Ischemic Neuroprotectant PKCε Restores Mitochondrial Glutamate Oxaloacetate Transaminase in the Neuronal NADH Shuttle after Ischemic Injury

No abstract is available for this paper.

• Publication year

  2019

• Venue

  Translational Stroke Research

• Publication date

  2019-08-31

• Fields of study

  Medicine

• Identifiers
  DOI 10.1007/s12975-019-00729-4PMID 31473978PMCID PMC7048657
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• A Proof of Concept Randomized Controlled Trial of the Canopie Programme: A Brief Digital Intervention for Addressing Postpartum Depression

  2021cited by this paper
• Heart Disease and Stroke Statistics—2019 Update: A Report From the American Heart Association

  2019cited by this paper
• Negative Conditioning of Mitochondrial Dysfunction in Age-related Neurodegenerative Diseases.

  2019cited by this paper
• Effects of ischemic preconditioning on mitochondrial and metabolic neruoprotection: 5’ adenosine monophosphate-activated protein kinase and sirtuins

  2018cited by this paper
• Ischemic conditioning in organ transplantation

  2018cited by this paper
• Metabolomics Based Identification of SIRT5 and Protein Kinase C Epsilon Regulated Pathways in Brain

  2018cited by this paper
• Remote Ischemic Postconditioning for Ischemic Stroke: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

  2018cited by this paper
• Mitochondrial dynamics and preconditioning in white matter.

  2018cited by this paper
• Genetic inhibition of PKCε attenuates neurodegeneration after global cerebral ischemia in male mice

  2018cited by this paper
• Resveratrol Preconditioning Induces Genomic and Metabolic Adaptations within the Long-Term Window of Cerebral Ischemic Tolerance Leading to Bioenergetic Efficiency

  2018cited by this paper
• Glutamate oxaloacetate transaminase enables anaplerotic refilling of TCA cycle intermediates in stroke‐affected brain

  2017cited by this paper
• Neuronal SIRT1 (Silent Information Regulator 2 Homologue 1) Regulates Glycolysis and Mediates Resveratrol-Induced Ischemic Tolerance

  2017cited by this paper
• Safety and Efficacy of Remote Ischemic Preconditioning in Patients With Severe Carotid Artery Stenosis Before Carotid Artery Stenting: A Proof-of-Concept, Randomized Controlled Trial

  2017cited by this paper
• ARALAR/AGC1 deficiency, a neurodevelopmental disorder with severe impairment of neuronal mitochondrial respiration, does not produce a primary increase in brain lactate

  2017cited by this paper
• The NAD+-Dependent Family of Sirtuins in Cerebral Ischemia and Preconditioning

  2017cited by this paper
• Protein Kinase C Epsilon Promotes Cerebral Ischemic Tolerance Via Modulation of Mitochondrial Sirt5

  2016cited by this paper
• Differential Aspartate Usage Identifies a Subset of Cancer Cells Particularly Dependent on OGDH.

  2016cited by this paper
• Normalization of NAD+ Redox Balance as a Therapy for Heart Failure

  2016cited by this paper
• An Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate Synthesis.

  2015cited by this paper
• Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS

  2014cited by this paper
• Protein Kinase C Epsilon Regulates Mitochondrial Pools of Nampt and NAD Following Resveratrol and Ischemic Preconditioning in the Rat Cortex

  2014cited by this paper
• Mitochondrial Dysfunction and NAD+ Metabolism Alterations in the Pathophysiology of Acute Brain Injury

  2013cited by this paper
• Glutamine supports pancreatic cancer growth through a Kras-regulated metabolic pathway

  2013cited by this paper
• Calcium-Regulation of Mitochondrial Respiration Maintains ATP Homeostasis and Requires ARALAR/AGC1-Malate Aspartate Shuttle in Intact Cortical Neurons

  2013cited by this paper
• The mitochondrial oxoglutarate carrier: from identification to mechanism

  2013cited by this paper
• Epsilon PKC Increases Brain Mitochondrial SIRT1 Protein Levels via Heat Shock Protein 90 following Ischemic Preconditioning in Rats

  2013cited by this paper
• Quantitative clinical proteomic study of autopsied human infarcted brain specimens to elucidate the deregulated pathways in ischemic stroke pathology.

  2013cited by this paper
• Lymphocyte Cell Kinase Activation Mediates Neuroprotection during Ischemic Preconditioning

  2012cited by this paper
• Effects of fatty acids on cardioprotection by pre‐ischaemic inhibition of the malate–aspartate shuttle

  2012cited by this paper
• A simple protocol for the subcellular fractionation of skeletal muscle cells and tissue

  2012cited by this paper
• Post-ischemic activation of protein kinase C ε protects the hippocampus from cerebral ischemic injury via alterations in cerebral blood flow.

  2011cited by this paper
• Neuroprotection by glutamate oxaloacetate transaminase in ischemic stroke: An experimental study

  2011cited by this paper
• VEGF up-regulation by G93A superoxide dismutase and the role of malate-aspartate shuttle inhibition.

  2010cited by this paper
• Time-dependent alterations of cerebral proteins following short-term normobaric hyperoxia

  2010cited by this paper
• Ischemic Preconditioning Mediates Cyclooxygenase-2 Expression Via Nuclear Factor-Kappa B Activation in Mixed Cortical Neuronal Cultures

  2010cited by this paper
• Amino acid transamination is crucial for ischaemic cardioprotection in normal and preconditioned isolated rat hearts – focus on l‐glutamate

  2010cited by this paper
• Inhibition of the malate-aspartate shuttle by pre-ischaemic aminooxyacetate loading of the heart induces cardioprotection.

  2010cited by this paper
• Mitochondrial import of PKCε is mediated by HSP90: a role in cardioprotection from ischaemia and reperfusion injury

  2010cited by this paper
• Proteomic and metabolomic analysis of cardioprotection: Interplay between protein kinase C epsilon and delta in regulating glucose metabolism of murine hearts.

  2009cited by this paper
• Dietary branched chain amino acids ameliorate injury-induced cognitive impairment

  2009cited by this paper
• Disruption of Mitochondrial Malate-Aspartate Shuttle Activity in Mouse Blastocysts Impairs Viability and Fetal Growth1

  2009cited by this paper
• Hypoxia activates NADPH oxidase to increase [ROS]i and [Ca2+]i through the mitochondrial ROS-PKCepsilon signaling axis in pulmonary artery smooth muscle cells.

  2008cited by this paper
• Ischemic Preconditioning Targets the Respiration of Synaptic Mitochondria via Protein Kinase Cε

  2008cited by this paper
• Neuronal and astrocytic shuttle mechanisms for cytosolic-mitochondrial transfer of reducing equivalents: current evidence and pharmacological tools.

  2006cited by this paper
• Essential Role of Aralar in the Transduction of Small Ca+ Signals to Neuronal Mitochondria*

  2006cited by this paper
• Epsilon protein kinase C as a potential therapeutic target for the ischemic heart.

  2006cited by this paper
• Identification of protein kinase C isoforms involved in cerebral hypoxic preconditioning of mice.

  2005cited by this paper
• The Role of Protein Kinase C in Cerebral Ischemic and Reperfusion Injury

  2005cited by this paper
• Pivotal role of NOX‐2‐containing NADPH oxidase in early ischemic preconditioning

  2005cited by this paper
• Epsilon Protein Kinase C Mediated Ischemic Tolerance Requires Activation of the Extracellular Regulated Kinase Pathway in the Organotypic Hippocampal Slice

  2004cited by this paper
• Identification of caspase-independent PKCepsilon-JNK/p38 MAPK signaling module in response to metabolic inhibition in H9c2 cells.

  2004cited by this paper
• Cell-specific role for epsilon- and betaI-protein kinase C isozymes in protecting cortical neurons and astrocytes from ischemia-like injury.

  2004cited by this paper
• Cell-specific role for ε- and βI-protein kinase C isozymes in protecting cortical neurons and astrocytes from ischemia-like injury

  2004cited by this paper
• εPKC Is Required for the Induction of Tolerance by Ischemic and NMDA-Mediated Preconditioning in the Organotypic Hippocampal Slice

  2003cited by this paper
• Formation of protein kinase C(epsilon)-Lck signaling modules confers cardioprotection.

  2002cited by this paper
• Mitochondrial PKCepsilon and MAPK form signaling modules in the murine heart: enhanced mitochondrial PKCepsilon-MAPK interactions and differential MAPK activation in PKCepsilon-induced cardioprotection.

  2002cited by this paper
• Formation of protein kinase Cε-Lck signaling modules confers cardioprotection

  2002cited by this paper
• Possible mechanism for the decrease of mitochondrial aspartate aminotransferase activity in ischemic and hypoxic rat retinas.

  1999cited by this paper
• Demonstration of selective protein kinase C-dependent activation of Src and Lck tyrosine kinases during ischemic preconditioning in conscious rabbits.

  1999cited by this paper
• PKC-dependent activation of p46/p54 JNKs during ischemic preconditioning in conscious rabbits.

  1999cited by this paper
• PKC-dependent activation of p46/p54 JNKs during ischemic preconditioning in conscious rabbits.

  1999cited by this paper
• Abundant bacterial expression and reconstitution of an intrinsic membrane-transport protein from bovine mitochondria.

  1993cited by this paper
• Regulation of energy metabolism in synaptic terminals and cultured rat brain astrocytes: differences revealed using aminooxyacetate.

  1993cited by this paper
• Aminooxyacetic acid inhibits the malate-aspartate shuttle in isolated nerve terminals and prevents the mitochondria from utilizing glycolytic substrates.

  1987cited by this paper
• Inhibition by (aminooxy)acetate of the malate-aspartate cycle in the isolated working guinea pig heart.

  1980cited by this paper
• Phosphorylation coupled to oxidation of dihydrodiphosphopyridine nucleotide.

  1951cited by this paper

• Ischemic stroke and cardiovascular comorbidity

  2026cites this paper
• Cigarette Smoking-Regulated PRKCE Is Involved in Bladder Cancer Susceptibility through cGMP/PKG-Dependent Glycolysis

  2025cites this paper
• GOT2: a moonlighting enzyme at the crossroads of cancer metabolism and theranostics

  2025cites this paper
• BIRC3 deficiency blocks the ubiquitination and degradation of GOT2 to impede antitumor immune responses in lung squamous cell carcinoma

  2025cites this paper
• Role of mitochondrial metabolism in ischemic stroke and natural products intervention

  2025cites this paper
• Post-cerebral ischemia energy crisis: the role of glucose metabolism in the energetic crisis

  2025cites this paper
• Uncoupling protein 3 protects against pathological cardiac hypertrophy via downregulation of aspartate.

  2025cites this paper
• NEW PERSPECTIVES IN NEUROPROTECTION FOR ISCHEMIC STROKE.

  2024cites this paper
• Buyang Huanwu Decoction restores the balance of mitochondrial dynamics after cerebral ischemia-reperfusion through calcium overload reduction by the PKCε-Nampt-Sirt5 axis.

  2024cites this paper
• Pantothenate-encapsulated liposomes combined with exercise for effective inhibition of CRM1-mediated PKM2 translocation in Alzheimer's therapy.

  2024cites this paper
• Preclinical validation of human recombinant glutamate-oxaloacetate transaminase for the treatment of acute ischemic stroke

  2024cites this paper
• Identification of the metabolic state of surviving cardiomyocytes in the human infarcted heart by spatial single-cell transcriptomics

  2023cites this paper
• Resveratrol Preconditioning Downregulates PARP1 Protein to Alleviate PARP1-Mediated Cell Death Following Cerebral Ischemia

  2023cites this paper
• Heat Shock Protein 90 as Therapeutic Target for CVDs and Heart Ageing

  2022cites this paper
• Oxaloacetate: signaling molecule, molecular mechanisms of interaction, prospects for clinical application

  2022cites this paper
• Aplysia Neurons as a Model of Alzheimer’s Disease: Shared Genes and Differential Expression

  2021cites this paper
• Deregulated Protein Kinases: Friend and Foe in Ischemic Stroke

  2021cites this paper
• Mitochondrial Metabolism behind Region-Specific Resistance to Ischemia-Reperfusion Injury in Gerbil Hippocampus. Role of PKCβII and Phosphate-Activated Glutaminase

  2021influential citation
• The Potential Relationship Between HIF-1α and Amino Acid Metabolism After Hypoxic Ischemia and Dual Effects on Neurons

  2021cites this paper
• Self-Regulation of Cerebral Metabolism and Its Neuroprotective Effect After Hypoxic-Ischemic Injury: Evidence From 1H-MRS

  2021cites this paper
• Metabolic Reprogramming: Strategy for Ischemic Stroke Treatment by Ischemic Preconditioning

  2021cites this paper
• Glucose metabolic crosstalk and regulation in brain function and diseases.

  2021cites this paper
• Paternal Zn-deficiency abolishes metabolic effects in offspring induced by diet type

  2021cites this paper