Human mesothelioma cells exhibit tumor cell–specific differences in phosphatidylinositol 3-kinase/AKT activity that predict the efficacy of Onconase

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Molecular Cancer Therapeutics

• Publication date

  2005-05-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1158/1535-7163.MCT-04-0243PMID 15897248
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The pathogenesis of mesothelioma.

  2006cited by this paper
• Pathogenesis of malignant mesothelioma.

  2004cited by this paper
• Src-dependent ERK5 and Src/EGFR-dependent ERK1/2 activation is required for cell proliferation by asbestos

  2004cited by this paper
• Multimodality therapy in mesothelioma: role of chemotherapy.

  2004cited by this paper
• Simian Virus 40 Infection Down-Regulates the Expression of Nitric Oxide Synthase in Human Mesothelial Cells

  2004cited by this paper
• Malignant pleural mesothelioma: update, current management, and newer therapeutic strategies.

  2004influential reference
• Integration of multimodality approaches in the management of malignant pleural mesothelioma.

  2004cited by this paper
• Activation of P2Y2 receptor induces c‐FOS protein through a pathway involving mitogen‐activated protein kinases and phosphoinositide 3‐kinases in HeLa cells

  2003cited by this paper
• New developments about the association of SV40 with human mesothelioma

  2003cited by this paper
• PTEN: The down side of PI 3-kinase signalling.

  2002cited by this paper
• The phosphatidylinositol 3-Kinase–AKT pathway in human cancer

  2002cited by this paper
• Association of SV40 with human tumors

  2002cited by this paper
• Human Cytomegalovirus Major Immediate-Early Proteins and Simian Virus 40 Large T Antigen Can Inhibit Apoptosis through Activation of the Phosphatidylinositide 3′-OH Kinase Pathway and the Cellular Kinase Akt

  2002cited by this paper
• The phosphoinositide 3-kinase pathway.

  2002cited by this paper
• The pathogenesis of mesothelioma.

  2002cited by this paper
• Phase II trial of a single weekly intravenous dose of ranpirnase in patients with unresectable malignant mesothelioma.

  2002cited by this paper
• SV40 replication in human mesothelial cells induces HGF/Met receptor activation: A model for viral-related carcinogenesis of human malignant mesothelioma

  2001cited by this paper
• Cancer chemotherapy--ribonucleases to the rescue.

  2001cited by this paper
• Anti-apoptotic signaling by hepatocyte growth factor/Met via the phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase pathways.

  2001cited by this paper
• Ten years of protein kinase B signalling: a hard Akt to follow.

  2001cited by this paper
• Molecular determinants of apoptosis induced by the cytotoxic ribonuclease onconase: evidence for cytotoxic mechanisms different from inhibition of protein synthesis.

  2000cited by this paper
• New molecular and epidemiological issues in mesothelioma: Role of SV40

  1999cited by this paper
• Cell cycle-related differences in susceptibility of NIH/3T3 cells to ribonucleases.

  1999cited by this paper
• Human mesotheliomas contain the simian virus-40 regulatory region and large tumor antigen DNA sequences.

  1998cited by this paper
• Novel cell imaging techniques show induction of apoptosis and proliferation in mesothelial cells by asbestos.

  1997cited by this paper
• Apoptosis is observed in mesothelial cells after exposure to crocidolite asbestos.

  1996cited by this paper
• The epidemiology of mesothelioma in historical context.

  1996cited by this paper
• Asbestos: scientific developments and implications for public policy.

  1990cited by this paper
• Asbestos-related diseases.

  1989cited by this paper

• Strengths and Challenges of Secretory Ribonucleases as AntiTumor Agents

  2021cites this paper
• The pathogenesis of mesothelioma is driven by a dysregulated translatome

  2021cites this paper
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  2020cites this paper
• The prognostic analysis of the some clinicopathological parameters and gene protein expressions in malignant mesothelioma.

  2019cites this paper
• Cell Signaling and Epigenetic Mechanisms in Mesothelioma

  2017cites this paper
• RC-6 ribonuclease induces caspase activation, cellular senescence and neuron-like morphology in NT2 embryonal carcinoma cells.

  2014cites this paper
• Cell targets of antitumor ribonucleases

  2014cites this paper
• The role of key genes and pathways involved in the tumorigenesis of Malignant Mesothelioma.

  2014cites this paper
• Overview of the biochemical and genetic processes in malignant mesothelioma*

  2014cites this paper
• Current issues in malignant pleural mesothelioma evaluation and management.

  2014cites this paper
• [Cellular targets of antitumor ribonucleases].

  2014cites this paper
• New insights into understanding the mechanisms, pathogenesis, and management of malignant mesotheliomas.

  2013cites this paper
• Exploiting RNA as a new biomolecular target for synthetic polyamines.

  2013cites this paper
• The significance of the EGFR pathway in malignant pleural mesothelioma

  2012cites this paper
• Molecular Basis of Pulmonary Disease

  2012cites this paper
• An extracellular signal-regulated kinase 2 survival pathway mediates resistance of human mesothelioma cells to asbestos-induced injury.

  2011cites this paper
• Carbon nanotubes and pleural damage: perspectives of nanosafety in the light of asbestos experience.

  2011cites this paper
• Ranpirnase Interferes with NF-κB Pathway and MMP9 Activity, Inhibiting Malignant Mesothelioma Cell Invasiveness and Xenograft Growth.

  2011cites this paper
• Asbestos, lung cancers, and mesotheliomas: from molecular approaches to targeting tumor survival pathways.

  2010cites this paper
• Onconase responsive genes in human mesothelioma cells: implications for an RNA damaging therapeutic agent

  2010influential citation
• [Onconase: a ribonuclease with antitumor activity].

  2010cites this paper
• SV40-induced expression of calretinin protects mesothelial cells from asbestos cytotoxicity and may be a key factor contributing to mesothelioma pathogenesis.

  2009cites this paper
• Malignant pleural mesothelioma cells resist anoikis as quiescent pluricellular aggregates

  2009cites this paper
• Future developments in the management of malignant pleural mesothelioma

  2009cites this paper
• Recombinant erythropoietin differently affects proliferation of mesothelioma cells but not sensitivity to cisplatin and pemetrexed

  2008cites this paper
• A novel combination: ranpirnase and rosiglitazone induce a synergistic apoptotic effect by down-regulating Fra-1 and Survivin in cancer cells

  2008cites this paper
• Ranpirnase as a potential antitumor ribonuclease treatment for mesothelioma and other malignancies.

  2008cites this paper
• Ranpirnase and its potential for the treatment of unresectable malignant mesothelioma

  2008cites this paper
• Targeting the MEK1 cascade in lung epithelium inhibits proliferation and fibrogenesis by asbestos.

  2008cites this paper
• Advances in the systemic therapy of malignant pleural mesothelioma

  2008cites this paper
• Molecular targets and targeted therapies for malignant mesothelioma.

  2008cites this paper
• Ranpirnase (Onconase), a cytotoxic amphibian ribonuclease, manipulates tumour physiological parameters as a selective killer and a potential enhancer for chemotherapy and radiation in cancer therapy.

  2008cites this paper
• Environmental Agents in Lung and Pleural Neoplasms

  2008cites this paper
• Ranpirnase (Onconase®), a cytotoxic amphibian ribonuclease, manipulates tumour physiological parameters as a selective killer and a potential enhancer for chemotherapy and radiation in cancer therapy

  2008cites this paper
• The therapeutic potential of the novel ribonuclease ranpirnase (Onconase®) in the treatment of malignant mesothelioma

  2008cites this paper
• RNase-induced apoptosis: fate of calcium-activated potassium channels.

  2008cites this paper
• EGFR and PDGFR differentially promote growth in malignant epithelioid mesothelioma of short and long term survivors

  2007cites this paper
• Fra-1 governs cell migration via modulation of CD44 expression in human mesotheliomas

  2007cites this paper
• SV40 oncoproteins enhance asbestos-induced DNA double-strand breaks and abrogate senescence in murine mesothelial cells.

  2007cites this paper
• A mesothelioma epidemic in Cappadocia: scientific developments and unexpected social outcomes

  2007cites this paper
• [Binase possesses a selective cytotoxic action on kit-transformed precursors of myeloid cells].

  2007cites this paper
• Onconase induces caspase-independent cell death in chemoresistant neuroblastoma cells.

  2007cites this paper
• Unique uptake of acid-prepared mesoporous spheres by lung epithelial and mesothelioma cells.

  2007cites this paper
• Expression of Cancer-Associated Molecules in Malignant Mesothelioma

  2007cites this paper
• GPCRs IN CANCER The functions and therapeutic value of G-protein-coupled receptors Social and personal aspects of cancer research The mesothelioma epidemic in Turkey CANCER

  2007cites this paper
• Biology and management of malignant pleural mesothelioma.

  2006cites this paper
• Ranpirnase – an antitumour ribonuclease: its potential role in malignant mesothelioma

  2006cites this paper
• Cellular and molecular parameters of mesothelioma

  2006cites this paper
• A novel in vitro model of human mesothelioma for studying tumor biology and apoptotic resistance.

  2005cites this paper