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Formulation, In-vitro and In-vivo Evaluation of Enteric Coated Pellets of Substituted Benzimidazole Proton Pump Inhibitor

K. Bahmani,D. Bhatt,Yashpaul Singla

Published 2018 in Unknown venue

ABSTRACT

The objective of present work was to design, formulate and characterize the enteric coated pellets of Rabeprazole using dry powder layering method and also study the ulcer protecting effect of pellets against the gastric lesions induced by 70 % ethanol in albino wistar rats. The evaluation of pellets was done using DSC, FT-IR and SEM study. The kinetic release study was also done on all formulations. In vitro drug release study data was fitted on the different kinetic models and formulation F5 showed the Higuchi drug release. In vivo antiulcer activity was done on formulation F5 showed that the formulation was able to protect the rat stomach against ulcers formation. The levels of thiobarbituric acid, estimation of lipid peroxidation, estimation of reduced glutathione, estimation of catalase activity and protein determination was also done. -------------------------------------------------------------------------------------------------------------------------------------Date of Submission: 20-07-2018 Date of acceptance: 04-08-2018 -------------------------------------------------------------------------------------------------------------------------------------

PUBLICATION RECORD

  • Publication year

    2018

  • Venue

    Unknown venue

  • Publication date

    Unknown publication date

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  • External record

    Open on Semantic Scholar

  • Source metadata

    Semantic Scholar

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