Knockdown of JNK rescues 3T3-L1 adipocytes from insulin resistance induced by mitochondrial dysfunction.

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Biochemical and Biophysical Research Communications - BBRC

• Publication date

  2009-01-23

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.bbrc.2008.11.121PMID 19063863
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Mitochondrial energetics and insulin resistance.

  2008cited by this paper
• Family History of Diabetes Links Impaired Substrate Switching and Reduced Mitochondrial Content in Skeletal Muscle

  2007cited by this paper
• Impaired in vivo mitochondrial function but similar intramyocellular lipid content in patients with type 2 diabetes mellitus and BMI-matched control subjects

  2006cited by this paper
• Etiology of insulin resistance.

  2006cited by this paper
• Skeletal Muscle Mitochondrial Functions, Mitochondrial DNA Copy Numbers, and Gene Transcript Profiles in Type 2 Diabetic and Nondiabetic Subjects at Equal Levels of Low or High Insulin and Euglycemia

  2006cited by this paper
• Functional in vivo interactions between JNK1 and JNK2 isoforms in obesity and insulin resistance.

  2006cited by this paper
• Molecular Mechanisms of Insulin Resistance in Humans and Their Potential Links With Mitochondrial Dysfunction

  2006cited by this paper
• Exercise training and calorie restriction increase SREBP-1 expression and intramuscular triglyceride in skeletal muscle.

  2006cited by this paper
• JNK1 deficiency does not enhance muscle glucose metabolism in lean mice.

  2006cited by this paper
• Insulin-induced stimulation of JNK and the PI 3-kinase/mTOR pathway leads to phosphorylation of serine 318 of IRS-1 in C2C12 myotubes.

  2005cited by this paper
• JNK and Tumor Necrosis Factor-α Mediate Free Fatty Acid-induced Insulin Resistance in 3T3-L1 Adipocytes*

  2005cited by this paper
• Oxidative stress and the JNK pathway in diabetes.

  2005cited by this paper
• Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents.

  2005cited by this paper
• Roles of mTOR and JNK in serine phosphorylation, translocation, and degradation of IRS-1.

  2005cited by this paper
• Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes.

  2004cited by this paper
• Mitochondrial Dysfunction in the Elderly: Possible Role in Insulin Resistance

  2003cited by this paper
• Effect of insulin on human skeletal muscle mitochondrial ATP production, protein synthesis, and mRNA transcripts

  2003cited by this paper
• Targeting JNK for therapeutic benefit: from junk to gold?

  2003cited by this paper
• Mechanism by Which Fatty Acids Inhibit Insulin Activation of Insulin Receptor Substrate-1 (IRS-1)-associated Phosphatidylinositol 3-Kinase Activity in Muscle*

  2002cited by this paper
• Lipid-Induced Insulin Resistance in Human Muscle Is Associated With Changes in Diacylglycerol, Protein Kinase C, and IκB-α

  2002cited by this paper
• A central role for JNK in obesity and insulin resistance

  2002cited by this paper
• Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha.

  2002cited by this paper
• Skeletal muscle lipid content and insulin resistance: evidence for a paradox in endurance-trained athletes.

  2001cited by this paper
• Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade.

  1999cited by this paper
• Bcl-2 protects against FCCP-induced apoptosis and mitochondrial membrane potential depolarization in PC12 cells.

  1999cited by this paper
• Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: a 1H NMR spectroscopy study

  1999cited by this paper
• Intramyocellular triglyceride content is a determinant of in vivo insulin resistance in humans: a 1H-13C nuclear magnetic resonance spectroscopy assessment in offspring of type 2 diabetic parents.

  1999cited by this paper
• Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity.

  1999cited by this paper
• Subcutaneous Abdominal Fat and Thigh Muscle Composition Predict Insulin Sensitivity Independently of Visceral Fat

  1997cited by this paper
• Skeletal Muscle Triglyceride Levels Are Inversely Related to Insulin Action

  1997cited by this paper
• Mechanisms of fatty acid-induced inhibition of glucose uptake.

  1994cited by this paper
• Skeletal muscle substrate utilization during submaximal exercise in man: effect of endurance training.

  1993cited by this paper
• Mechanisms by which mitochondria transport calcium.

  1990cited by this paper

• Pathogenetic Pathways in Nonalcoholic Fatty Liver Disease: An Incomplete Jigsaw Puzzle.

  2023cites this paper
• Tumor necrosis factor-α promotes lipolysis and reduces insulin sensitivity by activating nuclear factor kappa B and c-Jun N-terminal kinase in primary bovine adipocytes.

  2022cites this paper
• JNK signaling pathway in metabolic disorders: An emerging therapeutic target.

  2021cites this paper
• Role of c-Jun N-terminal Kinase (JNK) in Obesity and Type 2 Diabetes

  2020cites this paper
• Rapamycin negatively impacts insulin signaling, glucose uptake and uncoupling protein-1 in brown adipocytes.

  2016cites this paper
• A Small Molecule that Induces Intrinsic Pathway Apoptosis with Unparalleled Speed.

  2015cites this paper
• Knockdown of LYRM1 Rescues Insulin Resistance and Mitochondrial Dysfunction Induced by FCCP in 3T3-L1 Adipocytes

  2014cites this paper
• Hyperglycemia in Critical Illness

  2013cites this paper
• Knockdown of NYGGF4 (PID1) rescues insulin resistance and mitochondrial dysfunction induced by FCCP in 3T3-L1 adipocytes.

  2012cites this paper
• JNK Inhibition by SP600125 Attenuates trans-10, cis-12 Conjugated Linoleic Acid-Mediated Regulation of Inflammatory and Lipogenic Gene Expression

  2011cites this paper
• cJun NH2-terminal kinase 1 (JNK1): roles in metabolic regulation of insulin resistance.

  2010cites this paper
• The Role of JNK Proteins in Metabolism

  2010cites this paper
• Current world literature.

  2010cites this paper
• Mitochondrial development and the influence of its dysfunction during rat adipocyte differentiation

  2010cites this paper
• Hyperglycemia in Critical Illness: A Review

  2009cites this paper