The investigation of the interaction of Armodafinil with membrane lipids by using DPPC model membrane system

ÖZET Amaç: Modafinilin rasemik bileşiğinin R-enantiyomeri olan Armodafinil (ARM) tam olarak bilinmeyen hücresel etki mekanizması ile uyku bozukluklarında kullanılan merkezi sinir sistemi (MSS) uyarıcı ve uyanıklığı arttırıcı bir ajandır. Her ne kadar ARM’nin uyku/uyanıklık düzenini etkileyen enzimlere ve reseptörlere bağlanmadığı ve vücutta çok iyi dağıldığı gösterilse de, bildiğimiz kadarıyla onun MSS’deki etkinliğini değerlendiren bir çalışma bulunmamaktadır. Bir ilacın lipid çözünürlüğünün onun MSS erişilebilirliğini direkt olarak etkilediği göz önünde bulundurulduğunda ARM’nin lipidlerin içine nasıl nüfuz ettiği ve onlarla ne tarz etkileşmelere girdiğinin araştırılması bu konuya faydalı katkılar sağlayabilir. Bu bağlamda, bu çalışmada dipalmitoilfosfatidilkolin (DPPC) multilamellar veziküler (MLVs) adlı basitleştirilmiş model membran sistemi ile ARM’in konsantrasyona bağlı etkileşmeleri araştırıldı.

• Publication year

  2019

• Venue

  Turkish Bulletin of Hygiene and Experimental Biology

• Publication date

  Unknown publication date

• Fields of study

  Not labeled

• Identifiers
  DOI 10.5505/turkhijyen.2018.68094
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

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