Physiological application of nanoparticles in calcium-related proteins and channels.

Nanoparticles (NPs) have been studied as therapeutic drug-delivery agents for promising clinical trial outcomes. Nanomaterial-based drugs can transfer conventional drugs to target lesions, such as tumors, with increasing efficiency by enhancing drug-cell interaction or drug absorption. Although they are favorable as efficient drug transfer systems, NPs also exhibit cytotoxicity that affects nonpathological regions. Here, we review the basic information behind NP-induced Ca2+ signaling and its participation in channel physiology and pathology. NPs are observed to demonstrate inhibitory or active effects on Ca2+ signaling. Thus, understanding Ca2+ signaling by NPs as a key mechanism in signal transduction will progress the application of nano-drugs in various diseases without deleterious effect.

• Publication year

  2019

• Venue

  Nanomedicine

• Publication date

  2019-08-28

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.2217/nnm-2019-0004PMID 31456482
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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