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Epidemiological, pathological, and immunohistochemical aspects of 125 cases of feline lymphoma in southern brazil.

R. V. Leite-Filho,W. Panziera,M. Bandinelli,L. Henker,Kalinka da Conceição Monteiro,L. Corbellini,D. Driemeier,L. Sonne,S. Pavarini

Published 2020 in Veterinary and Comparative Oncology

ABSTRACT

A retrospective study compiling cases of feline lymphoma diagnosed during 12 years (2004-2016) in Southern Brazil was performed. A total of 125 cases of lymphoma diagnosed in cats were reviewed, and information including age, breed, sex, and tumor topography were collected. FeLV and FIV immunohistochemical tests were performed, as well as immunophenotyping of lymphomas. The alimentary form represented the most common presentation (42/125), followed by mediastinal lymphoma (35/125). Out of 125 cases, 79 presented positive retroviral immunostaining in tumor tissue (52 FeLV alone, 14 FIV alone, and 13 presented FIV and FeLV coinfections), 66/125 of the cases were of T-cell origin, and 59/125 of the cases were of B-cell origin. The median age of cats with T-cell lymphoma was 120 months (10 to 240 months), and 60 months (6 to 204 months) for cats with B-cell lymphoma. The most frequent alimentary tumor presentation was the enteropathy-associated T-cell lymphoma (type 1), and the major type of mediastinal tumor observed was diffuse large B-cell lymphoma. Considering only mediastinal lymphomas, its prevalence in FeLV-positive cats was 3.2 times higher than the prevalence of this type of tumor in FeLV-negative cats (p=0.036). Mediastinal lymphoma was more frequently observed in younger cats, and the prevalence of mediastinal tumors in these animals was 4.06 the prevalence of this tumor form in old cats (p=0.0125). The present study indicates that retroviral infections still play an important role in the development of feline lymphomas in southern Brazil. This article is protected by copyright. All rights reserved.

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