Lipopolysaccharide exposure in a rat sepsis model results in hippocampal amyloid-β plaque and phosphorylated tau deposition and corresponding behavioral deficits

No abstract is available for this paper.

• Publication year

  2019

• Venue

  GeroScience

• Publication date

  2019-08-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/s11357-019-00089-9PMID 31473912PMCID PMC6815307
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Low-grade systemic inflammation is associated with functional disability in elderly people affected by dementia

  2018cited by this paper
• The role of adult hippocampal neurogenesis in brain health and disease

  2018cited by this paper
• Long-Term Cognitive Outcomes After Sepsis: a Translational Systematic Review

  2018cited by this paper
• Lipopolysaccharide endotoxemia induces amyloid-β and p-tau formation in the rat brain.

  2018influential reference
• Candidate molecular pathways of white matter vulnerability in the brain of normal aging rhesus monkeys

  2018cited by this paper
• Assessing long-term neuroinflammatory responses to encephalopathy using MRI approaches in a rat endotoxemia model

  2018cited by this paper
• Entorhinal Tau Pathology, Episodic Memory Decline, and Neurodegeneration in Aging

  2017cited by this paper
• Association of increased gait variability while dual tasking and cognitive decline: results from a prospective longitudinal cohort pilot study

  2017cited by this paper
• 18F-fluoro-2-deoxyglucose PET informs neutrophil accumulation and activation in lipopolysaccharide-induced acute lung injury.

  2017cited by this paper
• Cerebromicrovascular dysfunction predicts cognitive decline and gait abnormalities in a mouse model of whole brain irradiation-induced accelerated brain senescence

  2017cited by this paper
• Microglia activation and phagocytosis: relationship with aging and cognitive impairment in the rhesus monkey

  2017cited by this paper
• Septic Shock and the Aging Process: A Molecular Comparison

  2017cited by this paper
• Septicemia is associated with increased risk for dementia: a population-based longitudinal study

  2017cited by this paper
• Alzheimer's Disease and Hippocampal Adult Neurogenesis; Exploring Shared Mechanisms

  2016cited by this paper
• Role of the dentate gyrus in mediating object-spatial configuration recognition.

  2015cited by this paper
• Early Structural and Functional Defects in Synapses and Myelinated Axons in Stratum Lacunosum Moleculare in Two Preclinical Models for Tauopathy

  2014cited by this paper
• Neurogenesis in the Normal Ageing Hippocampus: A Mini-Review

  2014cited by this paper
• Assessing spatial learning and memory in rodents.

  2014cited by this paper
• Memory loss in Alzheimer's disease

  2013cited by this paper
• Temporal associations for spatial events: the role of the dentate gyrus.

  2013cited by this paper
• Distinct roles of medial and lateral entorhinal cortex in spatial cognition.

  2013cited by this paper
• The role of the dorsal dentate gyrus in object and object-context recognition.

  2013cited by this paper
• Trans-Synaptic Spread of Tau Pathology In Vivo

  2012cited by this paper
• Hippocampal neuronal loss in the CA1 and CA3 areas of Alzheimer's disease patients.

  2012cited by this paper
• Detection of Neuritic Plaques in Alzheimer's Disease Mouse Model

  2011cited by this paper
• Episodic memory on the path to Alzheimer's disease.

  2011cited by this paper
• Sepsis-associated encephalopathy: review of the neuropsychiatric manifestations and cognitive outcome.

  2011cited by this paper
• Long-term cognitive impairment and functional disability among survivors of severe sepsis.

  2010cited by this paper
• Lipopolysaccharide acutely inhibits proliferation of neural precursor cells in the dentate gyrus in adult rats.

  2010cited by this paper
• Transmission and spreading of tauopathy in transgenic mouse brain

  2009cited by this paper
• NCS-1 in the dentate gyrus promotes exploration, synaptic plasticity, and rapid acquisition of spatial memory.

  2009cited by this paper
• The interactions and dissociations of the dorsal hippocampus subregions: how the dentate gyrus, CA3, and CA1 process spatial information.

  2008cited by this paper
• Sepsis-associated delirium

  2007cited by this paper
• Spatial cognition and the human navigation network in AD and MCI

  2007cited by this paper
• Anti-Abeta42- and anti-Abeta40-specific mAbs attenuate amyloid deposition in an Alzheimer disease mouse model.

  2006cited by this paper
• The role of hippocampal subregions in detecting spatial novelty.

  2005cited by this paper
• Anti-Aβ42– and anti-Aβ40–specific mAbs attenuate amyloid deposition in an Alzheimer disease mouse model

  2005cited by this paper
• Quality of life, emotional, and cognitive function following acute respiratory distress syndrome

  2004cited by this paper
• Spatial disorientation in Alzheimer’s disease

  2003cited by this paper
• Neural stem cells and the regulation of neurogenesis in the adult hippocampus.

  2002cited by this paper
• Stability of the preclinical episodic memory deficit in Alzheimer's disease.

  2001cited by this paper
• Hyperphosphorylation induces self-assembly of τ into tangles of paired helical filaments/straight filaments

  2001cited by this paper
• Somatodendritic localization of phosphorylated tau in neonatal and adult rat cerebral cortex

  1997cited by this paper
• Regulation of mitochondrial pyruvate dehydrogenase activity by tau protein kinase I/glycogen synthase kinase 3beta in brain.

  1996cited by this paper
• Spatial disorientation in Alzheimer's disease.

  1989cited by this paper

• Short-term exposure to a high-fat diet leads to neuroinflammation and impairs memory and cholinergic signaling in the hippocampal CA3 region of male mice.

  2026cites this paper
• The brain washing system in sepsis-associated encephalopathy

  2025cites this paper
• CLIC1 and IFITM2 expression in brain tissue correlates with cognitive impairment via immune dysregulation in sepsis and Alzheimer's disease.

  2025cites this paper
• Potentiating Cerebral Perfusion Normalizes Glymphatic Dynamics in Systemic Inflammation

  2025cites this paper
• Tannic acid-derived carbon dots: Dual-function inhibitors against β-amyloid fibrosis and bacterial infections.

  2025cites this paper
• Region-specific neuroprotective effects of meldonium pretreatment in two models of sepsis-associated encephalopathy

  2025cites this paper
• A review on pathological implications and therapeutic interventions of sepsis-associated encephalopathy.

  2025cites this paper
• Neuroprotective effect of long‐term resistance physical exercise against memory damage elicited by a lipopolysaccharide‐induced neuroinflammation model in male rats

  2024cites this paper
• Erratum: SIRT3-mediated mitochondrial autophagy in refeeding syndrome-related myocardial injury in sepsis rats

  2024cites this paper
• Cutibacterium Acnes induces Alzheimer’s disease-like pathology in brains of wistar rats through structural changes associated with microtubules

  2024cites this paper
• Natural products: Harnessing the power of gut microbiota for neurological health.

  2024cites this paper
• A TNF-α inhibitor abolishes sepsis-induced cognitive impairment in mice by modulating acetylcholine and nitric oxide homeostasis, BDNF release, and neuroinflammation.

  2024cites this paper
• Neurochemical effects of sepsis on the brain.

  2023cites this paper
• Research Progress of Biomarkers of Sepsis-Associated Encephalopathy

  2023cites this paper
• White matter injury, cholesterol dysmetabolism, and APP/Abeta dysmetabolism interact to produce Alzheimer’s disease (AD) neuropathology: A hypothesis and review

  2023cites this paper
• Cathelicidin downregulates neurotensin and substance P hippocampal levels

  2023cites this paper
• CIRCTDRD9 CONTRIBUTES TO SEPSIS-INDUCED ACUTE LUNG INJURY BY ENHANCING THE EXPRESSION OF RAB10 VIA DIRECTLY BINDING TO MIR-223-3P

  2023cites this paper
• The Neurobiology and Therapeutic Potential of Multi-Targeting β-secretase, Glycogen Synthase Kinase 3β and Acetylcholinesterase in Alzheimer's Disease.

  2023cites this paper
• Acute and long-term cognitive impairment following sepsis: mechanism and prevention

  2023cites this paper
• Investigation for the involvement of microbial FliC and DING proteins in Alzheimer's Disease and Mild Cognitive Impairment and correlation with neurodegeneration and inflammation markers

  2023cites this paper
• In-Hospital Neurologic Complications, Neuromonitoring, and Long-Term Neurologic Outcomes in Patients With Sepsis: A Systematic Review and Meta-Analysis

  2023cites this paper
• Morphine aggravates inflammatory, behavioral, and hippocampal structural deficits in septic rats

  2023cites this paper
• Exacerbated Immune Response of the Brain to Peripheral Immune Challenge in Post-Septic Mice.

  2022cites this paper
• SIRT3-mediated mitochondrial autophagy in refeeding syndrome-related myocardial injury in sepsis rats

  2022cites this paper
• Avanafil mediated dual inhibition of IKKβ and TNFR1 in an experimental paradigm of Alzheimer’s disease: in silico and in vivo approach

  2022cites this paper
• The Interplay between Meningeal Lymphatic Vessels and Neuroinflammation in Neurodegenerative Diseases

  2022cites this paper
• Aspirin reverts lipopolysaccharide-induced learning and memory impairment: first evidence from an invertebrate model system

  2022cites this paper
• Microglial Priming in Infections and Its Risk to Neurodegenerative Diseases

  2022cites this paper
• Sepsis-associated brain injury: underlying mechanisms and potential therapeutic strategies for acute and long-term cognitive impairments

  2022cites this paper
• Insight Into Regulatory T Cells in Sepsis-Associated Encephalopathy

  2022cites this paper
• Eugenitol ameliorates memory impairments in 5XFAD mice by reducing Aβ plaques and neuroinflammation.

  2022cites this paper
• A binge high sucrose diet provokes systemic and cerebral inflammation in rats without inducing obesity

  2021cites this paper
• Gram-negative bacteria and their lipopolysaccharides in Alzheimer’s disease: pathologic roles and therapeutic implications

  2021cites this paper
• Recent Insights Into the Protective Mechanisms of Paeoniflorin in Neurological, Cardiovascular, and Renal Diseases

  2021cites this paper
• Ubiquitin Ligase COP1 Suppresses Neuroinflammation by Degrading c/EBPβ in Microglia.

  2020cites this paper
• Inflammation-Induced Attenuation of Prostaglandin D2 Elimination across Rat Blood-Brain Barrier: Involvement of the Downregulation of Organic Anion Transporter 3 and Multidrug Resistance-Associated Protein 4.

  2020cites this paper
• Obesity-induced Cognitive Impairment in Older Adults: a Microvascular Perspective.

  2020cites this paper
• Glaucocalyxin A alleviates LPS-mediated septic shock and inflammation via inhibiting NLRP3 inflammasome activation.

  2020cites this paper
• Interleukin 6 reduces allopregnanolone synthesis in the brain and contributes to age-related cognitive decline in mice

  2020cites this paper
• Anti-inflammatory agent, OKN-007, reverses long-term neuroinflammatory responses in a rat encephalopathy model as assessed by multi-parametric MRI: implications for aging-associated neuroinflammation

  2019cites this paper