Metabolism of ipecac alkaloids cephaeline and emetine by human hepatic microsomal cytochrome P450s, and their inhibitory effects on P450 enzyme activities.

No abstract is available for this paper.

• Publication year

  2001

• Venue

  Biological and Pharmaceutical Bulletin

• Publication date

  2001-06-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1248/BPB.24.678PMID 11411558
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Phenytoin as a Possible Cause of Acetaminophen Hepatotoxicity: Case Report and Review of the Literature

  2000cited by this paper
• Ipecac alkaloids from Cephaelis acuminata.

  1999cited by this paper
• Roles of CYP2A6 and CYP2B6 in nicotine C-oxidation by human liver microsomes

  1999cited by this paper
• Identification of human cytochrome P450 isoforms involved in the metabolism of brotizolam.

  1997cited by this paper
• Selective Serotonin Reuptake Inhibitors and CNS Drug Interactions

  1997cited by this paper
• Vomiting induction by ipecac syrup in dogs and ferrets.

  1997cited by this paper
• Involvement of CYP3A4 and CYP2D6 in the Metabolism of Haloperidol

  1997cited by this paper
• Theophylline metabolism in human liver microsomes: inhibition studies.

  1996cited by this paper
• Triazolam biotransformation by human liver microsomes in vitro: effects of metabolic inhibitors and clinical confirmation of a predicted interaction with ketoconazole.

  1996cited by this paper
• In Vitro Prediction of the Terfenadine‐Ketoconazole Pharmacokinetic Interaction

  1994cited by this paper
• Measurement of steroid hydroxylation reactions by high-performance liquid chromatography as indicator of P450 identity and function.

  1991cited by this paper
• Residual Gastric Content after Gastric Lavage and Ipecacuanha-Induced Emesis in Self-Poisoned Patients: An Endoscopic Study

  1991cited by this paper
• Tolbutamide and mephenytoin hydroxylation by human cytochrome P450s in the CYP2C subfamily.

  1990cited by this paper
• High-performance liquid chromatographic assays for bufuralol 1'-hydroxylase, debrisoquine 4-hydroxylase, and dextromethorphan O-demethylase in microsomes and purified cytochrome P-450 isozymes of human liver.

  1987cited by this paper
• Quinolizidines. XI. Structure determination of the Alangium alkaloid desmethylpsychotrine through synthetic incorporation of ethyl cincholoiponate into (+)-9-demethylpsychotrine

  1985cited by this paper
• Quinolizidines. XVI. Chiral Syntheses of 9-Demethylcephaeline and 10-Demethylcephaeline

  1985cited by this paper
• Quinolizidines. XII. Synthetic Incorporation of Ethyl Cincholoiponate into a Tricyclic Intermediate Adaptable to Chiral Syntheses of the 10-Hydroxy-9-methoxybenzo [a] quinolizidine-Type Alangium Alkaloids

  1985cited by this paper
• Mephenytoin hydroxylation polymorphism: Characterization of the enzymatic deficiency in liver microsomes of poor metabolizers phenotyped in vivo

  1985cited by this paper

• Emetine: Advances in Pharmacology, Toxicology, and Chromatographic Approaches.

  2025cites this paper
• Construction of refined CYP2D6-Template system for studies of its metabolism and inhibition.

  2025cites this paper
• Analyzing the metabolic fate of oral administration drugs: A review and state-of-the-art roadmap

  2022cites this paper
• A Paradoxically Significant Medicinal Plant Carapichea ipecacuanha: A Review

  2020cites this paper
• Reviewing the mechanisms of natural product-drug interactions involving efflux transporters and metabolic enzymes.

  2019cites this paper
• Role of plant alkaloids on human health: A review of biological activities

  2018cites this paper
• Herb-Drug Pharmacokinetic Interactions: Transport and Metabolism of Indinavir in the Presence of Selected Herbal Products

  2015cites this paper
• Potential inhibitory effect of herbal medicines on rat hepatic cytochrome P450 2D gene expression and metabolic activity.

  2014cites this paper
• Impact of selected herbal products on intestinal epithelial permeation and metabolism of indinavir

  2014influential citation
• Diuretics, Ipecac, and Laxatives

  2012cites this paper
• HPLC (High Performance Liquid Chromatography) quantitative method for cephaeline hydrochloride and ipecine hydrochloride in ipecacuanha medicinal material and preparation of ipecacuanha medicinal material

  2012cites this paper
• Disposition pathways and pharmacokinetics of herbal medicines in humans.

  2012cites this paper
• Evaluation of pharmacological properties of Danshen compounds by computational and biochemical approaches

  2012cites this paper
• Pharmacophore, QSAR, and binding mode studies of substrates of human cytochrome P450 2D6 (CYP2D6) using molecular docking and virtual mutations and an application to chinese herbal medicine screening.

  2012cites this paper
• Predicting oxidation sites with order of occurrence among multiple sites for CYP4A-mediated reactions.

  2011cites this paper
• ADME properties of herbal medicines in humans: evidence, challenges and strategies.

  2011cites this paper
• Biochemistry and Occurrence of O-Demethylation in Plant Metabolism

  2010cites this paper
• Classification of Cytochrome P450 Inhibitors with Respect to Binding Free Energy and pIC50 Using Common Molecular Descriptors

  2009cites this paper
• New insights into the structural characteristics and functional relevance of the human cytochrome P450 2D6 enzyme

  2009cites this paper
• Substrate specificity, inhibitors and regulation of human cytochrome P450 2D6 and implications in drug development.

  2009cites this paper
• Molecular modes of action of cytotoxic alkaloids: from DNA intercalation, spindle poisoning, topoisomerase inhibition to apoptosis and multiple drug resistance.

  2007cites this paper
• Emetine and/or its Metabolites are Genotoxic in Somatic Cells of Drosophila Melanogaster

  2007cites this paper
• Interactions of Herbs with Cytochrome P450

  2003cites this paper
• Use of Robust Classification Techniques for the Prediction of Human Cytochrome P450 2D6 Inhibition

  2003cites this paper
• Urinary excretion of ipecac alkaloids in human volunteers.

  2002cites this paper