Expressional and Mutational Analysis of Pro-apoptotic Bcl-2 Member PUMA in Hepatocellular Carcinomas

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Digestive Diseases and Sciences

• Publication date

  2008-05-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/s10620-007-9987-xPMID 17934815
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Loss of the tissue-specific proapoptotic BH3-only protein Nbk/Bik is a unifying feature of renal cell carcinoma

  2006cited by this paper
• Caspase-8 gene is frequently inactivated by the frameshift somatic mutation 1225_1226delTG in hepatocellular carcinomas

  2005cited by this paper
• CASPASE-8 gene is inactivated by somatic mutations in gastric carcinomas.

  2005cited by this paper
• Molecular mechanisms in hepatocellular carcinoma development.

  2005cited by this paper
• Inactivating mutation of the pro‐apoptotic gene BID in gastric cancer

  2004influential reference
• Inactivating mutations of proapoptotic Bad gene in human colon cancers.

  2004cited by this paper
• Somatic mutations of CASP3 gene in human cancers

  2004cited by this paper
• Mutational analysis of Noxa gene in human cancers

  2003cited by this paper
• Puma is an essential mediator of p53-dependent and -independent apoptotic pathways.

  2003cited by this paper
• Mutations of the BIK gene in human peripheral B‐cell lymphomas

  2003cited by this paper
• PUMA in head and neck cancer.

  2003cited by this paper
• Stomach cancer highly expresses both initiator and effector caspases; an immunohistochemical study

  2002cited by this paper
• PUMA induces the rapid apoptosis of colorectal cancer cells.

  2001cited by this paper
• Caspase 7 downregulation as an immunohistochemical marker of colonic carcinoma.

  2001cited by this paper
• Expression of Fas and Fas-related molecules in human hepatocellular carcinoma.

  2001influential reference
• Mutations of the bak gene in human gastric and colorectal cancers.

  2000cited by this paper
• Mechanisms of apoptosis.

  2000cited by this paper
• Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis.

  2000cited by this paper
• Alterations of Fas (Apo-1/CD95) gene in non-small cell lung cancer

  1999cited by this paper
• Immunohistochemical localization of FAP‐1, an inhibitor of Fas‐mediated apoptosis, in normal and neoplastic human tissues

  1999cited by this paper
• Alterations of Fas (Apo-1/CD95) gene in cutaneous malignant melanoma.

  1999cited by this paper
• Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors.

  1998cited by this paper
• HETERODIMERIZATION WITH ANTI-APOPTOSIS PROTEINS IS INSUFFICIENT FOR INDUCTION OF CELL DEATH*

  1997cited by this paper
• Functional Dissection of the Pro-apoptotic Protein Bik

  1997cited by this paper
• Somatic Frameshift Mutations in the BAX Gene in Colon Cancers of the Microsatellite Mutator Phenotype

  1997cited by this paper
• Apoptosis by death factor.

  1997cited by this paper
• Interactions between p53 and MDM2 in a mammalian cell cycle checkpoint pathway.

  1994cited by this paper
• A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia.

  1992cited by this paper
• Primary carcinoma of the liver. A study of 100 cases among 48,900 necropsies

  1954cited by this paper

• Peculiar Cat with Many Lives: PUMA in Viral Infections

  2026cites this paper
• PUMA and NOXA Expression in Tumor-Associated Benign Prostatic Epithelial Cells Are Predictive of Prostate Cancer Biochemical Recurrence

  2020cites this paper
• Context dependent role of p53 up-regulated modulator of apoptosis (puma) during liver degeneration and regeneration

  2016cites this paper
• Prognostic value of PUMA expression in patients with HBV-related hepatocellular carcinoma.

  2015cites this paper
• Prognostic value of PUMA expression in patients with HBV-related hepatocellular carcinoma.

  2015cites this paper
• BH3-Only Proteins in Cancer and Apoptosis

  2013cites this paper
• Prognostic Significance of PUMA in Pancreatic Ductal Adenocarcinoma

  2012cites this paper
• Puma, a critical mediator of cell death — one decade on from its discovery

  2012cites this paper
• Regulation of the BH3-only protein PUMA by growth factor signalling.

  2011cites this paper
• PUMA–mediated apoptosis drives chemical hepatocarcinogenesis in mice

  2011cites this paper
• p53-insensitive PUMA down-regulation is essential in the early phase of liver regeneration after partial hepatectomy in mice.

  2010cites this paper
• Novel therapeutic targeting of apoptosis and survival pathways in melanoma

  2008cites this paper