Structure and Function of a C-C Bond Cleaving Oxygenase in Atypical Angucycline Biosynthesis.

No abstract is available for this paper.

• Publication year

  2017

• Venue

  ACS Chemical Biology

• Publication date

  2017-01-20

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1021/acschembio.6b00621PMID 28103689
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Crystal Structures of SgcE6 and SgcC, the Two-Component Monooxygenase That Catalyzes Hydroxylation of a Carrier Protein-Tethered Substrate during the Biosynthesis of the Enediyne Antitumor Antibiotic C-1027 in Streptomyces globisporus

  2016cited by this paper
• Kinamycin biosynthesis employs a conserved pair of oxidases for B-ring contraction.

  2015cited by this paper
• Genome Sequence of the Mycorrhiza Helper Bacterium Streptomyces sp. Strain AcH 505

  2015cited by this paper
• Heterologous Expression of Fluostatin Gene Cluster Leads to a Bioactive Heterodimer.

  2015cited by this paper
• Discovery of the lomaiviticin biosynthetic gene cluster in Salinispora pacifica.

  2014cited by this paper
• MEGA6: Molecular Evolutionary Genetics Analysis version 6.0.

  2013cited by this paper
• Insights into lomaiviticin biosynthesis. Isolation and structure elucidation of (-)-homoseongomycin.

  2013cited by this paper
• Bioactivity‐Guided Genome Mining Reveals the Lomaiviticin Biosynthetic Gene Cluster in Salinispora tropica

  2013cited by this paper
• Fluostatins I-K from the South China Sea-derived micromonospora rosaria SCSIO N160.

  2012cited by this paper
• Draft genome sequence of Streptomyces coelicoflavus ZG0656 reveals the putative biosynthetic gene cluster of acarviostatin family α‐amylase inhibitors

  2012cited by this paper
• Identification of JadG as the B ring opening oxygenase catalyzing the oxidative C-C bond cleavage reaction in jadomycin biosynthesis.

  2012cited by this paper
• Angucyclines: Biosynthesis, mode-of-action, new natural products, and synthesis.

  2012cited by this paper
• Baeyer-Villiger C-C bond cleavage reaction in gilvocarcin and jadomycin biosynthesis.

  2012cited by this paper
• Open Babel: An open chemical toolbox

  2011cited by this paper
• Overview of the CCP4 suite and current developments

  2011cited by this paper
• LigPlot+: Multiple Ligand-Protein Interaction Diagrams for Drug Discovery

  2011cited by this paper
• Cloning and Characterization of a Gene Cluster for Hatomarubigin Biosynthesis in Streptomyces sp. Strain 2238-SVT4

  2010cited by this paper
• Fluostatins produced by the heterologous expression of a TAR reassembled environmental DNA derived type II PKS gene cluster.

  2010cited by this paper
• Dali server: conservation mapping in 3D

  2010cited by this paper
• Characterization and Manipulation of the Pathway-Specific Late Regulator AlpW Reveals Streptomyces ambofaciens as a New Producer of Kinamycins

  2010cited by this paper
• Cofactor-independent oxidases and oxygenases

  2010cited by this paper
• Cloning and Characterization of the Ravidomycin and Chrysomycin Biosynthetic Gene Clusters

  2010cited by this paper
• MolProbity: all-atom structure validation for macromolecular crystallography

  2009cited by this paper
• AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading

  2009cited by this paper
• An improved general amino acid replacement matrix.

  2008cited by this paper
• Crystal Structure of the Oxygenase Component (HpaB) of the 4-Hydroxyphenylacetate 3-Monooxygenase from Thermus thermophilus HB8*

  2007cited by this paper
• Phaser crystallographic software

  2007cited by this paper
• Inference of macromolecular assemblies from crystalline state.

  2007cited by this paper
• Regiospecific chlorination of (S)-beta-tyrosyl-S-carrier protein catalyzed by SgcC3 in the biosynthesis of the enediyne antitumor antibiotic C-1027.

  2007cited by this paper
• Biosynthetic Investigations of Lactonamycin and Lactonamycin Z: Cloning of the Biosynthetic Gene Clusters and Discovery of an Unusual Starter Unit

  2007cited by this paper
• Multi-oxygenase complexes of the gilvocarcin and jadomycin biosyntheses.

  2007cited by this paper
• Ring-opening dynamics of jadomycin A and B and dalomycin T.

  2006cited by this paper
• The Oxidative Ring Cleavage in Jadomycin Biosynthesis: A Multistep Oxygenation Cascade in a Biosynthetic Black Box

  2005cited by this paper
• The dynamic structure of jadomycin B and the amino acid incorporation step of its biosynthesis.

  2004cited by this paper
• Coot: model-building tools for molecular graphics.

  2004cited by this paper
• Oxidative rearrangement processes in the biosynthesis of gilvocarcin V.

  2004cited by this paper
• Functional Angucycline-Like Antibiotic Gene Cluster in the Terminal Inverted Repeats of the Streptomyces ambofaciens Linear Chromosome

  2004cited by this paper
• The structure of ActVA‐Orf6, a novel type of monooxygenase involved in actinorhodin biosynthesis

  2003cited by this paper
• The complete gene cluster of the antitumor agent gilvocarcin V and its implication for the biosynthesis of the gilvocarcins.

  2003cited by this paper
• Macromolecular TLS refinement in REFMAC at moderate resolutions.

  2003cited by this paper
• Oxygenases without requirement for cofactors or metal ions

  2002cited by this paper
• Expression, Purification, and Characterization of AknX Anthrone Oxygenase, Which Is Involved in Aklavinone Biosynthesis in Streptomyces galilaeus

  2002cited by this paper
• Lomaiviticins A and B, potent antitumor antibiotics from Micromonospora lomaivitiensis.

  2001cited by this paper
• Cloning, Sequencing, and Heterologous Expression of the elmGHIJ Genes Involved in the Biosynthesis of the Polyketide Antibiotic Elloramycin from Streptomyces olivaceus Tü2353

  2001cited by this paper
• Cloning, sequencing, and heterologous expression of the elmGHIJ genes involved in the biosynthesis of the polyketide antibiotic elloramycin from Streptomyces olivaceus Tü2353.

  2001cited by this paper
• Correspondence e-mail:

  2000cited by this paper
• Recent changes to RasMol, recombining the variants.

  2000cited by this paper
• Fluostatins A and B, new inhibitors of dipeptidyl peptidase III, produced by Streptomyces sp. TA-3391. II. Structure determination.

  1998cited by this paper
• Cloning and heterologous expression of genes from the kinamycin biosynthetic pathway of Streptomyces murayamaensis.

  1998cited by this paper
• Refinement of macromolecular structures by the maximum-likelihood method.

  1997cited by this paper
• Processing of X-ray diffraction data collected in oscillation mode.

  1997cited by this paper
• Identification of a monooxygenase from Streptomyces coelicolor A3(2) involved in biosynthesis of actinorhodin: purification and characterization of the recombinant enzyme

  1997cited by this paper
• [20] Processing of X-ray diffraction data collected in oscillation mode.

  1997cited by this paper
• Biosynthesis of the Kinamycins.

  1997cited by this paper
• Accumulation of the angucycline antibiotic rabelomycin after disruption of an oxygenase gene in the jadomycin B biosynthetic gene cluster of Streptomyces venezuelae.

  1996cited by this paper
• Cloning and characterization of polyketide synthase genes for jadomycin B biosynthesis in Streptomyces venezuelae ISP5230.

  1994cited by this paper
• The CCP4 suite: programs for protein crystallography.

  1994cited by this paper
• Conditions for the production of jadomycin B byStreptomyces venezuelae ISP5230: Effects of heat shock, ethanol treatment and phage infection

  1994cited by this paper
• Alpha plus beta folds revisited: some favoured motifs.

  1993cited by this paper
• Tetracenomycin F1 monooxygenase: oxidation of a naphthacenone to a naphthacenequinone in the biosynthesis of tetracenomycin C in Streptomyces glaucescens.

  1993cited by this paper
• Structures and biological properties of Kinamycin A, B, C, and D.

  1973cited by this paper
• Structures and Biological Properties of Kinamycin A, B, C, and D

  1973cited by this paper
• Electronic Reprint Biological Crystallography Phenix : a Comprehensive Python-based System for Macromolecular Structure Solution

  year unknowncited by this paper

• Functional Conservation and Divergence of AlpJ-Family Oxygenases Catalyzing C-C Bond Cleavage in Atypical Angucycline Biosynthesis.

  2025cites this paper
• Structural Insights into 4,5-DOPA Extradiol Dioxygenase from Beta vulgaris: Unraveling the Key Step in Versatile Betalain Biosynthesis

  2025cites this paper
• The oxidative rearrangements in bacterial aromatic polyketide biosynthesis.

  2025cites this paper
• Role of a FAD-dependent monooxygenase in diazo group functionalization of kinamycin in Streptomyces ambofaciens

  2024cites this paper
• Unraveling proton-coupled electron transfer in cofactor-free oxidase- and oxygenase-catalyzed oxygen activation: a theoretical view.

  2024cites this paper
• Biosynthesis of Atypical Angucyclines Unveils New Ring Rearrangement Reactions Catalyzed by Flavoprotein Monooxygenases.

  2024cites this paper
• The Chemistry of Angucyclines.

  2024cites this paper
• Cofactor-independent C–C bond cleavage reactions catalyzed by the AlpJ family of oxygenases in atypical angucycline biosynthesis

  2024cites this paper
• Sorbremnoids A and B: NLRP3 Inflammasome Inhibitors Discovered from Spatially Restricted Crosstalk of Biosynthetic Pathways.

  2024cites this paper
• Multienzyme Cascade Catalyzed Skeleton Rearrangement in a Caged Polyketide Biosynthesis.

  2024cites this paper
• Marine actinomycetes-derived angucyclines and angucyclinones with biosynthesis and activity--past 10 years (2014-2023).

  2024cites this paper
• Total Biosynthesis of Mutaxanthene Unveils a Flavoprotein Monooxygenase Catalyzing Xanthene Ring Formation.

  2023cites this paper
• Biosynthesis of AS2077715 and Funiculosin: Pathway Reconstitution and Identification of Enzymes that Form the All-cis Cyclopentanetetraol Moiety.

  2023cites this paper
• Molecular mechanism of GylR-mediated regulation of glycerol metabolism in Streptomyces clavuligerus NRRL 3585

  2022cites this paper
• Biochemical and structural insights of multifunctional flavin-dependent monooxygenase FlsO1-catalyzed unexpected xanthone formation

  2022cites this paper
• Disclosing biosynthetic connections and functions of atypical angucyclinones with a fragmented C-ring.

  2021cites this paper
• Genome mining of novel rubiginones from Streptomyces sp. CB02414 and characterization of the post-PKS modification steps in rubiginone biosynthesis

  2021cites this paper
• Himalaquinones A-G, Angucyclinone-Derived Metabolites Produced by the Himalayan Isolate Streptomyces sp. PU-MM59.

  2021cites this paper
• Catalysis and evolution of the ring-opening oxygenases in biosynthesis of atypical angucyclines

  2019cites this paper
• Bacterial Type II Polyketide Synthases

  2019cites this paper
• [Baeyer-Villiger monooxygenases in the biosynthesis of microbial secondary metabolites].

  2019influential citation
• Reconstitution of Kinamycin Biosynthesis within the Heterologous Host Streptomyces albus J1074.

  2018cites this paper
• The functional differentiation of the post-PKS tailoring oxygenases contributed to the chemical diversities of atypical angucyclines

  2018cites this paper
• Molecular basis of dimer formation during the biosynthesis of benzofluorene-containing atypical angucyclines

  2018cites this paper
• Isolation, structure elucidation and biosynthesis of benzo[b]fluorene nenestatin A from deep-sea derived Micromonospora echinospora SCSIO 04089

  2017cites this paper
• New insights into bacterial type II polyketide biosynthesis

  2017cites this paper