Uncoupling protein-2 knockdown mediates the cytotoxic effects of cisplatin.

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Free Radical Biology & Medicine

• Publication date

  2010-08-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.freeradbiomed.2010.05.031PMID 20595066
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Structural and biochemical changes in mitochondria after cisplatin treatment of Dalton's lymphoma-bearing mice.

  2010cited by this paper
• Mitochondria-targeted disruptors and inhibitors of cytochrome c/cardiolipin peroxidase complexes: a new strategy in anti-apoptotic drug discovery.

  2009cited by this paper
• Hydrogen Peroxide Regulates the Mitochondrial Content of Uncoupling Protein 5 in Colon Cancer Cells

  2009cited by this paper
• The mitochondrial uncoupling protein-2 promotes chemoresistance in cancer cells.

  2008cited by this paper
• Differences in Mitochondrial Function and Antioxidant Systems between Regions of Human Glioma

  2008cited by this paper
• Arsenic induced mitochondrial DNA damage and altered mitochondrial oxidative function: implications for genotoxic mechanisms in mammalian cells.

  2007cited by this paper
• Age-related macular degeneration and retinal protein modification by 4-hydroxy-2-nonenal.

  2007cited by this paper
• Alteration of mitochondrial function and cell sensitization to death

  2007cited by this paper
• Genipin inhibits UCP2-mediated proton leak and acutely reverses obesity- and high glucose-induced beta cell dysfunction in isolated pancreatic islets.

  2006cited by this paper
• The Emerging Functions of UCP2 in Health, Disease, and Therapeutics

  2006cited by this paper
• Role of mitochondrial DNA in toxic responses to oxidative stress.

  2006cited by this paper
• Cisplatin Preferentially Binds Mitochondrial DNA and Voltage-Dependent Anion Channel Protein in the Mitochondrial Membrane of Head and Neck Squamous Cell Carcinoma: Possible Role in Apoptosis

  2006cited by this paper
• Vitamin C antagonizes the cytotoxic effects of antineoplastic drugs.

  2005cited by this paper
• Physiological functions of the mitochondrial uncoupling proteins UCP2 and UCP3.

  2005cited by this paper
• Role of mitochondria in toxic oxidative stress.

  2005cited by this paper
• Genipin-induced apoptosis in hepatoma cells is mediated by reactive oxygen species/c-Jun NH2-terminal kinase-dependent activation of mitochondrial pathway.

  2005cited by this paper
• Resistance to paclitaxel is proportional to cellular total antioxidant capacity.

  2005cited by this paper
• Platelet mitochondrial evaluation during cytochrome c and dichloroacetate treatments of MELAS.

  2005cited by this paper
• Hydroxynonenal and uncoupling proteins: A model for protection against oxidative damage

  2005cited by this paper
• Increased expression of uncoupling protein 2 in HepG2 cells attenuates oxidative damage and apoptosis

  2005cited by this paper
• Oxidative damage during chagasic cardiomyopathy development: role of mitochondrial oxidant release and inefficient antioxidant defense.

  2004cited by this paper
• Characterization of Superoxide-producing Sites in Isolated Brain Mitochondria*

  2004cited by this paper
• Expression of Uncoupling Protein-2 in Human Colon Cancer

  2004cited by this paper
• Mitochondria as cancer drug targets.

  2004cited by this paper
• Mitochondrial proliferation during apoptosis induced by anticancer agents: effects of doxorubicin and mitoxantrone on cancer and cardiac cells

  2004cited by this paper
• Modulation of mitochondrial membrane potential and reactive oxygen species production by copper in astrocytes

  2003cited by this paper
• Ascorbic acid suppresses drug-induced apoptosis in human colon cancer cells by scavenging mitochondrial superoxide anions.

  2003cited by this paper
• Early changes in intramitochondrial cardiolipin distribution during apoptosis.

  2002cited by this paper
• Mitochondria as a Pharmacological Target

  2002cited by this paper
• Characterization of a novel metabolic strategy used by drug‐resistant tumor cells

  2002cited by this paper
• Rapid determination of glutathione peroxidase and thioredoxin reductase activities using a 96-well microplate format: comparison to standard cuvette-based assays.

  2001cited by this paper
• Mitochondrion as a novel target of anticancer chemotherapy.

  2000cited by this paper
• Mitochondria in the Programmed Death Phenomena; A Principle of Biology: “It Is Better to Die than to be Wrong”

  2000cited by this paper
• Increase of mitochondria and mitochondrial DNA in response to oxidative stress in human cells.

  2000cited by this paper
• Rapid microplate assay for superoxide scavenging efficiency.

  2000cited by this paper
• Mitochondrial control of apoptosis: an overview.

  1999cited by this paper
• “Mild” Uncoupling of Mitochondria

  1997cited by this paper
• Phase I trial of buthionine sulfoximine in combination with melphalan in patients with cancer.

  1996cited by this paper
• Buthionine sulfoximine pretreatment potentiates the effect of isolated lung perfusion with doxorubicin.

  1995cited by this paper
• Glutathione peroxidase compensates for the hypersensitivity of Cu,Zn-superoxide dismutase overproducers to oxidant stress.

  1994cited by this paper
• A microtiter plate assay for cytochrome c oxidase in permeabilized whole cells.

  1993cited by this paper
• 10N-nonyl acridine orange interacts with cardiolipin and allows the quantification of this phospholipid in isolated mitochondria.

  1992cited by this paper
• Automated assays for superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase activity.

  1990cited by this paper
• Influence of cis-diamminedichloroplatinum(II) on DNA synthesis and cell cycle progression in excision repair proficient and deficient Chinese hamster ovary cells.

  1988cited by this paper
• A spectrophotometric method for determination of catalase activity in small tissue samples.

  1988cited by this paper
• Comparative pharmacokinetics of cisplatin and three analogues in mice and humans.

  1987cited by this paper
• 5-Fluorouracil concentrations in human plasma following R,S-1-(tetrahydro-2-furanyl)-5-fluorouracil (ftorafur) administration.

  1979cited by this paper
• A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.

  1976cited by this paper
• Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues.

  1969cited by this paper

• Tracking carboplatin chemoresistance in ovarian cancer by scanning electrochemical microscopy

  2025cites this paper
• UCP2 and pancreatic cancer: conscious uncoupling for therapeutic effect

  2024cites this paper
• The transcription factor c-Jun inhibits RBM39 to reprogram pre-mRNA splicing during genotoxic stress

  2022cites this paper
• Revisiting the Anti-Cancer Toxicity of Clinically Approved Platinating Derivatives

  2022cites this paper
• Exploring the therapeutic potential of mitochondrial uncouplers in cancer

  2021cites this paper
• Regression Modeling of the Antioxidant-to-Nephroprotective Relation Shows the Pivotal Role of Oxidative Stress in Cisplatin Nephrotoxicity

  2021cites this paper
• Cardiotoxicity Associated with Chemotherapy Used in Gastrointestinal Tumours

  2021cites this paper
• Genipin enhances the antitumor effect of elesclomol in A549 lung cancer cells by blocking uncoupling protein-2 and stimulating reactive oxygen species production

  2020cites this paper
• Targeting Aurora A Kinase (AAK) in Platinum-Resistant High Grade Serous Ovarian Cancer

  2020cites this paper
• Potential use of n-3 PUFAs to prevent oxidative stress-derived ototoxicity caused by platinum-based chemotherapy.

  2020cites this paper
• Kaempferol attenuated cisplatin-induced cardiac injury via inhibiting STING/NF-κB-mediated inflammation.

  2020cites this paper
• Melatonin Enhances Cisplatin and Radiation Cytotoxicity in Head and Neck Squamous Cell Carcinoma by Stimulating Mitochondrial ROS Generation, Apoptosis, and Autophagy

  2019cites this paper
• Unexpected therapeutic effects of cisplatin.

  2019cites this paper
• Inhibition of PI3K/mTOR increased the sensitivity of hepatocellular carcinoma cells to cisplatin via interference with mitochondrial‐lysosomal crosstalk

  2019cites this paper
• Cereus jamacaru D.C. Hydroalcoholic Extract Promotes Anti-Cytotoxic and Antitumor Activity

  2018cites this paper
• Exposure to Antineoplastic Agents Induces Cytotoxicity in Nurse Lymphocytes: Role of Mitochondrial Damage and Oxidative Stress

  2018cites this paper
• HOXA4/HOXB3 gene expression signature as a biomarker of recurrence in patients with high-grade serous ovarian cancer following primary cytoreductive surgery and first-line adjuvant chemotherapy.

  2018cites this paper
• Different mitochondrial response to cisplatin and hyperthermia treatment in human AGS, Caco-2 and T3M4 cancer cell lines

  2018cites this paper
• Fullerene C60 Penetration into Leukemic Cells and Its Photoinduced Cytotoxic Effects

  2017cites this paper
• Mitochondrial uncoupling in cancer cells: Liabilities and opportunities.

  2017cites this paper
• Efecto de la inhibición de la UCP2 sobre el estrés oxidativo inducido por citotóxicos en líneas de cáncer de mama MCF-7

  2016influential citation
• Importancia de la SIRT3 en el tratamiento del cáncer de mama

  2016cites this paper
• Changes in cellular phenotype and resistance to cisplatin in an oral squamous carcinoma model over-expressing cytoglobin

  2016cites this paper
• Protective effect of riboflavin on cisplatin induced toxicities: a gender-dependent study.

  2015cites this paper
• MiR-214 increases the sensitivity of breast cancer cells to tamoxifen and fulvestrant through inhibition of autophagy

  2015cites this paper
• Overexpression of uncoupling protein-2 in cancer: metabolic and heat changes, inhibition and effects on drug resistance

  2015cites this paper
• Why cancer cells have a more hyperpolarised mitochondrial membrane potential and emergent prospects for therapy

  2015cites this paper
• UCP2 inhibition sensitizes breast cancer cells to therapeutic agents by increasing oxidative stress.

  2015cites this paper
• New mechanisms for old drugs: Insights into DNA-unrelated effects of platinum compounds and drug resistance determinants.

  2015cites this paper
• Improving the Efficacy of Cisplatin in Colon Cancer HT-29 Cells via Combination Therapy with Selenium

  2015cites this paper
• of Pharmacology and Improving the Efficacy of Cisplatin in Colon Cancer HT29 Cells via Combination Therapy with Selenium

  2015cites this paper
• Improving the Efficacy of Cisplatin in Colon Cancer HT-29 Cells via Combination Therapy with Selenium

  2015cites this paper
• Efectos de los estrógenos, la genisteína y la leptina sobre el estrés oxidativo en el cáncer de mama. Importancia de la UCP2

  2014cites this paper
• Angiotensin II type 1 receptor blockers increase tolerance of cells to copper and cisplatin

  2014cites this paper
• Phytoestrogens and mitochondrial biogenesis in breast cancer. Influence of estrogen receptors ratio.

  2014cites this paper
• Oxidative Stress Induced in Nurses by Exposure to Preparation and Handling of Antineoplastic Drugs in Mexican Hospitals: A Multicentric Study

  2014cites this paper
• Cáncer de colon: nuevos hallazgos moleculares y posible importancia clínica Colon cancer: new molecular findings and their potential clinical relevance

  2013cites this paper
• Vitamin B2: A promising adjuvant in cisplatin based chemoradiotherapy by cellular redox management

  2013cites this paper
• Intracellular ion channels and cancer

  2013cites this paper
• Forkhead box protein A1 inhibits the expression of uncoupling protein 2 in hydrogen peroxide-induced A549 cell line

  2013cites this paper
• The oxidative stress in breast tumors of postmenopausal women is ERα/ERβ ratio dependent.

  2013cites this paper
• SERPINB3 protects from oxidative damage by chemotherapeutics through inhibition of mitochondrial respiratory complex I

  2013cites this paper
• Glutathionylation of UCP2 sensitizes drug resistant leukemia cells to chemotherapeutics.

  2013cites this paper
• Cisplatin Induces a Mitochondrial-ROS Response That Contributes to Cytotoxicity Depending on Mitochondrial Redox Status and Bioenergetic Functions

  2013cites this paper
• Subcellular targets of cisplatin cytotoxicity: an integrated view.

  2012cites this paper
• Importancia de los receptores estrogénicos en el estrés oxidativo y el cáncer. Función, biogénesis y dinámica mitocondrial

  2012cites this paper
• The ERalpha/ERbeta ratio determines oxidative stress in breast cancer cell lines in response to 17Beta‐estradiol

  2012cites this paper
• UCP2 Inhibits ROS-Mediated Apoptosis in A549 under Hypoxic Conditions

  2012cites this paper
• Mitochondrial recoupling: a novel therapeutic strategy for cancer?

  2011cites this paper
• Development of chromanes as novel inhibitors of the uncoupling proteins.

  2011cites this paper
• 17β-Estradiol regulates oxidative stress in prostate cancer cell lines according to ERalpha/ERbeta ratio.

  2011cites this paper
• Platinum-Based Compounds and Risk for Cardiovascular Toxicity in the Elderly: Role of the Antioxidants in Chemoprevention

  2011cites this paper
• Genipin-Induced Inhibition of Uncoupling Protein-2 Sensitizes Drug-Resistant Cancer Cells to Cytotoxic Agents

  2010cites this paper