Gabapentin-lactam, a close analogue of the anticonvulsant gabapentin, exerts convulsant activity in amygdala kindled rats

No abstract is available for this paper.

• Publication year

  2000

• Venue

  Naunyn-Schmiedeberg's Archives of Pharmacology

• Publication date

  2000-01-17

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1007/s002109900174PMID 10685877
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Pharmacology of glutamate receptor antagonists in the kindling model of epilepsy.

  1998cited by this paper
• A summary of mechanistic hypotheses of gabapentin pharmacology.

  1998cited by this paper
• Mechanisms of action of gabapentin.

  1997cited by this paper
• Comparison of the preclinical anticonvulsant profiles of tiagabine, lamotrigine, gabapentin and vigabatrin.

  1997cited by this paper
• The anticonvulsant gabapentin decreases firing rates of substantia nigra pars reticulata neurons.

  1996cited by this paper
• Basic mechanisms of seizure propagation: targets for rational drug design and rational polypharmacy.

  1996cited by this paper
• The effect of gabapentin on brain gamma‐aminobutyric acid in patients with epilepsy

  1996cited by this paper
• Anticonvulsant and antiepileptogenic effect of L-deprenyl (selegiline) in the kindling model of epilepsy.

  1995cited by this paper
• Gabapentin: mechanisms of action

  1995cited by this paper
• Kindling Increases the Sensitivity of Rats to Adverse Effects of Certain Antiepileptic Drugs

  1995influential reference
• The anticonvulsant gabapentin enhances promoted release of GABA in hippocampus: a field potential analysis.

  1995cited by this paper
• Low Doses of the Glycine/NMDA Receptor Antagonist R‐(+)‐HA‐966 but not d‐Cycloserine Induce Paroxysmal Activity in Limbic Brain Regions of Kindled Rats

  1994cited by this paper
• Strategies in antiepileptic drug development: is rational drug design superior to random screening and structural variation?

  1994cited by this paper
• Gabapentin anticonvulsant action in rats: disequilibrium with peak drug concentrations in plasma and brain microdialysate.

  1993cited by this paper
• Effects of gabapentin on release of gamma-aminobutyric acid from slices of rat neostriatum.

  1993cited by this paper
• Adenosine: A potential mediator of seizure arrest and postictal refractoriness

  1992cited by this paper
• Lack of changes in seizure susceptibility during the estrous cycle in kindled rats.

  1992cited by this paper
• Gabapentin increases aminooxyacetic acid-induced GABA accumulation in several regions of rat brain.

  1991cited by this paper
• Responses to NMDA receptor antagonists altered by epileptogenesis.

  1991cited by this paper
• High doses of memantine (1-amino-3,5-dimethyladamantane) induce seizures in kindled but not in non-kindled rats

  1990cited by this paper
• Phenytoin potently increases the threshold for focal seizures in amygdala-kindled rats.

  1990cited by this paper
• Changes in γ‐Aminobutyric Acid Biochemistry and Seizure Threshold

  1986cited by this paper
• Adenosine: the brain's natural anticonvulsant?

  1986cited by this paper
• Changes in gamma-aminobutyric acid biochemistry and seizure threshold.

  1986cited by this paper
• The effect of interstimulation interval on the assessment and stability of kindled seizure thresholds.

  1981cited by this paper
• Postseizure inhibition of kindled seizures.

  1977cited by this paper
• Modification of seizure activity by electrical stimulation. II. Motor seizure.

  1972cited by this paper
• [Pharmacology of a new group of central stimulating substances].

  1960cited by this paper

• Microwave-Assisted Organic Synthesis: An Eco-Friendly Method of Green Chemistry

  2025cites this paper
• Recent advances in microwave-assisted multicomponent synthesis of spiro heterocycles

  2024cites this paper
• Cucurbit[7]uril Complexes with Gabapentin: Effect on Lactamization

  2023cites this paper
• Microwave produced 8-methyl-1,2,4,8-tetraazaspiro[4.5]dec-2-en-3-amine derivatives: their in vitro and in silico analysis

  2023cites this paper
• A preliminary assessment of pregabalin lactam mutagenicity and remarks on “An investigation of pregabalin lactamization process and effect of various pH on reaction: A computational insight”

  2021cites this paper
• Investigating the Mechanism of l-Valine in Improving the Stability of Gabapentin Combining Chemical Analysis Experiments with Computational Pharmacy

  2019cites this paper
• Evaluation of antiseizure drug efficacy and tolerability in the rat lamotrigine‐resistant amygdala kindling model

  2019cites this paper
• Biotransformation of gabapentin in surface water matrices under different redox conditions and the occurrence of one major TP in the aquatic environment.

  2018cites this paper
• Identification of phototransformation products of the antiepileptic drug gabapentin: Biodegradability and initial assessment of toxicity.

  2015cites this paper
• Studying epilepsy to understand bipolar disorder?

  2015cites this paper
• Formulation of a modified-release pregabalin tablet using hot-melt coating with glyceryl behenate.

  2015cites this paper
• Development of a kinetic model to investigate the effect of compositional variation and a processing condition on the solid-state degradation of gabapentin

  2015cites this paper
• Benzotriazole-Based Strategies Toward Peptidomimetics, Conjugates, and Other Peptide Derivatives

  2015cites this paper
• Investigating psychotropic properties of antiepileptic drugs

  2013cites this paper
• The application of first principle modeling in combination with empirical design of experiments and real-time data management for the automated control of pharmaceutical operations

  2012cites this paper
• Development of a Statistical Tolerance-Based Fluid Bed Drying Design Space

  2012cites this paper
• On the Track of New Multicomponent Gabapentin Crystal Forms: Synthon Competition and pH Stability

  2011cites this paper
• Spinacia oleracea retards the development of Amygdala kindled epilepsy in rats

  2011cites this paper
• Biotechnology: Pharmaceutical Aspects

  2010cites this paper
• Stability of Repackaged Products

  2010cites this paper
• Stability of gabapentin 300-mg capsules repackaged in unit dose containers.

  2009cites this paper
• Rapid examination of the kinetic process of intramolecular lactamization of gabapentin using DSC–FTIR

  2009cites this paper
• Polymorphic gabapentin: thermal behaviour, reactivity and interconversion of forms in solution and solid-state

  2008cites this paper
• Mechanistic investigation on 2-aza-spiro[4,5]decan-3-one formation from 1-(aminomethyl)cyclohexylacetic acid (gabapentin)

  2008cites this paper
• Comparison of the stability of split and intact gabapentin tablets.

  2008cites this paper
• Development and application of a validated HPLC method for the determination of gabapentin and its major degradation impurity in drug products.

  2007cites this paper
• Gabapentin in horses: validation of an analytical method for gabapentin quantitation.

  2007cites this paper
• Life‐Threatening Status Epilepticus Following Gabapentin Administration in a Patient with Benign Adult Familial Myoclonic Epilepsy

  2007cites this paper
• Gabapentin-Lactam Induces Dendritic Filopodia and Motility in Cultured Hippocampal Neurons

  2006cites this paper
• Gabapentin-lactam, but not gabapentin, reduces protein aggregates and improves motor performance in a transgenic mouse model of Huntington’s disease

  2004cites this paper
• Dendritic polyglycerol as a high-loading support for parallel multistep synthesis of GABA lactam analogues

  2004cites this paper
• XP13512 aminomethyl)-1-cyclohexane Acetic Acid], A Novel Gabapentin Prodrug: I. Design, Synthesis, Enzymatic Conversion to Gabapentin, and Transport by Intestinal Solute Transporters

  2004cites this paper
• XP13512 [(±)-1-([(α-Isobutanoyloxyethoxy)carbonyl] aminomethyl)-1-cyclohexane Acetic Acid], A Novel Gabapentin Prodrug: I. Design, Synthesis, Enzymatic Conversion to Gabapentin, and Transport by Intestinal Solute Transporters

  2004cites this paper
• Preferential action of gabapentin and pregabalin at P/Q‐type voltage‐sensitive calcium channels: Inhibition of K+‐evoked [3H]‐norepinephrine release from rat neocortical slices

  2002cites this paper
• Myoclonus in Epilepsy Patients with Anticonvulsive Add‐On Therapy with Pregabalin

  2001cites this paper