White Matter Microstructural Change Contributes to Worse Cognitive Function in Patients With Type 2 Diabetes

Patients with type 2 diabetes mellitus (T2DM) have a considerably high risk of developing dementia, especially for those with mild cognitive impairment (MCI). The investigation of the microstructural change of white matter (WM) between T2DM with amnesic MCI (T2DM-aMCI) and T2DM with normal cognition (T2DM-NC) and their relationships to cognitive performances can help to understand the brain variations in T2DM-related amnesic cognitive impairment. In the current study, 36 T2DM-aMCI patients, 40 T2DM-NC patients, and 40 healthy control (HC) individuals underwent diffusion tensor image and T1-weighted MRI scans and comprehensive cognition assessments. All of these cognitive functions exhibited intergroup ranking differences in patients. The T2DM-NC patients and HC individuals did not reveal any significant differences in WM integrity. The T2DM-aMCI patients showed disrupted integrity in multiple WM tracts compared with HC and T2DM-NC. Specifically, the damaged WM integrity of the right inferior fronto-occipital fasciculus and the right inferior longitudinal fasciculus exhibited significant correlations with episodic memory and attention function impairment in T2DM patients. Furthermore, cognitive impairment-related WM microstructural damage was associated with the degeneration of cortex connected to the affected WM tract. These findings indicate that degeneration exists extensively in WM tracts in T2DM-aMCI, whereas no brain WM damage is evident in T2DM-NC.

• Publication year

  2019

• Venue

  Diabetes

• Publication date

  2019-08-22

• Fields of study

  Medicine

• Identifiers
  DOI 10.2337/db19-0233PMID 31439643PMCID 6804632
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Alzheimer's Disease and Type 2 Diabetes: A Critical Assessment of the Shared Pathological Traits

  2018cited by this paper
• Cortical thickness contributes to cognitive heterogeneity in patients with type 2 diabetes mellitus

  2018cited by this paper
• An investigation of white matter integrity and attention deficits following traumatic brain injury

  2018cited by this paper
• Default Mode Network Connectivity and Related White Matter Disruption in Type 2 Diabetes Mellitus Patients Concurrent with Amnestic Mild Cognitive Impairment.

  2017cited by this paper
• The Effects of an APOE Promoter Polymorphism on Human White Matter Connectivity during Non-Demented Aging

  2016cited by this paper
• Micro-structural white matter abnormalities in type 2 diabetic patients: a DTI study using TBSS analysis

  2016cited by this paper
• A Diffusion Tensor Imaging Study on White Matter Abnormalities in Patients with Type 2 Diabetes Using Tract-Based Spatial Statistics

  2016cited by this paper
• Type 2 diabetes mellitus is associated with brain atrophy and hypometabolism in the ADNI cohort

  2016cited by this paper
• Cognitive function in patients with diabetes mellitus: guidance for daily care.

  2015cited by this paper
• Conversion of Mild Cognitive Impairment to Dementia among Subjects with Diabetes: A Population-Based Study of Incidence and Risk Factors with Five Years of Follow-up

  2014cited by this paper
• Cerebral White Matter Integrity and Resting-State Functional Connectivity in Middle-aged Patients With Type 2 Diabetes

  2014cited by this paper
• The anatomy of fronto-occipital connections from early blunt dissections to contemporary tractography.

  2014cited by this paper
• Type 2 diabetes as a risk factor for cognitive impairment: current insights

  2014cited by this paper
• Intralobar fibres of the occipital lobe: a post mortem dissection study.

  2014cited by this paper
• Early Frontal Structural and Functional Changes in Mild White Matter Lesions Relevant to Cognitive Decline

  2014cited by this paper
• White Matter Integrity Disruptions Associated With Cognitive Impairments in Type 2 Diabetic Patients

  2014influential reference
• Regional Neuronal Network Failure and Cognition in Late-Onset Sporadic Alzheimer Disease

  2014cited by this paper
• Prediction of Alzheimer disease in subjects with amnestic and nonamnestic MCI

  2013cited by this paper
• White matter correlates of cognitive domains in normal aging with diffusion tensor imaging

  2013cited by this paper
• Different Patterns of White Matter Disruption among Amnestic Mild Cognitive Impairment Subtypes: Relationship with Neuropsychological Performance

  2013cited by this paper
• Type 2 Diabetes and Cognitive Impairment: Linking Mechanisms

  2012cited by this paper
• Microstructural White Matter Abnormalities and Cognitive Functioning in Type 2 Diabetes

  2012cited by this paper
• Diabetes and cognitive dysfunction.

  2012cited by this paper
• Episodic memory function is associated with multiple measures of white matter integrity in cognitive aging

  2011cited by this paper
• Pathophysiology of cognitive dysfunction in older people with type 2 diabetes: vascular changes or neurodegeneration?

  2010cited by this paper
• Mapping anatomical connectivity patterns of human cerebral cortex using in vivo diffusion tensor imaging tractography.

  2009cited by this paper
• Stereotaxic white matter atlas based on diffusion tensor imaging in an ICBM template

  2008cited by this paper
• Relation of diabetes to mild cognitive impairment.

  2007cited by this paper
• Toward accurate diagnosis of white matter pathology using diffusion tensor imaging

  2007cited by this paper
• White matter integrity and cognition in chronic traumatic brain injury: a diffusion tensor imaging study.

  2007cited by this paper
• Anatomically related grey and white matter abnormalities in adolescent-onset schizophrenia.

  2007cited by this paper
• Boston Naming Test in Chinese Elderly, Patient with Mild Cognitive Impairment and Alzheimer's Dementia

  2006cited by this paper
• Tract-based spatial statistics: Voxelwise analysis of multi-subject diffusion data

  2006cited by this paper
• MR imaging of the temporal stem: anatomic dissection tractography of the uncinate fasciculus, inferior occipitofrontal fasciculus, and Meyer's loop of the optic radiation.

  2004cited by this paper
• Fiber tract-based atlas of human white matter anatomy.

  2004cited by this paper
• Advances in functional and structural MR image analysis and implementation as FSL.

  2004influential reference
• Insulin-Degrading Enzyme as a Downstream Target of Insulin Receptor Signaling Cascade: Implications for Alzheimer's Disease Intervention

  2004cited by this paper
• Mild cognitive impairment as a diagnostic entity

  2004influential reference
• Mechanisms of Memory

  2003cited by this paper
• Insulin Receptor Substrate-2 Deficiency Impairs Brain Growth and Promotes Tau Phosphorylation

  2003cited by this paper
• Microstructural and physiological features of tissues elucidated by quantitative-diffusion-tensor MRI.

  1996cited by this paper
• MR diffusion tensor spectroscopy and imaging.

  1994cited by this paper
• Quantitative and qualitative analyses of clock drawings in Alzheimer's and Huntington's disease.

  1992cited by this paper
• Sex differences on the Wechsler Adult Intelligence Scale—Revised for China.

  1991cited by this paper
• The prevalence of dementia and Alzheimer's disease in Shanghai, China: Impact of age, gender, and education

  1990influential reference
• Mechanisms of memory.

  1986cited by this paper
• The Trail Making Test in neuropsychological diagnosis.

  1972influential reference
• Lexamen psychologique : Dans les cas d'encephalopathie traumatique (Les problemes)

  1941cited by this paper
• For Personal Use. Only Reproduce with Permission the Lancet Publishing Group. Insulin and the Brain Insulin and Neurodegenerative Disease Insulin and Neurodegenerative Disease: Shared and Specific Mechanisms

  year unknowncited by this paper

• Transcriptomic insights into the antidiabetic effects of mulberry leaf Fu brick tea in GK rats

  2026cites this paper
• Amide proton transfer imaging reveals cerebral metabolic alterations associated with cognitive impairment in type 2 diabetes mellitus

  2025cites this paper
• A discussion on the application of fluorescence micro-optical sectioning tomography in the research of cognitive dysfunction in diabetes

  2025cites this paper
• The association between long-term trajectories of insulin resistance and brain structural integrity in middle-aged and older adults

  2025cites this paper
• Cerebrovascular health impacts processing speed through anterior white matter alterations: a UK biobank study

  2025cites this paper
• Altered White Matter Microstructure and Cerebral Spontaneous Activity in Early Neurosyphilis Without Human Immunodeficiency Virus Infection.

  2025cites this paper
• H4K12 lactylation potentiates mitochondrial oxidative stress via the Foxo1 pathway in diabetes-induced cognitive impairment

  2025cites this paper
• H3K18 lactylation potentiates microglial polarization via the TLR4 pathway in diabetes-induced cognitive impairment

  2025cites this paper
• Vinegar-processed Schisandra chinensis polysaccharide ameliorates type 2 diabetes via modulation serum metabolic profiles, gut microbiota, and fecal SCFAs.

  2025cites this paper
• Cerebrovascular health mediates processing speed change through anterior white matter alterations: A UK Biobank Study

  2024cites this paper
• AD-Like Neuropsychiatric Dysfunction in a Mice Model Induced by a Combination of High-Fat Diet and Intraperitoneal Injection of Streptozotocin

  2024cites this paper
• Identification of the Shared Gene Signatures Between Alzheimer’s Disease and Diabetes-Associated Cognitive Dysfunction by Bioinformatics Analysis Combined with Biological Experiment

  2024cites this paper
• The impact of gut microbial dysbiosis on the atrophy of the hippocampus and abnormal metabolism of N-acetyl aspartate in type 2 diabetic rats

  2024cites this paper
• Cerebellar gray matter and white matter damage among older adults with prediabetes.

  2024cites this paper
• Protective effect of melatonin against metabolic disorders and neuropsychiatric injuries in type 2 diabetes mellitus mice.

  2024cites this paper
• Berberine improves cognitive impairment by alleviating brain atrophy and promoting white matter reorganization in diabetic db/db mice: a magnetic resonance imaging-based study

  2024influential citation
• White matter microstructure alterations in type 2 diabetes mellitus and its correlation with cerebral small vessel disease and cognitive performance

  2024cites this paper
• Characterization of diffusion magnetic resonance imaging revealing relationships between white matter disconnection and behavioral disturbances in mild cognitive impairment: a systematic review

  2023cites this paper
• Altered Functional Connectivity Density in Type 2 Diabetes Mellitus with and without Mild Cognitive Impairment

  2023cites this paper
• Altered dynamic functional architecture in type 2 diabetes mellitus

  2023cites this paper
• Disrupted structural connectivity and less efficient network system in patients with the treatment-naive adult attention-deficit/hyperactivity disorder

  2023cites this paper
• Long-term changes in cognitive status of patients with type 2 diabetes mellitus after coronary artery bypass graft surgery

  2023cites this paper
• Magnetic resonance imaging detects cerebral gray and white matter injury correlated with cognitive impairments in diabetic db/db mice.

  2023cites this paper
• Diabetes status and cognitive function in middle-aged and older adults in the Canadian longitudinal study on aging

  2023cites this paper
• ECHDC3 variant regulates the right hippocampal microstructural integrity and verbal memory in type 2 diabetes mellitus.

  2023cites this paper
• Neuron-targeted overexpression of caveolin-1 alleviates diabetes-associated cognitive dysfunction via regulating mitochondrial fission-mitophagy axis

  2023cites this paper
• Altered local gyrification and functional connectivity in type 2 diabetes mellitus patients with mild cognitive impairment: A pilot cross-sectional small-scale single center study

  2022cites this paper
• Altered functional hubs and connectivity in type 2 diabetes mellitus with and without mild cognitive impairment

  2022cites this paper
• Gray and white matter abnormality in patients with T2DM-related cognitive dysfunction: a systemic review and meta-analysis

  2022cites this paper
• Impaired recollection and initially preserved familiarity in a patient with bilateral fornix transection following third ventricle colloid cyst removal: A two-year follow-up study

  2022cites this paper
• White matter microstructural integrity and BOLD fluctuation alterations mediated the effects of insulin resistance on cognitive function in patients with type 2 diabetes mellitus

  2022cites this paper
• Tractography in Type 2 Diabetes Mellitus With Subjective Memory Complaints: A Diffusion Tensor Imaging Study

  2022cites this paper
• Type 2 Diabetes Mellitus-associated Cognitive Dysfunction: Advances in Potential Mechanisms and Therapies.

  2022cites this paper
• Caveolin-1 Alleviates Diabetes-Associated Cognitive Dysfunction Through Modulating Neuronal Ferroptosis-Mediated Mitochondrial Homeostasis

  2022cites this paper
• Early prevention of cognitive impairment in the community population: The Beijing Aging Brain Rejuvenation Initiative

  2021cites this paper
• Chinese Color Nest Project : An accelerated longitudinal brain-mind cohort

  2021cites this paper
• Altered Gray Matter Volume, Functional Connectivity, and Degree Centrality in Early-Onset Type 2 Diabetes Mellitus

  2021cites this paper
• Abnormalities of Brain White Matter in Type 2 Diabetes Mellitus: A Meta-Analysis of Diffusion Tensor Imaging

  2021cites this paper
• The relationship between diabetes-related cognitive dysfunction and leukoaraiosis

  2021cites this paper
• Structural and Functional Changes Are Related to Cognitive Status in Wilson’s Disease

  2021cites this paper
• Relationship Between Type 2 Diabetes and White Matter Hyperintensity: A Systematic Review

  2020cites this paper
• Effects of Nigella sativa seed polysaccharides on type 2 diabetic mice and gut microbiota.

  2020cites this paper