B16F10 melanoma cells. These findings suggest that the proposed nanofiber mats could be used for controlled drug release in local chemotherapy treatment for skin cancer.

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