Tying Metabolic Branches With Histone Tails Using Systems Biology

Histone modifications represent an innate cellular mechanism to link nutritional status to gene expression. Metabolites such as acetyl-CoA and S-adenosyl methionine influence gene expression by serving as substrates for modification of histones. Yet, we lack a predictive model for determining histone modification levels based on cellular metabolic state. The numerous metabolic pathways that intersect with histone marks makes it highly challenging to understand their interdependencies. Here, we highlight new systems biology tools to unravel the impact of nutritional cues and metabolic fluxes on histone modifications.

• Publication year

  2019

• Venue

  Epigenetics Insights

• Publication date

  2019-01-01

• Fields of study

  Biology, Medicine, Computer Science

• Identifiers
  DOI 10.1177/2516865719869683PMID 31448363PMCID 6689906
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Genome-scale network model of metabolism and histone acetylation reveals metabolic dependencies of histone deacetylase inhibitors

  2019cited by this paper
• Comprehensive Mapping of Pluripotent Stem Cell Metabolism Using Dynamic Genome-Scale Network Modeling.

  2017influential reference
• The impact of cellular metabolism on chromatin dynamics and epigenetics

  2017cited by this paper
• Histone Deacetylase Inhibitors as Anticancer Drugs

  2017cited by this paper
• Metabolic control of methylation and acetylation.

  2016cited by this paper
• Integrated metabolic modelling reveals cell-type specific epigenetic control points of the macrophage metabolic network

  2015cited by this paper
• Using Genome-scale Models to Predict Biological Capabilities.

  2015cited by this paper
• Computational Analysis of Reciprocal Association of Metabolism and Epigenetics in the Budding Yeast: A Genome-Scale Metabolic Model (GSMM) Approach

  2014cited by this paper
• Glutamine-driven oxidative phosphorylation is a major ATP source in transformed mammalian cells in both normoxia and hypoxia

  2013cited by this paper
• Influence of metabolism on epigenetics and disease.

  2013cited by this paper
• A quantitative atlas of histone modification signatures from human cancer cells

  2013cited by this paper
• A tale of metabolites: the cross-talk between chromatin and energy metabolism.

  2013cited by this paper
• A two-way street: reciprocal regulation of metabolism and signalling

  2012cited by this paper
• Network-based prediction of human tissue-specific metabolism

  2008cited by this paper
• Global reconstruction of the human metabolic network based on genomic and bibliomic data

  2007cited by this paper
• Histone deacetylase inhibitors.

  2005cited by this paper

• Genome-wide mapping of main histone modifications and coordination regulation of metabolic genes under salt stress in pea (Pisum sativum L)

  2024cites this paper
• Next-Generation Genome-Scale Metabolic Modeling through Integration of Regulatory Mechanisms

  2021cites this paper