Asperegillusawamori Attenuates Colon Inflammation in Ulcerative Colitis in Rats .

Inflammatory bowel diseases (IBD), is a chronic idiopathic inflammatory condition affecting gastrointestinal tract that includes ulcerative colitis (UC) and Crohn’s disease (CD) and resulted in many hazards for patients. Aspergillus awamori is a fungus that has long been used for food processing earlier and has been reported that Aspergillus provides beneficial effects on a host’s health by affecting the host’s intestinal microflora especially on a reduction in the risk of gastrointestinal disease. Therefore, identifying new antioxidants, such as A. awamori, for UC treatment has recently attracted much attention worldwide. Thus, we aimed to investigate the potential alleviating effects of AsperegillusAwamori(AS. Awamori)on acetic acid‐induced ulcerative colitis in rats. Post-treatment withAsperegillusAwamori (50 mg/kg b.w.) attenuated the severity of colitis as evidenced by decrease macroscopic damage, histopathological findings and leukocyte migration. ASP. Awamorialso suppressed the inflammatory response via attenuation of tumornecrosis factor-α (TNF-α), IL-Iβ and also via inhibition of oxidative stress as suppression of lipid peroxides and nitric oxide (NO), superoxide dismutase (SOD) and glutathione peroxidase (GPx). These findings highlight the beneficial effects of AS. Awamoriin IBDtreatment via its role in modulation of colonic inflammation, and oxidative stress.

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