Fructose 2,6-bisphosphate and the control of glycolysis by growth factors, tumor promoters and oncogenes.

No abstract is available for this paper.

• Publication year

  1993

• Venue

  Advances in Enzyme Regulation

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/0065-2571(93)90011-2PMID 8395137
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Fructose 2,6-bisphosphate.

  2006cited by this paper
• The Warburg hypothesis fifty years later

  2004cited by this paper
• Mammalian 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase: a bifunctional enzyme that controls glycolysis.

  1993cited by this paper
• Evidence for new phosphorylation sites for protein kinase C and cyclic AMP‐dependent protein kinase in bovine heart 6‐phosphofructo‐2‐kinase/fructose‐2,6‐bisphosphatase

  1992cited by this paper
• Effects of epidermal growth factor on glycolysis in A431 cells.

  1992cited by this paper
• The two forms of bovine heart 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase result from alternative splicing.

  1992cited by this paper
• Inhibition of 6-phosphofructo-2-kinase activity by mercaptopurines.

  1992cited by this paper
• Characterization of 6-phosphofructo-2-kinase from foetal-rat liver.

  1992cited by this paper
• Stimulation of glycolysis as an activation signal in rat peritoneal macrophages. Effect of glucocorticoids on this process.

  1992cited by this paper
• Phorbol esters, bombesin and insulin elicit differential responses on the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase system in primary cultures of foetal and adult rat hepatocytes.

  1992cited by this paper
• Activation of 6-phosphofructo-2-kinase by pp60v-src is an indirect effect.

  1992cited by this paper
• Molecular forms of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase expressed in rat skeletal muscle.

  1992cited by this paper
• A rat gene encoding heart 6‐phosphofructo‐2‐kinase/fructose‐2,6‐bisphosphatase

  1991cited by this paper
• Hormonal control of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene expression in rat hepatoma cells.

  1991cited by this paper
• Molecular cloning of the DNA and expression and characterization of rat testes fructose-6-phosphate,2-kinase:fructose-2,6-bisphosphatase.

  1991cited by this paper
• Effect of TPA on fructose 2,6-bisphosphate levels and protein kinase C activity in B-chronic lymphocytic leukemia (B-CLL).

  1991cited by this paper
• The impairment of respiration by glycolysis in the Lewis lung carcinoma.

  1990cited by this paper
• Bovine heart fructose-6-phosphate 2-kinase/fructose-2,6-bisphosphatase: complete amino acid sequence and localization of phosphorylation sites.

  1990cited by this paper
• Phosphofructokinase 2 and glycolysis in HT29 human colon adenocarcinoma cell line. Regulation by insulin and phorbol esters.

  1990cited by this paper
• Contrasting effects of the protein kinase C inhibitor, staurosporine, on cytokine and phorbol ester stimulation of fructose 2,6-bisphosphate and prostaglandin E production by fibroblasts in vitro. Comparative studies using interleukin-1 alpha, tumour necrosis factor alpha, transforming growth factor

  1990cited by this paper
• A phospho-oligosaccharide can reproduce the stimulatory effect of insulin on glycolytic flux in human fibroblasts.

  1990cited by this paper
• 6-Phosphofructo-2-Kinase Links Glycolysis to Mitogenic Agents and has Sequence Similarity with Proteins Encoded by Oncogenic DNA Viruses

  1990cited by this paper
• Insulin controls key steps of carbohydrate metabolism in cultured HT29 colon cancer cells.

  1989cited by this paper
• 5' flanking sequence and structure of a gene encoding rat 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase.

  1989cited by this paper
• Nucleotide sequence of the maltotetraohydrolase gene from Pseudomonas saccharophila

  1989cited by this paper
• Fructose 2,6-bisphosphate and insulin stimulation of glycolysis in 3T3-L1 adipocytes.

  1989cited by this paper
• Cloning and expression in Escherichia coli of a rat hepatoma cell cDNA coding for 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase.

  1989cited by this paper
• Control of fructose 2,6‐bisphosphate levels in rat macrophages by glucose and phorbol ester

  1989cited by this paper
• Characterization of distinct mRNAs coding for putative isozymes of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase.

  1989cited by this paper
• Hormonal regulation of hepatic gluconeogenesis and glycolysis.

  1988cited by this paper
• Effect of recombinant cytokines on glycolysis and fructose 2,6-bisphosphate in rheumatoid synovial cells in vitro.

  1988cited by this paper
• Rat hepatoma (HTC) cell 6-phosphofructo-2-kinase differs from that in liver and can be separated from fructose-2,6-bisphosphatase.

  1988cited by this paper
• Fos and Jun: the AP-1 connection.

  1988cited by this paper
• Complete amino acid sequence of rat liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase.

  1988cited by this paper
• Phorbol 12,13-dibutyrate and mitogens increase fructose 2,6-bisphosphate in lymphocytes. Comparison of lymphocyte and rat-liver 6-phosphofructo-2-kinase.

  1988cited by this paper
• ACTH stimulates fructose 2,6-bisphosphate synthesis and glycolysis in Y-1 adrenal tumor cells.

  1988cited by this paper
• Isolation of a cDNA clone for rat liver 6-phosphofructo 2-kinase/fructose 2,6-bisphosphatase.

  1987cited by this paper
• Control of phosphofructokinase by fructose 2,6-bisphosphate in B-lymphocytes and B-chronic lymphocytic leukemia cells.

  1987cited by this paper
• Complete nucleotide sequence coding for rat liver 6‐phosphofructo‐2‐kinase/fructose‐2,6‐bisphosphatase derived from a cDNA clone

  1987cited by this paper
• Effect of endotoxin-induced monokines on glucose metabolism in the muscle cell line L6.

  1987cited by this paper
• Role of fructose 2,6-bisphosphate in the control of glycolysis in mammalian tissues.

  1987cited by this paper
• Fructose 2,6-bisphosphate.

  1987cited by this paper
• Adenylate cyclase stimulating agents and mitogens raise fructose 2,6‐bisphosphate levels in human fibroblasts Evidence for a dual control of the metabolite

  1987cited by this paper
• Fructose 2,6‐bisphosphate in isolated foetal hepatocytes

  1987cited by this paper
• Mechanism of thrombin-induced rise in platelet fructose 2,6-bisphosphate content. Studies using phorbol myristate acetate, dioctanoylglycerol and ionophore A23187.

  1987cited by this paper
• Purification and properties of phosphofructokinase 2/fructose 2,6-bisphosphatase from chicken liver and from pigeon muscle.

  1986cited by this paper
• Fructose 2,6-bisphosphate in human platelets: its possible role in the control of basal and thrombin-stimulated glycolysis.

  1986cited by this paper
• Hormonal control of fructose 2,6-bisphosphate concentration in the HT29 human colon adenocarcinoma cell line. Alpha 2-adrenergic agonists counteract effect of vasoactive intestinal peptide.

  1986cited by this paper
• Regulation of fructose 2,6-bisphosphate metabolism in human fibroblasts.

  1986cited by this paper
• Expression of the v-src or v-fps oncogene increases fructose 2,6-bisphosphate in chick-embryo fibroblasts. Novel mechanism for the stimulation of glycolysis by retroviruses.

  1986cited by this paper
• Fructose 2,6-bisphosphate and the control of glycolysis by glucocorticoids and by other agents in rat hepatoma cells.

  1985cited by this paper
• Effect of glutamine on fructose 2,6-bisphosphate and on glucose metabolism in HeLa cells and in chick-embryo fibroblasts.

  1985cited by this paper
• Fructose 2,6-bisphosphate and enzymatic activities for its metabolism in ascites tumor.

  1985cited by this paper
• The effect of insulin on Fru‐2,6‐P2 levels in human fibroblasts

  1984cited by this paper
• Isozyme alterations, gene regulation and the neoplastic transformation.

  1983cited by this paper
• Gluconeogenesis and related aspects of glycolysis.

  1983cited by this paper
• Increase of the glycolytic rate in human resting fibroblasts following serum stimulation

  1983cited by this paper
• Control of liver 6-phosphofructokinase by fructose 2,6-bisphosphate and other effectors.

  1981cited by this paper
• Fructose 2,6-bisphosphate, the probably structure of the glucose- and glucagon-sensitive stimulator of phosphofructokinase.

  1980cited by this paper
• Control of the fructose-6-phosphate/fructose 1,6-bisphosphate cycle in isolated hepatocytes by glucose and glucagon. Role of a low-molecular-weight stimulator of phosphofructokinase.

  1980cited by this paper
• Glycolysis in quiescent cultures of 3T3 cells. Stimulation by serum, epidermal growth factor, and insulin in intact cells and persistence of the stimulation after cell homogenization.

  1978cited by this paper
• The effect of phorbol diesters on chicken embryo fibroblasts.

  1977cited by this paper
• Alterations in glucose metabolism in chick-embryo cells transformed by Rous sarcoma virus: intracellular levels of glycolytic intermediates.

  1974cited by this paper

• Energy Metabolism on Mitochondrial Maturation and Its Effects on Cardiomyocyte Cell Fate

  2022cites this paper
• Chloropupukeananin and Pestalofone C Regulate Autophagy through AMPK and Glycolytic Pathway

  2020cites this paper
• Lactate as a signaling molecule: Journey from dead end product of glycolysis to tumor survival.

  2019cites this paper
• Process development of instant Moringa pod soup powder supplemented with herbs

  2019cites this paper
• Therapeutic targeting of PFKFB3 with a novel glycolytic inhibitor PFK158 promotes lipophagy and chemosensitivity in gynecologic cancers

  2018cites this paper
• PI3K–Akt signaling controls PFKFB3 expression during human T-lymphocyte activation

  2018cites this paper
• Steroid Receptor Coactivator-2 Controls the Pentose Phosphate Pathway through RPIA in Human Endometrial Cancer Cells

  2018cites this paper
• 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase isoform 3 spatially mediates autophagy through the AMPK signaling pathway

  2017cites this paper
• Role of Akt/PKB and PFKFB isoenzymes in the control of glycolysis, cell proliferation and protein synthesis in mitogen-stimulated thymocytes.

  2017cites this paper
• Metabolic Dysregulation in Environmental Carcinogenesis and Toxicology

  2017cites this paper
• Targeting the Seven Cancer Hallmarks by Modulation of Oxidative Stress-induced Inflammation and Immune Activation: A Radical Therapeutic Approach

  2017cites this paper
• p53 coordinates DNA repair with nucleotide synthesis by suppressing PFKFB3 expression and promoting the pentose phosphate pathway

  2016cites this paper
• Akt mediates TIGAR induction in HeLa cells following PFKFB3 inhibition

  2016cites this paper
• PFKFB3 potentially contributes to paclitaxel resistance in breast cancer cells through TLR4 activation by stimulating lactate production.

  2016cites this paper
• Diabetes and risk of cancer

  2015cites this paper
• Steroid receptor coactivators as therapeutic targets in the female reproductive system.

  2015cites this paper
• Metabolic reprogramming and dysregulated metabolism: cause, consequence and/or enabler of environmental carcinogenesis?

  2015cites this paper
• Reprint of "Steroid receptor coactivators as therapeutic targets in the female reproductive system".

  2015cites this paper
• A novel approach to the discovery of anti-tumor pharmaceuticals: searching for activators of liponecrosis

  2015cites this paper
• The metabolic alterations of cancer cells.

  2014cites this paper
• AMPK, signalisation hypoxique et métabolisme tumoral

  2014cites this paper
• The Effects of AraC , Simvastatin and combo therapy on energy metabolism of HL-60 promyolocytic leukemia cell lines

  2013cites this paper
• Characterisation of the interactions and biological impacts of cisplatin analogues and metallo-drug complexes with DNA

  2013cites this paper
• The Effects of Ara-C, Simvastatin and combo therapy on energy metabolism of HL-60 promyolocytic leukemia cell lines

  2013cites this paper
• Genome-based metabolic modelling of CHO cells

  2013cites this paper
• Insights into the catalytic mechanisms of the protein enzymes, PFKFB3 and VldE, using x-ray crystallography

  2012cites this paper
• Structure-Based Development of Small Molecule PFKFB3 Inhibitors: A Framework for Potential Cancer Therapeutic Agents Targeting the Warburg Effect

  2011cites this paper
• The Warburg and Crabtree effects: On the origin of cancer cell energy metabolism and of yeast glucose repression.

  2011cites this paper
• Block Copolymer Micelles for Controlled Delivery of Glycolytic Enzyme Inhibitors

  2011cites this paper
• Fructose 2,6-bisphosphate: the last milestone of the 20th century in metabolic control?

  2010cites this paper
• The PFKFB3 splice variant UBI2K4 is downregulated in high‐grade astrocytomas and impedes the growth of U87 glioblastoma cells

  2009cites this paper
• Regulation of glucose metabolism by 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatases in cancer.

  2009cites this paper
• Nuclear Targeting of 6-Phosphofructo-2-kinase (PFKFB3) Increases Proliferation via Cyclin-dependent Kinases*

  2009cites this paper
• The effect of glucose on cardiac AMP-activated protein kinase

  2009cites this paper
• Sobre expresión de genes de las enzimas de la vía glicolítica en células cancerígenas

  2007cites this paper
• Hypoxia, glucose metabolism and the Warburg’s effect

  2007cites this paper
• The unfolded protein response and cancer: a brighter future unfolding?

  2007cites this paper
• Caracterització i regulació transcripcional del gen "pfkfb3"

  2007cites this paper
• Ras transformation requires metabolic control by 6-phosphofructo-2-kinase

  2006cites this paper
• Mitocans: mitochondrial targeted anti-cancer drugs as improved therapies and related patent documents.

  2006cites this paper
• PFKFB3 gene silencing decreases glycolysis, induces cell‐cycle delay and inhibits anchorage‐independent growth in HeLa cells

  2006cites this paper
• Dynamics of the Cellular Metabolome during Human Cytomegalovirus Infection

  2006cites this paper
• 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase and tumor cell glycolysis

  2006cites this paper
• Targeted disruption of inducible 6-phosphofructo-2-kinase results in embryonic lethality.

  2005cites this paper
• Phosphorylation of the 6-Phosphofructo-2-Kinase/Fructose 2,6-Bisphosphatase/PFKFB3 Family of Glycolytic Regulators in Human Cancer

  2005cites this paper
• in Human Cancer 2 , 6-Bisphosphatase / PFKFB 3 Family of Glycolytic Regulators Phosphorylation of the 6-Phosphofructo-2-Kinase / Fructose Updated

  2005cites this paper
• Expression of inducible 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase/PFKFB3 isoforms in adipocytes and their potential role in glycolytic regulation.

  2005cites this paper
• The kinase activity of human brain 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase is regulated via inhibition by phosphoenolpyruvate.

  2005cites this paper
• 6-Phosphofructo-2-kinase (pfkfb3) Gene Promoter Contains Hypoxia-inducible Factor-1 Binding Sites Necessary for Transactivation in Response to Hypoxia*

  2004cites this paper
• Response to Treatment: A Balance Between Glycolysis and Physical Constraints

  2004cites this paper
• High expression of inducible 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (iPFK-2; PFKFB3) in human cancers.

  2002influential citation
• Aminolaevulinic acid-induced photodynamic therapy: cellular responses to glucose starvation

  2002cites this paper
• Hypoxia-inducible Factor-1-mediated Expression of the 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 (PFKFB3) Gene

  2002cites this paper
• Insulin induces PFKFB3 gene expression in HT29 human colon adenocarcinoma cells.

  2002cites this paper
• Signal transduction dynamics of the protein kinase-A/phosphofructokinase-2 system in Saccharomyces cerevisiae.

  2001cites this paper
• Overexpression of fructose 2,6-bisphosphatase decreases glycolysis and delays cell cycle progression.

  2000influential citation
• Identification of the promoter region of human placental 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene.

  2000cites this paper
• The proinflammatory mediator macrophage migration inhibitory factor induces glucose catabolism in muscle.

  2000cites this paper
• Effects of overexpression of the liver subunit of 6-phosphofructo-1-kinase on the metabolism of a cultured mammalian cell line.

  2000cites this paper
• Outer mitochondrial membrane permeability can regulate coupled respiration and cell survival.

  2000cites this paper
• Cells overexpressing fructose‐2,6‐bisphosphatase showed enhanced pentose phosphate pathway flux and resistance to oxidative stress

  2000cites this paper
• Elevated Levels of Hepatocyte Nuclear Factor 3β in Mouse Hepatocytes Influence Expression of Genes Involved in Bile Acid and Glucose Homeostasis

  2000cites this paper
• Regulation of prostate cancer cell division by glucose

  1999cites this paper
• An inducible gene product for 6-phosphofructo-2-kinase with an AU-rich instability element: role in tumor cell glycolysis and the Warburg effect.

  1999cites this paper
• Apoptosis induced by growth factor withdrawal in fibroblasts overproducing fructose 2,6‐bisphosphate

  1999cites this paper
• Impaired glycolysis and protein catabolism induced by acid in L6 rat muscle cells

  1998cites this paper
• Bioenergetics of rat prostate cancer cell migration

  1998cites this paper
• Induction of erythroid differentiation is associated with inhibition of glycolysis and a decrease in fructose 2,6-bisphosphate levels.

  1997cites this paper
• Stoffwechsel der Kohlenhydrate

  1997cites this paper
• Identification of PRG1, a novel progestin-responsive gene with sequence homology to 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase.

  1997cites this paper
• Association of Phosphofructokinase-M with Caveolin-3 in Differentiated Skeletal Myotubes

  1997cites this paper
• Hepatocyte growth factor and transforming growth factor beta regulate 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene expression in rat hepatocyte primary cultures.

  1996cites this paper
• Uncharged tRNA-phosphofructokinase interaction in amino acid deficiency

  1996cites this paper
• Fructose 2,6-bisphosphate metabolism during megakaryocytic differentiation of K562 and MEG-01 cells

  1996cites this paper
• The 50-kDa glucose 6-phosphate-sensitive hexokinase of Schistosoma mansoni.

  1994cites this paper
• A qualitative and quantitative protein database approach identifies individual and groups of functionally related proteins that are differentially regulated in simian virus 40 (SV40) transformed human keratinocytes: An overview of the functional changes associated with the transformed phenotype

  1994cites this paper
• Characterization of a hepatoma mRNA transcribed from a third promoter of a 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-encoding gene and controlled by ets oncogene-related products.

  1993cites this paper