Sex specificity of kidney markers to assess prognosis in cirrhotic patients with TIPS

M. Torner,Adjmal Mangal,H. Scharnagl,C. Jansen,M. Praktiknjo,A. Queck,W. Gu,R. Schierwagen,J. Lehmann,F. Uschner,Christiana Graf,C. Strassburg,Javier Fernández,T. Stojaković,R. Woitas,J. Trebicka

Published 2019 in Liver international (Print)

ABSTRACT

Renal function assessed by creatinine is a key prognostic factor in cirrhotic patients. However, creatinine is influenced by several factors, rendering interpretation difficult in some situations. This is especially important in early stages of renal dysfunction where renal impairment might not be accompanied by an increase in creatinine. Other parameters, such as cystatin C (CysC) and beta‐trace protein (BTP), have been evaluated to fill this gap. However, none of these studies have considered the role of the patient's sex. The present study analysed CysC and BTP to evaluate their prognostic value and differentiate them according to sex.

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