Activation of Progelatinase A by Mammalian Legumain, a Recently Discovered Cysteine Proteinase

No abstract is available for this paper.

• Publication year

  2001

• Venue

  Unknown venue

• Publication date

  Unknown publication date

• Fields of study

  Not labeled

• Identifiers
  DOI 10.1515/bchm.2001.382.5.777
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Activation of human prolegumain by cleavage at a C-terminal asparagine residue.

  2000influential reference
• Matrix metalloproteinase-2 is required for the switch to the angiogenic phenotype in a tumor model.

  2000cited by this paper
• Control of antigen presentation by a single protease cleavage site.

  2000cited by this paper
• Matrix metalloproteinase 2 (gelatinase A) is related to migration of keratinocytes.

  1999cited by this paper
• Inhibition of Mammalian Legumain by Some Cystatins Is Due to a Novel Second Reactive Site*

  1999cited by this paper
• Pig kidney legumain: an asparaginyl endopeptidase with restricted specificity.

  1999cited by this paper
• Reduced angiogenesis and tumor progression in gelatinase A-deficient mice.

  1998cited by this paper
• Identification of the active site of legumain links it to caspases, clostripain and gingipains in a new clan of cysteine endopeptidases

  1998cited by this paper
• Sorting of Non-Glycosylated Human Procathepsin S in Mammalian Cells

  1998cited by this paper
• Does an asparaginyl-specific cysteine endopeptidase trigger phaseolin degradation in cotyledons of kidney bean seedlings?

  1998cited by this paper
• Plasma Membrane-bound Tissue Inhibitor of Metalloproteinases (TIMP)-2 Specifically Inhibits Matrix Metalloproteinase 2 (Gelatinase A) Activated on the Cell Surface*

  1998cited by this paper
• Vacuolar processing enzymes in protein-storage vacuoles and lytic vacuoles

  1998cited by this paper
• Cloning and expression of mouse legumain, a lysosomal endopeptidase.

  1998cited by this paper
• An asparaginyl endopeptidase processes a microbial antigen for class II MHC presentation

  1998cited by this paper
• Cloning, Isolation, and Characterization of Mammalian Legumain, an Asparaginyl Endopeptidase*

  1997cited by this paper
• Intracellular activation of gelatinase A (72-kDa type IV collagenase) by normal fibroblasts.

  1997cited by this paper
• Activation of Progelatinase A and Progelatinase A/TIMP-2 Complex by Membrane Type 2-Matrix Metalloproteinase

  1997cited by this paper
• Activation of gelatinase A (72-kDa type IV collagenase) induced by monensin in normal human fibroblasts.

  1997cited by this paper
• An aspartic endopeptidase is involved in the breakdown of propeptides of storage proteins in protein-storage vacuoles of plants.

  1997cited by this paper
• Activation mechanisms of matrix metalloproteinases.

  1997cited by this paper
• The Soluble Catalytic Domain of Membrane Type 1 Matrix Metalloproteinase Cleaves the Propeptide of Progelatinase A and Initiates Autoproteolytic Activation

  1996cited by this paper
• Steps involved in activation of the complex of pro-matrix metalloproteinase 2 (progelatinase A) and tissue inhibitor of metalloproteinases (TIMP)-2 by 4-aminophenylmercuric acetate.

  1995cited by this paper
• Vacuolar Processing Enzyme Responsible for Maturation of Seed Proteins

  1995cited by this paper
• Reconstructed 19 kDa catalytic domain of gelatinase A is an active proteinase.

  1995cited by this paper
• Isolation and analysis of cDNA encoding a precursor of Canavalia ensiformis asparaginyl endopeptidase (legumain).

  1994cited by this paper
• The two cysteine endopeptidases of legume seeds: purification and characterization by use of specific fluorometric assays.

  1993cited by this paper
• Molecular characterization of a vacuolar processing enzyme related to a putative cysteine proteinase of Schistosoma mansoni.

  1993cited by this paper
• A novel coumarin‐labelled peptide for sensitive continuous assays of the matrix metalloproteinases

  1992cited by this paper
• Isolation and characterization of a 70-kDa metalloprotease (gelatinase) that is elevated in Rous sarcoma virus-transformed chicken embryo fibroblasts.

  1991cited by this paper
• FLUSYS: a software package for the collection and analysis of kinetic and scanning data from Perkin-Elmer fluorimeters

  1990cited by this paper
• Definition of the complete Schistosoma mansoni hemoglobinase mRNA sequence and gene expression in developing parasites.

  1990cited by this paper
• Detergent-activation of latent collagenase and resolution of its component molecules.

  1982cited by this paper
• Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

  1970cited by this paper

• Asparagine endopeptidase cleaves apolipoprotein A1 and accelerates pathogenesis of atherosclerosis

  2025cites this paper
• Non-Canonical, Extralysosomal Activities of Lysosomal Peptidases in Physiological and Pathological Conditions: New Clinical Opportunities for Cancer Therapy

  2025cites this paper
• Association between high plasma levels of legumain and cardiovascular events in patients undergoing coronary angiography

  2024cites this paper
• Towards imaging the immune state of cancer by PET: Targeting legumain with 11C-labeled P1-Asn peptidomimetics carrying a cyano-warhead.

  2024cites this paper
• Legumain inhibitor prevents breast cancer bone metastasis by attenuating osteoclast differentiation and function.

  2023cites this paper
• Autocrine pro-legumain promotes breast cancer metastasis via binding to integrin αvβ3

  2022cites this paper
• Fetal Programming of the Endocrine Pancreas: Impact of a Maternal Low-Protein Diet on Gene Expression in the Perinatal Rat Pancreas

  2022cites this paper
• Metformin regulates autophagy via LGMN to inhibit choriocarcinoma.

  2022cites this paper
• Asparaginyl endopeptidase protects against podocyte injury in diabetic nephropathy through cleaving cofilin-1

  2022cites this paper
• Active legumain promotes invasion and migration of neuroblastoma by regulating epithelial-mesenchymal transition

  2022cites this paper
• The Mammalian Cysteine Protease Legumain in Health and Disease

  2022cites this paper
• The Mechanism of Asparagine Endopeptidase in the Progression of Malignant Tumors: A Review

  2021cites this paper
• Legumain is a predictor of all-cause mortality and potential therapeutic target in acute myocardial infarction

  2020cites this paper
• Legumain in cardiovascular disease: Culprit or ally?

  2020cites this paper
• Identifying Cell-Type Specific Genes and Expression Rules Based on Single-Cell Transcriptomic Atlas Data

  2020cites this paper
• Legumain promotes fibrogenesis in chronic pancreatitis via activation of transforming growth factor β1

  2020cites this paper
• High Level of Legumain Was Correlated With Worse Prognosis and Peritoneal Metastasis in Gastric Cancer Patients

  2020cites this paper
• The LGMN pseudogene promotes tumor progression by acting as a miR-495-3p sponge in glioblastoma.

  2020cites this paper
• Legumain in Acute Coronary Syndromes: A Substudy of the PLATO (Platelet Inhibition and Patient Outcomes) Trial

  2020cites this paper
• Modifications of extracellular matrix features in the left and right uterine horns during the embryo pre-implantation period in Vicugna pacos.

  2020cites this paper
• Esomeprazole inhibits the lysosomal cysteine protease legumain to prevent cancer metastasis

  2020cites this paper
• Proteomic study of endothelial dysfunction in response to homocysteinylated albumin

  2019cites this paper
• Legumain is upregulated in acute cardiovascular events and associated with improved outcome - potentially related to anti-inflammatory effects on macrophages.

  2019cites this paper
• Design of a New Peptide Substrate Probe of the Putative Biomarker Legumain with Potential Application in Prostate Cancer Diagnosis Ex Vivo

  2019cites this paper
• Mammalian legumain - A lysosomal cysteine protease with extracellular functions?

  2019cites this paper
• Macrophage-Derived Legumain Promotes Pulmonary Hypertension by Activating the MMP (Matrix Metalloproteinase)-2/TGF (Transforming Growth Factor)-&bgr;1 Signaling

  2019cites this paper
• Legumain is an independent predictor for invasive recurrence in breast ductal carcinoma in situ

  2018cites this paper