eIF2α phosphorylation and the regulation of translation

No abstract is available for this paper.

• Publication year

  2019

• Venue

  Current Genetics

• Publication date

  2019-09-04

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/s00294-019-01026-1PMID 31485739
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• M(en)TORship lessons on life and death by the integrated stress response.

  2019cited by this paper
• Phosphorylation of the Ribosomal Protein RPL12/uL11 Affects Translation during Mitosis.

  2018cited by this paper
• Neuronal Regulation of eIF2α Function in Health and Neurological Disorders.

  2018cited by this paper
• Regulation of global translation during the cell cycle

  2018cited by this paper
• Translational control

  2018cited by this paper
• Feedback regulation of ribosome assembly

  2018cited by this paper
• Translational control of lipogenic enzymes in the cell cycle of synchronous, growing yeast cells

  2017cited by this paper
• Survival of the drowsiest: the hibernating 100S ribosome in bacterial stress management

  2017cited by this paper
• Regulation of mRNA Translation in Neurons-A Matter of Life and Death.

  2017cited by this paper
• Kinases of eIF2a Switch Translation of mRNA Subset during Neuronal Plasticity

  2017cited by this paper
• The integrated stress response

  2016cited by this paper
• Structural Basis for the Recognition of Eukaryotic Elongation Factor 2 Kinase by Calmodulin.

  2016cited by this paper
• Translational control by 5′-untranslated regions of eukaryotic mRNAs

  2016cited by this paper
• Translational control by eIF2α in neurons: Beyond the stress response

  2016cited by this paper
• CDK1 substitutes for mTOR kinase to activate mitotic cap-dependent protein translation

  2015cited by this paper
• Mitotic 4E-BP1 hyperphosphorylation and cap-dependent translation

  2015cited by this paper
• Translate to divide: сontrol of the cell cycle by protein synthesis

  2015cited by this paper
• Translational Upregulation of an Individual p21Cip1 Transcript Variant by GCN2 Regulates Cell Proliferation and Survival under Nutrient Stress

  2015cited by this paper
• Regulation of mRNA translation during mitosis

  2015cited by this paper
• Stress-induced inhibition of translation independently of eIF2α phosphorylation

  2015cited by this paper
• Signaling through alternative Integrated Stress Response pathways compensates for GCN2 loss in a mouse model of soft tissue sarcoma

  2015cited by this paper
• Ribosomal stress activates eEF2K–eEF2 pathway causing translation elongation inhibition and recruitment of Terminal Oligopyrimidine (TOP) mRNAs on polysomes

  2014cited by this paper
• Eukaryotic elongation factor 2 kinase, an unusual enzyme with multiple roles.

  2014cited by this paper
• The Molecular Mechanism of Eukaryotic Elongation Factor 2 Kinase Activation*

  2014cited by this paper
• The Munc18-1 domain 3a loop is essential for neuroexocytosis but not for syntaxin-1A transport to the plasma membrane

  2013cited by this paper
• New roles of the fission yeast eIF2&agr; kinases Hri1 and Gcn2 in response to nutritional stress

  2013cited by this paper
• The translational landscape of the mammalian cell cycle.

  2013cited by this paper
• ER stress-mediated autophagy promotes Myc-dependent transformation and tumor growth.

  2012cited by this paper
• Characterization of hibernating ribosomes in mammalian cells

  2011cited by this paper
• The mechanism of eukaryotic translation initiation and principles of its regulation

  2010cited by this paper
• Regulation of G1 Arrest and Apoptosis in Hypoxia by PERK and GCN2-Mediated eIF2α Phosphorylation

  2010cited by this paper
• Regulation of G(1) arrest and apoptosis in hypoxia by PERK and GCN2-mediated eIF2alpha phosphorylation.

  2010cited by this paper
• Regulation of translation initiation in eukaryotes: mechanisms and biological targets.

  2009cited by this paper
• The G1-S checkpoint in fission yeast is not a general DNA damage checkpoint

  2008cited by this paper
• Regulation of mRNA Translation during cellular division

  2008cited by this paper
• Transcription elongation by RNA polymerase I is linked to efficient rRNA processing and ribosome assembly.

  2007cited by this paper
• A novel checkpoint mechanism regulating the G1/S transition.

  2007cited by this paper
• Global Translational Responses to Oxidative Stress Impact upon Multiple Levels of Protein Synthesis*

  2006cited by this paper
• Anti-oncogenic role of the endoplasmic reticulum differentially activated by mutations in the MAPK pathway

  2006cited by this paper
• The transcriptional activity of RNA polymerase I is a key determinant for the level of all ribosome components.

  2006cited by this paper
• Translational control in stress and apoptosis

  2005cited by this paper
• PERK and GCN2 contribute to eIF2alpha phosphorylation and cell cycle arrest after activation of the unfolded protein response pathway.

  2005cited by this paper
• Translation reinitiation at alternative open reading frames regulates gene expression in an integrated stress response

  2004cited by this paper
• Stress‐induced gene expression requires programmed recovery from translational repression

  2003cited by this paper
• Starting the protein synthesis machine: eukaryotic translation initiation.

  2003cited by this paper
• An integrated stress response regulates amino acid metabolism and resistance to oxidative stress.

  2003cited by this paper
• Phosphorylation of Eukaryotic Initiation Factor 2 by Heme-Regulated Inhibitor Kinase-Related Protein Kinases in Schizosaccharomyces pombe Is Important for Resistance to Environmental Stresses

  2002cited by this paper
• Gene-specific regulation by general translation factors.

  2002cited by this paper
• Feedback Inhibition of the Unfolded Protein Response by GADD34-Mediated Dephosphorylation of eIF2α

  2001cited by this paper
• Cell-cycle-dependent translational control.

  2001cited by this paper
• Regulated translation initiation controls stress-induced gene expression in mammalian cells.

  2000cited by this paper
• Translational Regulation of Yeast GCN4

  1997cited by this paper
• The eIF‐2α kinases and the control of protein synthesis 1

  1996cited by this paper
• Mammalian eukaryotic initiation factor 2 alpha kinases functionally substitute for GCN2 protein kinase in the GCN4 translational control mechanism of yeast.

  1993cited by this paper
• Synthesis and modification of proteins during the cell cycle of the yeast Saccharomyces cerevisiae

  1979cited by this paper
• Rate of macromolecular synthesis through the cell cycle of the yeast Saccharomyces cerevisiae.

  1978cited by this paper

• The Cap-Independent Translation of Survivin 5′UTR and HIV-1 IRES Sequences Is Inhibited by Oxidative Stress Produced by H. pylori Gamma-Glutamyl Transpeptidase Activity

  2026cites this paper
• Sirt1-eIF2α axis drives pro-inflammatory macrophage activation through ER stress aggravating liver IRI in aged mice.

  2026cites this paper
• The Integrated Stress Response in Cancer: Paradox and Therapeutic Promise

  2026cites this paper
• KHSRP-mediated Decay of Axonally Localized Prenyl-Cdc42 mRNA Slows Nerve Regeneration

  2025cites this paper
• Transcriptomic analysis of the immune response to in vivo gene electrotransfer in colorectal cancer

  2025cites this paper
• Analysis of Endoplasmic Reticulum Stress Proteins in Spermatogenic Cells After Paclitaxel Administration

  2025cites this paper
• Repressing cytokine storm-like response in macrophages by targeting the eIF2α-integrated stress response pathway.

  2025cites this paper
• Eukaryotic initiation factor 3d Regulates Context-Dependent Pain Hypersensitivity Through the Integrated Stress Response

  2025cites this paper
• KHSRP-mediated decay of axonally localized prenyl-Cdc42 mRNA slows nerve regeneration

  2025cites this paper
• Ionizable Coenzyme‐Engineered Lipid/Fiber Microplexes Boost Ribosomal Translation to Improve mRNA Therapy for Degenerative Diseases

  2025cites this paper
• Reference Genes for Expression Analyses by qRT-PCR in Propsilocerus akamusi (Diptera: Chironomidae)

  2025cites this paper
• Hyperacute response proteins synthesized on γ-tubulin-FTO-MARK4 translation microdomains regulate cancer's acute stress response.

  2025cites this paper
• Translational reprogramming under heat stress: a plant’s perspective

  2025cites this paper
• Regulatory links between the circadian clock and stress-induced biomolecular condensates

  2025cites this paper
• A general framework to analyze potential roles of tDRs in mammalian protein synthesis.

  2025cites this paper
• LINE1 and its host: one cell’s junk is another cell’s treasure

  2024cites this paper
• Stress Granules in Atherosclerosis: Insights and Therapeutic Opportunities.

  2024cites this paper
• Non-Canonical STING-PERK Pathway Modulation of Cellular Senescence and Therapeutic Response in Sepsis-Associated Acute Kidney Injury

  2024cites this paper
• The Role of Endoplasmic Reticulum Stress on Reducing Recombinant Protein Production in Mammalian Cells.

  2024cites this paper
• African swine fever virus maintains de novo global cellular protein synthesis and inhibits stress granules formation via dephosphorylating eIF2α.

  2024cites this paper
• Pan-viral propagation blockade by inhibiting host cell PNPT1.

  2024cites this paper
• Maintenance of proteostasis by Drosophila Rer1 is essential for competitive cell survival and Myc-driven overgrowth

  2024cites this paper
• Collective cell migration relies on PPP1R15-mediated regulation of the endoplasmic reticulum stress response.

  2024cites this paper
• Promoting the production of challenging proteins via induced expression in CHO cells and modified cell-free lysates harboring T7 RNA polymerase and mutant eIF2α

  2024cites this paper
• An inner mitochondrial membrane microprotein from the SLC35A4 upstream ORF regulates cellular metabolism.

  2024cites this paper
• Overexpression of carbonyl reductase 1 in ovarian cancer cells suppresses proliferation and activates the eIF2 signaling pathway

  2024cites this paper
• Role of the integrated stress response system (ISR) in neuropsychiatric pathologies of the central nervous system

  2024cites this paper
• The Role of the Integrated Stress Response (ISR) in Neuropsychiatric Disorders

  2024cites this paper
• African swine fever virus enhances viral replication by increasing intracellular reduced glutathione levels, which suppresses stress granule formation

  2024cites this paper
• Dissociation of mitochondrial and ribosomal biogenesis during thallium administration in rat kidney

  2024cites this paper
• Circadian regulation of translation

  2024cites this paper
• CaMKII suppresses proteotoxicity by phosphorylating BAG3 in response to proteasomal dysfunction

  2024cites this paper
• Evidence for ~12-h ultradian gene programs in humans

  2024cites this paper
• Contribution of the yeast bi-chaperone system in the restoration of the RNA helicase Ded1 and translational activity under severe ethanol stress

  2023cites this paper
• Role of Hydrogen Sulfide and Hypoxia in Hepatic Angiogenesis of Portal Hypertension

  2023cites this paper
• Insights into the Molecular Mechanisms of NRF2 in Kidney Injury and Diseases

  2023cites this paper
• Evidence for conservation of primordial ~12-hour ultradian gene programs in humans under free-living conditions

  2023cites this paper
• The GCN2/eIF2αK stress kinase regulates PP1 to ensure mitotic fidelity

  2023cites this paper
• Generation of host-directed and virus-specific antivirals using targeted protein degradation promoted by small molecules and viral RNA mimics.

  2023cites this paper
• Alternative polyadenylation factor CPSF6 regulates temperature compensation of the mammalian circadian clock

  2023cites this paper
• Effect of eIF2α in Neuronal Injury Induced by High Glucose and the Protective Mechanism of Resveratrol

  2023cites this paper
• Liquid-Liquid Phase Separation of TDP-43 and FUS in Physiology and Pathology of Neurodegenerative Diseases

  2022cites this paper
• Exploitation of the ribosomal protein L10 R98S mutation to enhance recombinant protein production in mammalian cells

  2022cites this paper
• Ribosome changes reprogram translation for chemosurvival in G0 leukemic cells

  2022cites this paper
• Novel compound C150 inhibits pancreatic cancer through induction of ER stress and proteosome assembly

  2022cites this paper
• Loss of Rer1 causes proteotoxic stress that drives cell competition and inhibits Myc-driven overgrowth

  2022cites this paper
• Role of Long Non-Coding RNA in Regulating ER Stress Response on the Progression of Diabetic Complications.

  2022cites this paper
• Tibolone Pre-Treatment Ameliorates the Dysregulation of Protein Translation and Transport Generated by Palmitic Acid-Induced Lipotoxicity in Human Astrocytes: A Label-Free MS-Based Proteomics and Network Analysis

  2022cites this paper
• Gallium Nanodroplets are Anti-Inflammatory without Interfering with Iron Homeostasis.

  2022cites this paper
• Post-transcriptional regulation during stress

  2022cites this paper
• Translational Control of COVID-19 and Its Therapeutic Implication

  2022cites this paper
• A link between DNA double‐strand breaks and regulation of global translation

  2022cites this paper
• Codon usage and protein length-dependent feedback from translation elongation regulates translation initiation and elongation speed

  2021cites this paper
• The Type and Source of Reactive Oxygen Species Influences the Outcome of Oxidative Stress in Cultured Cells

  2021cites this paper
• SZB120 Exhibits Immunomodulatory Effects by Targeting eIF2α to Suppress Th17 Cell Differentiation

  2021cites this paper
• An integrative omics approach reveals posttranscriptional mechanisms underlying circadian temperature compensation

  2021cites this paper
• Intracellular Lipid Accumulation and Mitochondrial Dysfunction Accompanies Endoplasmic Reticulum Stress Caused by Loss of the Co-chaperone DNAJC3

  2021cites this paper
• Memory suppressor genes: Modulating acquisition, consolidation, and forgetting.

  2021cites this paper
• ATP-Independent Initiation during Cap-Independent Translation of m6A-Modified mRNA

  2021cites this paper
• Targeted inhibition of mRNA translation initiation factors as a novel therapeutic strategy for mature B-cell neoplasms

  2020cites this paper
• Bioinformatics for differential proteomics data between triple-negative breast cancer and luminal A subtype breast cancer

  2020cites this paper
• Role of the RNA-binding protein La in cancer pathobiology

  2020cites this paper
• Ribosome profiling reveals ribosome stalling on tryptophan codons upon oxidative stress in fission yeast

  2020cites this paper
• Identification of a Novel Interaction Between SMC1 DNA Damage Repair Protein and Escherichia Coli O157: H7 EspF Using Co-Immunoprecipitation Combined With Mass Spectrometry

  2020cites this paper
• Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast

  2020cites this paper
• Cell Fate Control by Translation: mRNA Translation Initiation as a Therapeutic Target for Cancer Development and Stem Cell Fate Control

  2019cites this paper
• Identi�cation of a novel interaction between SMC1 DNA damage repair protein and Escherichia coli O157: H7 EspF using co-immunoprecipitation combined with mass spectrometry

  year unknowncites this paper