Raising serum urate levels in Parkinson disease

The cause of Parkinson disease (PD) remains unknown, but current evidence points to the interplay of aging, environmental factors, genetic predisposition, inflammation, excitotoxicity, mitochondrial dysfunction, and oxidative/nitrosative stress as underlying mechanisms.1 Based on epidemiologic and experimental data,2 uric acid (UA) has emerged as a potential new player in the jigsaw of PD pathophysiology.

• Publication year

  2019

• Venue

  Neurology

• Publication date

  2019-10-01

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1212/WNL.0000000000008191PMID 31484716
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• [Parkinson's disease].

  2022cited by this paper
• Sex differences by design and outcome in the Safety of Urate Elevation in PD (SURE-PD) trial

  2019cited by this paper
• Urate and the risk of Parkinson's disease in men and women.

  2018cited by this paper
• Urate as a Marker of Risk and Progression of Neurodegenerative Disease

  2016cited by this paper
• Uric Acid Therapy Improves Clinical Outcome in Women With Acute Ischemic Stroke

  2015cited by this paper
• Parkinson's disease

  2015cited by this paper
• Allopurinol reduces levels of urate and dopamine but not dopaminergic neurons in a dual pesticide model of Parkinson's disease.

  2014cited by this paper
• Urate: a novel biomarker of Parkinson's disease risk, diagnosis and prognosis.

  2010cited by this paper
• Uric acid in Parkinson's disease

  2008cited by this paper
• Nitric oxide and peroxynitrite in health and disease.

  2007cited by this paper
• Uric acid provides an antioxidant defense in humans against oxidant- and radical-caused aging and cancer: a hypothesis.

  1981cited by this paper

• The microbiome–gut–brain axis in Parkinson disease — from basic research to the clinic

  2022cites this paper