Adult Hepatic Progenitor Cell Niche: How it affects the Progenitor Cell Fate

The hepatic progenitor cell (HPC) niche is a special microenvironment composed of different cell types, extracellular matrix (ECM) components, growth factors and cytokines released by the niche cells that help to maintain the characteristics of HPCs and the balance between their activation, proliferation and differentiation. Composition of this special microenvironment, created in response to specific liver damage, together with critical interactions between different partners of the HPC niche can determine the fate decision and differentiation pathways of HPCs. A number of recent studies have shed light on factors and signals from the HPC niche that determines the choice of HPCs differentiation towards a specific cell type depending on the nature of the liver injury and resultant microenvironment created by this injury. This paper seeks to provide an in-depth review, through a literature review and the authors’ experiences, of the most recent findings on the role of the HPC niche in fate choice option of HPCs toward either hepatocytes or bile duct epithelial cells and its clinical relevance.

• Publication year

  2014

• Venue

  Middle East Journal of Digestive Diseases

• Publication date

  2014-04-01

• Fields of study

  Biology, Medicine

• Identifiers
  PMID 24872864PMCID 4034666
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Failure of fibrotic liver regeneration in mice is linked to a severe fibrogenic response driven by hepatic progenitor cell activation.

  2013cited by this paper
• Liver regeneration.

  2012cited by this paper
• Intrahepatic cholangiocarcinoma can arise from Notch-mediated conversion of hepatocytes.

  2012cited by this paper
• Liver progenitor cells yield functional hepatocytes in response to chronic liver injury in mice.

  2012cited by this paper
• The microenvironment in hepatocyte regeneration and function in rats with advanced cirrhosis

  2012cited by this paper
• Cholangiocarcinomas can originate from hepatocytes in mice.

  2012cited by this paper
• Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease

  2012cited by this paper
• Noncanonical Wnt signaling maintains hematopoietic stem cells in the niche.

  2012cited by this paper
• Kupffer cells influence parenchymal invasion and phenotypic orientation, but not the proliferation, of liver progenitor cells in a murine model of liver injury.

  2011cited by this paper
• Continuous cell supply from a Sox9-expressing progenitor zone in adult liver, exocrine pancreas and intestine

  2011cited by this paper
• Characterisation of a stereotypical cellular and extracellular adult liver progenitor cell niche in rodents and diseased human liver

  2010cited by this paper
• Small molecule antagonists of Tcf4/β‐catenin complex inhibit the growth of HCC cells in vitro and in vivo

  2010cited by this paper
• Tumor necrosis factor–like weak inducer of apoptosis is a mitogen for liver progenitor cells

  2010cited by this paper
• Remodelling of extracellular matrix is a requirement for the hepatic progenitor cell response

  2010cited by this paper
• The isolation and in vitro expansion of hepatic Sca-1 progenitor cells.

  2009cited by this paper
• Characterisation of the liver progenitor cell niche in liver diseases: potential involvement of Wnt and Notch signalling

  2009cited by this paper
• Expression of stromal-cell-derived factor-1 on circulating platelets is increased in patients with acute coronary syndrome and correlates with the number of CD34+ progenitor cells.

  2009cited by this paper
• Relation between liver progenitor cell expansion and extracellular matrix deposition in a CDE‐induced murine model of chronic liver injury

  2009cited by this paper
• Liver stem cells and hepatocellular carcinoma

  2009cited by this paper
• The hepatic stem cell niche: Identification by label‐retaining cell assay

  2008cited by this paper
• Wnt signaling in the niche enforces hematopoietic stem cell quiescence and is necessary to preserve self-renewal in vivo.

  2008cited by this paper
• What fires prometheus? The link between inflammation and regeneration following chronic liver injury.

  2008cited by this paper
• Stem cells and niches: mechanisms that promote stem cell maintenance throughout life.

  2008cited by this paper
• Accumulation of hedgehog-responsive progenitors parallels alcoholic liver disease severity in mice and humans.

  2008cited by this paper
• No place like home: anatomy and function of the stem cell niche

  2008cited by this paper
• Lymphocytes Support Oval Cell-Dependent Liver Regeneration1

  2008cited by this paper
• Activation of stem cells in hepatic diseases

  2007cited by this paper
• Bile ductules and stromal cells express hedgehog ligands and/or hedgehog target genes in primary biliary cirrhosis

  2007cited by this paper
• The stem-cell niche as an entity of action

  2006cited by this paper
• Epidermal stem cells of the skin.

  2006cited by this paper
• Hedgehog signaling maintains resident hepatic progenitors throughout life.

  2006cited by this paper
• Liver stem cells and their implication in hepatocellular and cholangiocarcinoma

  2006cited by this paper
• Liver regeneration

  2006cited by this paper
• Liver regeneration in acute severe liver impairment: a clinicopathological correlation study

  2006cited by this paper
• Maintenance of the hematopoietic stem cell pool by CXCL12-CXCR4 chemokine signaling in bone marrow stromal cell niches.

  2006cited by this paper
• Progenitor cells in liver regeneration: molecular responses controlling their activation and expansion

  2005cited by this paper
• Expression of oncostatin M and its receptors in normal and cirrhotic human liver.

  2005cited by this paper
• Liver inflammation and cytokine production, but not acute phase protein synthesis, accompany the adult liver progenitor (oval) cell response to chronic liver injury

  2005cited by this paper
• Self-Renewal and Cancer of the Gut: Two Sides of a Coin

  2005cited by this paper
• Fibrosis correlates with a ductular reaction in hepatitis C: Roles of impaired replication, progenitor cells and steatosis

  2005cited by this paper
• TWEAK induces liver progenitor cell proliferation.

  2005cited by this paper
• Stem cell niche: structure and function.

  2005cited by this paper
• Liver regeneration: from myth to mechanism

  2004cited by this paper
• Liver regeneration and repair: Hepatocytes, progenitor cells, and stem cells

  2004cited by this paper
• Nomenclature of the finer branches of the biliary tree: Canals, ductules, and ductular reactions in human livers

  2004cited by this paper
• Liver extracellular matrix in health and disease

  2003cited by this paper
• Oxidative stress and oval cell accumulation in mice and humans with alcoholic and nonalcoholic fatty liver disease.

  2003cited by this paper
• Regeneration of hepatocyte 'buds' in cirrhosis from intrabiliary stem cells.

  2003cited by this paper
• Stromal Cell–Derived Factor-1 from Biliary Epithelial Cells Recruits CXCR4-Positive Cells: Implications for Inflammatory Liver Diseases

  2003cited by this paper
• Progenitor cell involvement in cirrhotic human liver diseases: from controversy to consensus.

  2003cited by this paper
• Interleukin 6/gp130‐dependent pathways are protective during chronic liver diseases

  2003cited by this paper
• Progenitor cells in diseased human liver.

  2003cited by this paper
• Small epithelial cells in human liver cirrhosis exhibit features of hepatic stem‐like cells: immunohistochemical, electron microscopic and immunoelectron microscopic findings

  2003cited by this paper
• SDF-1α/CXCR4: A Mechanism for Hepatic Oval Cell Activation and Bone Marrow Stem Cell Recruitment to the Injured Liver of Rats

  2002cited by this paper
• Heterogeneity and plasticity of hepatocyte lineage cells

  2001cited by this paper
• Expression of neural cell adhesion molecule in human liver development and in congenital and acquired liver diseases

  2001cited by this paper
• Deep intralobular extension of human hepatic ‘progenitor cells’ correlates with parenchymal inflammation in chronic viral hepatitis: can ‘progenitor cells’ migrate?

  2000cited by this paper
• Sequential Observation of Liver Cell Regeneration after Massive Hepatic Necrosis in Auxiliary Partial Orthotopic Liver Transplantation

  2000cited by this paper
• Characterization and isolation of ductular cells coexpressing neural cell adhesion molecule and Bcl-2 from primary cholangiopathies and ductal plate malformations.

  2000cited by this paper
• Oval cell numbers in human chronic liver diseases are directly related to disease severity.

  1999cited by this paper
• Hepatic OV-6 expression in human liver disease and rat experiments: evidence for hepatic progenitor cells in man.

  1998cited by this paper
• Liver stem cells: a two compartment system.

  1998cited by this paper
• Comparison of liver progenitor cells in human atypical ductular reactions with those seen in experimental models of liver injury

  1998cited by this paper
• Identification of bipotential progenitor cells in human liver regeneration.

  1996cited by this paper
• Ductular reaction after submassive necrosis in humans. Special emphasis on analysis of ductular hepatocytes.

  1996cited by this paper
• Auxiliary partial orthotopic liver transplantation for fulminant hepatitis. The Paul Brousse experience.

  1996cited by this paper
• Auxiliary liver transplantation: Regeneration of the native liver and outcome in 30 patients with fulminant hepatic failure–a multicenter European study

  1996cited by this paper
• Auxiliary liver transplantation for fulminant and subfulminant hepatic failure.

  1995cited by this paper
• Auxiliary partial orthotopic liver transplantation for acute liver failure: the Hannover experience.

  1994cited by this paper
• Auxiliary partial orthotopic liver transplantation (APOLT) for fulminant hepatic failure: First successful case report

  1991cited by this paper
• The relationship between the spleen colony-forming cell and the haemopoietic stem cell.

  1978cited by this paper

• Novel approach for reconstruction of the three-dimensional biliary system in decellularized liver scaffold using hepatocyte progenitors

  2024cites this paper
• Liver Progenitor Cells in Massive Hepatic Necrosis—How Can a Patient Survive Acute Liver Failure?

  2022cites this paper
• Re-Recognizing the Cellular Origin of the Primary Epithelial Tumors of the Liver

  2021cites this paper
• Myofibroblast induces hepatocyte-to-ductal metaplasia via laminin–ɑvβ6 integrin in liver fibrosis

  2020cites this paper
• Understanding the marvels behind liver regeneration

  2019cites this paper
• Mir-382 Promotes Differentiation of Rat Liver Progenitor Cell WB-F344 by Targeting Ezh2

  2018cites this paper
• The diversity and plasticity of adult hepatic progenitor cells and their niche

  2017cites this paper
• Lipopolysaccharide induces the differentiation of hepatic progenitor cells into myofibroblasts via activation of the Hedgehog signaling pathway

  2017cites this paper
• Characterisation of liver progenitor cells and their microenvironment during chronic liver disease and hepatocarcinogenesis

  2016cites this paper
• Hepatic metastatic niche: from normal to pre-metastatic and metastatic niche

  2016cites this paper
• Selective internal radiation therapy in treatment of hepatocellular carcinoma: new concepts of personalization.

  2016cites this paper
• Upregulation of hydroxysteroid sulfotransferase 2B1b promotes hepatic oval cell proliferation by modulating oxysterol-induced LXR activation in a mouse model of liver injury

  2016influential citation
• TGF-β1 Induces the Dual Regulation of Hepatic Progenitor Cells with Both Anti- and Proliver Fibrosis

  2015cites this paper
• Perfil circadiano da expressão de microRNAs em células

  2014cites this paper