Effects of LY274614, a competitive NMDA receptor antagonist, on the micturition reflex in the urethane‐anaesthetized rat

No abstract is available for this paper.

• Publication year

  1993

• Venue

  British Journal of Pharmacology

• Publication date

  1993-09-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1111/j.1476-5381.1993.tb13774.xPMID 8106110PMCID PMC2175996
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  1980cited by this paper
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  1960cited by this paper
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