The yeast Hsp70 Ssa1 is a sensor for activation of the heat shock response by thiol-reactive compounds

Diverse thiol-reactive compounds are found to activate the Hsf1-regulated heat shock response in Saccharomyces cerevisiae. The highly conserved cytosolic Hsp70 protein chaperone is shown to act as a sensor for these molecules through a pair of reactive cysteine residues in the nucleotide-binding domain.

• Publication year

  2012

• Venue

  Molecular Biology of the Cell

• Publication date

  2012-09-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1091/mbc.E12-06-0447PMID 22809627PMCID 3469052
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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