Lubricin: a versatile, biological anti-adhesive with properties comparable to polyethylene glycol.

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Biomaterials

• Publication date

  2015-06-01

• Fields of study

  Biology, Medicine, Materials Science, Chemistry

• Identifiers
  DOI 10.1016/j.biomaterials.2015.02.086PMID 25890713
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Lubricin: a novel means to decrease bacterial adhesion and proliferation.

  2015cited by this paper
• PEGylation of platinum bio-electrodes

  2013cited by this paper
• Plasma proteins adsorption mechanism on polyethylene-grafted poly(ethylene glycol) surface by quartz crystal microbalance with dissipation.

  2013cited by this paper
• Controlled protein absorption and cell adhesion on polymer-brush-grafted poly(3,4-ethylenedioxythiophene) films.

  2013cited by this paper
• Synergistic interactions between grafted hyaluronic acid and lubricin provide enhanced wear protection and lubrication.

  2013cited by this paper
• Hyaluronic acid–collagen network interactions during the dynamic compression and recovery of cartilage

  2012cited by this paper
• The boundary lubrication of chemically grafted and cross-linked hyaluronic acid in phosphate buffered saline and lipid solutions measured by the surface forces apparatus.

  2012cited by this paper
• Protein resistant properties of polymers with different branched architecture on a gold surface

  2012cited by this paper
• From the Cover: Adaptive mechanically controlled lubrication mechanism found in articular joints

  2011cited by this paper
• Poly(ethylene oxide) layers grafted to dopamine-melanin anchoring layer: stability and resistance to protein adsorption.

  2011cited by this paper
• Comparative advantages of mechanical biosensors.

  2011cited by this paper
• Adhesion of microorganisms to bovine submaxillary mucin coatings: effect of coating deposition conditions

  2010cited by this paper
• The glycosylation of human synovial lubricin: implications for its role in inflammation.

  2010cited by this paper
• Protein adsorption onto polyelectrolyte layers: effects of protein hydrophobicity and charge anisotropy.

  2010cited by this paper
• Friction Force Microscopy of Lubricin and Hyaluronic Acid between Hydrophobic and Hydrophilic Surfaces.

  2009cited by this paper
• Reduction of Non-Specific Protein Adsorption Using Poly(ethylene) Glycol (PEG) Modified Polyacrylate Hydrogels In Immunoassays for Staphylococcal Enterotoxin B Detection

  2009cited by this paper
• Self-assembling polystyrene-block-poly(ethylene oxide) copolymer surface coatings: resistance to protein and cell adhesion.

  2009cited by this paper
• Molecular aspects of boundary lubrication by human lubricin: effect of disulfide bonds and enzymatic digestion.

  2008cited by this paper
• QCM-D analysis of the performance of blocking agents on gold and polystyrene surfaces.

  2008cited by this paper
• Antiadhesive character of mucin O-glycans at the apical surface of corneal epithelial cells.

  2008cited by this paper
• Conformational mechanics, adsorption, and normal force interactions of lubricin and hyaluronic acid on model surfaces.

  2008cited by this paper
• Adsorption, lubrication, and wear of lubricin on model surfaces: polymer brush-like behavior of a glycoprotein.

  2007cited by this paper
• Association between friction and wear in diarthrodial joints lacking lubricin

  2007cited by this paper
• Lithographic techniques and surface chemistries for the fabrication of PEG-passivated protein microarrays.

  2006cited by this paper
• Protein binding properties of surface-modified porous polyethylene membranes.

  2005cited by this paper
• The secreted glycoprotein lubricin protects cartilage surfaces and inhibits synovial cell overgrowth.

  2005cited by this paper
• Mucin-chitosan complexes at the solid-liquid interface: multilayer formation and stability in surfactant solutions.

  2005cited by this paper
• Protein adsorption modalities on polyelectrolyte multilayers.

  2004cited by this paper
• Lubricin and surfacing of articular joints

  2004cited by this paper
• Anti-adhesive glycoproteins in echinoderm mucus secretions.

  2004cited by this paper
• About the role of water in surface-grafted poly(ethylene glycol) layers.

  2004cited by this paper
• Quartz crystal microbalance: a useful tool for studying thin polymer films and complex biomolecular systems at the solution-surface interface.

  2003cited by this paper
• RGD-grafted poly-L-lysine-graft-(polyethylene glycol) copolymers block non-specific protein adsorption while promoting cell adhesion.

  2003cited by this paper
• Direct Measurement of Interactions between Tethered Poly(ethylene glycol) Chains and Adsorbed Mucin Layers

  2002cited by this paper
• Missing mass effect in biosensor's QCM applications.

  2002cited by this paper
• Development and characterization of an ELISA assay in PDMS microfluidic channels

  2001cited by this paper
• Boundary lubrication by lubricin is mediated by O-linked β(1-3)Gal-GalNAc oligosaccharides

  2001cited by this paper
• A Survey of Structure−Property Relationships of Surfaces that Resist the Adsorption of Protein

  2001cited by this paper
• Mucin Coating on Polymeric Material Surfaces to Suppress Bacterial Adhesion

  2000cited by this paper
• Polyethylene glycol-coated biocompatible surfaces.

  2000cited by this paper
• Viscoelastic Acoustic Response of Layered Polymer Films at Fluid-Solid Interfaces: Continuum Mechanics Approach

  1998cited by this paper
• Effect of MUC1 Mucin, an Anti‐adhesion Molecule, on Tumor Cell Growth

  1996cited by this paper
• Inhibition of cell adhesion by anti-adhesive molecules.

  1995cited by this paper
• Biochemistry of carbohydrate‐protein interaction 1

  1992cited by this paper
• The use of graft copolymers to inhibit the adhesion of bacteria to solid surfaces

  1987cited by this paper
• Data for Biochemical Research

  1986cited by this paper

• Self-assembled Lubricin (PRG-4) coating enabled biomimetic-DNA sensor for rapid detection of target DNA in undiluted milk

  2025cites this paper
• Leveraging Polymeric Design for Marine Anti‐Biofouling: Mechanism, System, and Future

  2025cites this paper
• Point-of-Need PFAS Detection: A Yes/No Biosensor Solution.

  2025cites this paper
• Native biolubricants mucin and lubricin: Comparative study of lubrication origins, synergy lubrication and molecularly mimicked biolubricants.

  2025cites this paper
• Bioinspired Zwitterionic Lubrication Coating with Bridge Architecture for Anticoagulation and Endothelialization of Blood-Contacting Implants via Interfacial Force Regulation.

  2025cites this paper
• Perils of the PICC: Peripherally Inserted Central Catheter-Associated Complications and Recommendations for Prevention in Clinical Practice—A Narrative Review

  2025cites this paper
• Impact of Surface Biofouling on Controlled Drug Release from Conductive Polymer Films and Its Mitigation Using Lubricin (Proteoglycan 4) Antifouling Coatings.

  2025cites this paper
• A Scalable Synthetic Approach for Producing Homogeneous, Large Area 2D Highly Conductive Polymers.

  2025cites this paper
• Resolving the Effects of Hydration and Salt Bridges on Protein Adhesion Resistance of Zwitterionic Polymer Brushes via AFM/MD.

  2025cites this paper
• The role of lubrication in function and degeneration of articular cartilage: a critical review and perspectives

  2025cites this paper
• Lubricin’s Mucin Domain Has Strong Polyproline Type-II Helical Character

  2025cites this paper
• Lubricin (PRG4) antifouling coating enables the development of an immunosensor for the detection of nerve growth factor in cell culture media.

  2025cites this paper
• Antibiofouling Coatings For Marine Sensors: Progress and Perspectives on Materials, Methods, Impacts, and Field Trial Studies

  2025cites this paper
• Advanced Control Strategies of Membrane Fouling in Wastewater Treatment: A Review

  2024cites this paper
• Self-Assembled Lubricin (PRG-4)-Based Biomimetic Surface-Enhanced Raman Scattering Sensor for Direct Droplet Detection of Melamine in Undiluted Milk

  2024cites this paper
• Toward low-friction and high-adhesion solutions: Emerging strategies for nanofibrous scaffolds in articular cartilage engineering.

  2024cites this paper
• Micromechanical characterization of zwitterionic polymer brushes based on the atomic force microscopy

  2024cites this paper
• Recombinant manufacturing of multispecies biolubricants

  2024cites this paper
• Biphasic Nanocomposite Films of Polypyrrole and Poly(3,4-ethylene dioxythiophene) Using a Surface-Tethered Dopant Strategy

  2024cites this paper
• Antifouling strategies for electrochemical sensing in complex biological media

  2024cites this paper
• Calcium ions have a detrimental impact on the boundary lubrication property of hyaluronic acid and lubricin (PRG-4) both alone and in combination.

  2024cites this paper
• Anti-fouling coatings for blood-contacting devices

  2024cites this paper
• Anti-biofouling laser-scribed graphene electrochemical sensor for reliable detection of uric acid in human saliva

  2023cites this paper
• Lubricin (PRG-4) anti-fouling coating for surface-enhanced Raman spectroscopy biosensing: towards a hierarchical separation system for analysis of biofluids.

  2023cites this paper
• Comparing polymer-surfactant complexes to polyelectrolytes.

  2023cites this paper
• A structural and functional comparison between two recombinant human lubricin proteins: Recombinant human proteoglycan-4 (rhPRG4) vs ECF843.

  2023cites this paper
• A surface-tethered dopant method to achieve 3D control over the growth of a nanometers-thin and intrinsically transparent polypyrrole film

  2023cites this paper
• Highly specific lubricin-lectin electrochemical sensor for glycoprotein cancer biomarker detection

  2023cites this paper
• Peptide Self-Assembly into Amyloid Fibrils at Hard and Soft Interfaces - From Corona Formation to Membrane Activity.

  2023cites this paper
• O-glycans Expand Lubricin and Attenuate Its Viscosity and Shear Thinning

  2023cites this paper
• Design, preparation, and characterization of lubricating polymer brushes for biomedical applications.

  2023cites this paper
• Novel Boundary Lubrication Mechanisms from Molecular Pillows of Lubricin Brush-Coated Graphene Oxide Nanosheets.

  2022cites this paper
• Bioinspired Surface Functionalization of Poly(ether ether ketone) for Enhancing Osteogenesis and Bacterial Resistance.

  2022cites this paper
• Quadruped Gait and Regulation of Apoptotic Factors in Tibiofemoral Joints following Intra-Articular rhPRG4 Injection in Prg4 Null Mice

  2022cites this paper
• Conformation-dominated surface antifouling and aqueous lubrication.

  2022cites this paper
• Lubricants for osteoarthritis treatment: From natural to bioinspired and alternative strategies.

  2022cites this paper
• Rapid Point-of-Care Electrochemical Sensor for the Detection of Cancer Tn Antigen Carbohydrate in Whole Unprocessed Blood.

  2022cites this paper
• Mussel-inspired polymeric coatings with the antifouling efficacy controlled by topologies.

  2022cites this paper
• Active and passive drug release by self-assembled lubricin (PRG4) anti-fouling coatings.

  2022cites this paper
• Fundamentals and Applications of Polymer Brushes in Air

  2022cites this paper
• Recombinant lubricin improves anti-adhesive, wear protection, and lubrication of collagen II surface.

  2022cites this paper
• Effect of Recombinant Human Lubricin on Model Tear Film Stability

  2022cites this paper
• Creating polysaccharide-protein complexes to control aqueous lubrication

  2021cites this paper
• Self-adhesive lubricated coating for enhanced bacterial resistance

  2021cites this paper
• Lubricin as a tool for controlling adhesion in vivo and ex vivo.

  2021cites this paper
• Recent Progress in Cartilage Lubrication

  2021cites this paper
• Antifouling Strategies for Electrochemical Biosensing: Mechanisms and Performance toward Point of Care Based Diagnostic Applications.

  2021cites this paper
• Bioinspired double self-adhesion coating based on dopamine, coating resin and phosphorylcholine for surface lubrication and antifouling functionalization

  2021cites this paper
• Effect of Hydrophobicity and Charge Separation on the Antifouling Properties of Surface-Tethered Zwitterionic Peptides.

  2021cites this paper
• Cellular Interactions with Lubricin and Hyaluronic Acid-Lubricin Composite Coatings on Gold Electrodes in Passive and Electrically Stimulated Environments.

  2021cites this paper
• Potential Pulse-Facilitated Active Adsorption of Lubricin Polymer Brushes Can Both Accelerate Self-Assembly and Control Grafting Density.

  2021cites this paper
• Spray Coating of 2‐ and 3‐D Solid Substrates Using a Sulfated Polysaccharide for Marine Antifouling Applications

  2021cites this paper
• Hydrogen-Bonded Structure of Water in the Loop of Anchored Polyrotaxane Chain Controlled by Anchoring Density

  2021cites this paper
• Zwitterionic polymer modified xanthan gum with collagen II-binding capability for lubrication improvement and ROS scavenging.

  2021cites this paper
• Evaluation of the effects of nicotine on the friction of the articular cartilage and the reversion of the estrogen in vitro

  2021cites this paper
• Preparation and Property Study of Organosilicon Antisticking Coatings

  2020cites this paper
• Slippery when wet: The free surface of the articular cartilage

  2020cites this paper
• Lubricin (PRG4) Antiadhesive Coatings Mitigate Electrochemical Impedance Instabilities in Polypyrrole Bionic Electrodes Exposed to Fouling Fluids.

  2020cites this paper
• Self-Assembly of Lubricin (PRG-4) Brushes on Graphene Oxide Affords Stable 2D-Nanosheets in Concentrated Electrolytes and Complex Fluids

  2020cites this paper
• Highly selective and antifouling electrochemical biosensors for sensitive MicroRNA assaying based on conducting polymer polyaniline functionalized with zwitterionic peptide

  2020cites this paper
• Modeling and Restoring the Tear Film

  2020cites this paper
• Biopolymer‐Based Coatings: Promising Strategies to Improve the Biocompatibility and Functionality of Materials Used in Biomedical Engineering

  2020cites this paper
• Understanding the adsorption and potential tear film stability properties of recombinant human lubricin and bovine submaxillary mucins in an in vitro tear film model.

  2020cites this paper
• Recent Developments and Practical Feasibility of Polymer‐Based Antifouling Coatings

  2020cites this paper
• A Simple Electrochemical Swab Assay for the Rapid Quantification of Clonazepam in Unprocessed Saliva Enabled by Lubricin Antifouling Coatings

  2020cites this paper
• Mussel-Inspired Copolyether Loop with Superior Antifouling Behavior

  2020cites this paper
• Mussel‐Inspired Hydrogels for Self‐Adhesive Bioelectronics

  2020cites this paper
• Structures and Antifouling Properties of Self-assembled Zwitterionic Peptide Monolayers: Effects of Peptide Charge Distributions and Divalent Cations.

  2020cites this paper
• Lubricin (PRG4) reduces fouling susceptibility and improves sensitivity of carbon-based electrodes

  2020cites this paper
• Grafting To of Bottlebrush Polymers: Conformation and Kinetics.

  2020cites this paper
• Zwitterionic Peptide Enhances Protein-Resistant Performance of Hyaluronic Acid-Modified Surfaces.

  2020cites this paper
• Synergy between zwitterionic polymers and hyaluronic acid enhances antifouling performance.

  2019cites this paper
• Lubricin on Platinum Electrodes: A Low‐Impedance Protein‐Resistant Surface Towards Biomedical Implantation

  2019cites this paper
• Probing the Molecular Interactions and Lubrication Mechanisms of Purified Full-Length Recombinant Human Proteoglycan 4 (rhPRG4) and Hyaluronic Acid (HA).

  2019cites this paper
• A novel membrane biofouling mitigation strategy of D-amino acid supported by polydopamine and halloysite nanotube

  2019cites this paper
• Interactions between Lubricin and Hyaluronic Acid Synergistically Enhance Antiadhesive Properties.

  2019cites this paper
• The Adsorption of Amyloidogenic Peptides to Functionalized Surfaces Is Biased by Charge and Hydrophilicity.

  2019cites this paper
• The adhesion and self-assembly of lubricin (PRG4) brush layers on different substrate surfaces.

  2019cites this paper
• Lubricin Antiadhesive Coatings Exhibit Size‐Selective Transport Properties that Inhibit Biofouling of Electrode Surfaces with Minimal Loss in Electrochemical Activity

  2018cites this paper
• Molecularly Engineered Biolubricants for Articular Cartilage

  2018cites this paper
• Understanding Effects of PAMAM Dendrimer Size and Surface Chemistry on Serum Protein Binding with Discrete Molecular Dynamics Simulations.

  2018cites this paper
• Two compartment pharmacokinetic model describes the intra‐articular delivery and retention of rhprg4 following ACL transection in the Yucatan mini pig

  2018cites this paper
• Biomimetic Bottlebrush Polymer Coatings for Fabrication of Ultralow Fouling Surfaces.

  2018cites this paper
• Surface-Functionalized Model Contact Lenses with a Bioinspired Proteoglycan 4 (PRG4)-Grafted Layer.

  2018cites this paper
• Adsorption-Desorption Behavior of Black Phosphorus Quantum Dots on Mucin Surface.

  2018cites this paper
• Hairy and Slippery Polyoxazoline-Based Copolymers on Model and Cartilage Surfaces.

  2018cites this paper
• Effect of End-Grafted Polymer Conformation on Protein Resistance.

  2018cites this paper
• Introduction of Nature's Complexity in Engineered Blood‐compatible Biomaterials

  2018cites this paper
• Biocompatible Elastic Conductive Films Significantly Enhanced Myogenic Differentiation of Myoblast for Skeletal Muscle Regeneration.

  2017cites this paper
• Structure and Property Changes in Self-Assembled Lubricin Layers Induced by Calcium Ion Interactions.

  2017cites this paper
• Mussel-Inspired Anchoring of Polymer Loops That Provide Superior Surface Lubrication and Antifouling Properties.

  2016cites this paper
• Design and mechanisms of antifouling materials for surface plasmon resonance sensors.

  2016cites this paper
• The slip agents oleamide and erucamide reduce biofouling by marine benthic organisms (diatoms, biofilms and abalones)

  2016cites this paper
• Tribology of surface-grafted polymer brushes

  2016cites this paper
• Electrokinetic Properties of Lubricin Antiadhesive Coatings in Microfluidic Systems.

  2016cites this paper
• Anti-fouling properties of Fab’ fragments immobilized on silane-based adlayers

  2015cites this paper
• Conjugation of Hyaluronic Acid onto Surfaces via the Interfacial Polymerization of Dopamine to Prevent Protein Adsorption.

  2015cites this paper
• Fabrication of Microcontroller Based Dip-Casting for Thin Films Depositions

  2015cites this paper
• Superior Antifouling Performance of a Zwitterionic Peptide Compared to an Amphiphilic, Non-Ionic Peptide.

  2015cites this paper