Characterization of the toxic mechanism triggered by Alzheimer's amyloid‐β peptides via p75 neurotrophin receptor in neuronal hybrid cells

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Journal of Neuroscience Research

• Publication date

  2003-09-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/jnr.10703PMID 12929130
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Involvement of c‐Jun N‐terminal kinase in amyloid precursor protein‐mediated neuronal cell death

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• Oxidative Nerve Cell Death in Alzheimers Disease and Stroke: Antioxidants as Neuroprotective Compounds

  2002cited by this paper
• Transient vesicle leakage initiated by a synthetic apoptotic peptide derived from the death domain of neurotrophin receptor, p75NTR.

  2002influential reference
• Neurotoxic mechanisms by Alzheimer's disease-linked N141I mutant presenilin 2.

  2002cited by this paper
• Molecular Mechanisms for Neuronal Cell Death by Alzheimer’s Amyloid Precursor Protein-Relevant Insults

  2002cited by this paper
• Role of p75 Neurotrophin Receptor in the Neurotoxicity by β-amyloid Peptides and Synergistic Effect of Inflammatory Cytokines

  2002cited by this paper
• Death and survival of neuronal cells exposed to Alzheimer's insults

  2002cited by this paper
• Signaling Events in Amyloid β-Peptide-induced Neuronal Death and Insulin-like Growth Factor I Protection*

  2002influential reference
• Neurotoxic mechanisms triggered by Alzheimer's disease‐linked mutant M146L presenilin 1: involvement of NO synthase via a novel pertussis toxin target

  2002cited by this paper
• Detailed Characterization of Neuroprotection by a Rescue Factor Humanin against Various Alzheimer's Disease-Relevant Insults

  2001cited by this paper
• Characterization of a p75NTR Apoptotic Signaling Pathway Using a Novel Cellular Model*

  2001cited by this paper
• β-Amyloid Induces Neuronal Apoptosis Via a Mechanism that Involves the c-Jun N-Terminal Kinase Pathway and the Induction of Fas Ligand

  2001cited by this paper
• β‐Amyloid‐induced neuronal apoptosis requires c‐Jun N‐terminal kinase activation

  2001cited by this paper
• Multiple caspases are involved in beta-amyloid-induced neuronal apoptosis.

  2001cited by this paper
• CEP‐1347/KT‐7515, an inhibitor of SAPK/JNK pathway activation, promotes survival and blocks multiple events associated with Aβ‐induced cortical neuron apoptosis

  2001cited by this paper
• Secreted Abeta does not mediate neurotoxicity by antibody-stimulated amyloid precursor protein.

  2001cited by this paper
• β-Amyloid Peptide-induced Apoptosis Regulated by a Novel Protein Containing a G Protein Activation Module*

  2001cited by this paper
• Mechanisms of neuroprotection by a novel rescue factor humanin from Swedish mutant amyloid precursor protein.

  2001cited by this paper
• A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and Aβ

  2001cited by this paper
• Amyloid β42 Activates a G-Protein-Coupled Chemoattractant Receptor, FPR-Like-1

  2001cited by this paper
• Secreted Aβ Does Not Mediate Neurotoxicity by Antibody-Stimulated Amyloid Precursor Protein

  2001cited by this paper
• Multiple caspases are involved in β‐amyloid‐induced neuronal apoptosis

  2001cited by this paper
• Neurite Outgrowth Induced by Cyclic AMP Can Be Modulated by the α Subunit of Go

  2000cited by this paper
• Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β

  2000cited by this paper
• beta-Amyloid(1-42) binds to alpha7 nicotinic acetylcholine receptor with high affinity. Implications for Alzheimer's disease pathology.

  2000cited by this paper
• Induction and Activation by Zinc of NADPH Oxidase in Cultured Cortical Neurons and Astrocytes

  2000cited by this paper
• Neurotrophin dependence domain

  2000cited by this paper
• Neurite outgrowth induced by cyclic AMP can be modulated by the alpha subunit of Go.

  2000cited by this paper
• Antibody-regulated neurotoxic function of cell-surface beta-amyloid precursor protein.

  2000cited by this paper
• Multiple domains interacting with Gs in the porcine calcitonin receptor.

  2000cited by this paper
• Expression and characterization of the human YWK-II gene, encoding a sperm membrane protein related to the alzheimer betaA4-amyloid precursorprotein.

  2000cited by this paper
• Amyloid beta interacts with the amyloid precursor protein: a potential toxic mechanism in Alzheimer's disease.

  2000cited by this paper
• Amyloid β interacts with the amyloid precursor protein: a potential toxic mechanism in Alzheimer's disease

  2000cited by this paper
• Multiple Mechanisms Underlie Neurotoxicity by Different Types of Alzheimer's Disease Mutations of Amyloid Precursor Protein*

  2000cited by this paper
• Neuronal Apoptosis by Apolipoprotein E4 through Low-Density Lipoprotein Receptor-Related Protein and Heterotrimeric GTPases

  2000cited by this paper
• Neuronal cell apoptosis by a receptor-binding domain peptide of ApoE4, not through low-density lipoprotein receptor-related protein.

  2000cited by this paper
• β-Amyloid1–42 Binds to α7 Nicotinic Acetylcholine Receptor with High Affinity

  2000cited by this paper
• The Amyloid Precursor Protein Interacts with Go Heterotrimeric Protein within a Cell Compartment Specialized in Signal Transduction

  1999cited by this paper
• A comparison of the cytoplasmic domains of the Fas receptor and the p75 neurotrophin receptor

  1999cited by this paper
• NGF induces apoptosis in a human neuroblastoma cell line expressing the neurotrophin receptor p75NTR

  1998influential reference
• An intracellular protein that binds amyloid-beta peptide and mediates neurotoxicity in Alzheimer's disease.

  1997cited by this paper
• The Juxtamembrane, Cytosolic Region of the Epidermal Growth Factor Receptor Is Involved in Association with α-Subunit of Gs*

  1997cited by this paper
• NMR structure of the death domain of the p75 neurotrophin receptor

  1997cited by this paper
• Binding of beta-amyloid to the p75 neurotrophin receptor induces apoptosis. A possible mechanism for Alzheimer's disease.

  1997influential reference
• G protein βγ complex‐mediated apoptosis by familial Alzheimer's disease mutant of APP

  1997cited by this paper
• An intracellular protein that binds amyloid-β peptide and mediates neurotoxicity in Alzheimer's disease

  1997cited by this paper
• Basic FGF attenuates amyloid β-peptide-induced oxidative stress, mitochondrial dysfunction, and impairment of Na+/K+-ATPase activity in hippocampal neurons

  1997cited by this paper
• Amyloid- (cid:98) peptide–Receptor for Advanced Glycation Endproduct interaction elicits neuronal expression of macrophage-colony stimulating factor: A proinflammatory pathway in Alzheimer disease

  1997cited by this paper
• G protein betagamma complex-mediated apoptosis by familial Alzheimer's disease mutant of APP.

  1997cited by this paper
• Insulin-like growth factor I protects and rescues hippocampal neurons against beta-amyloid- and human amylin-induced toxicity.

  1997cited by this paper
• G Protein-Mediated Neuronal DNA Fragmentation Induced by Familial Alzheimer's Disease-Associated Mutants of APP

  1996cited by this paper
• A femtomolar-acting neuroprotective peptide.

  1996cited by this paper
• A region in the cytosolic domain of the epidermal growth factor receptor antithetically regulates the stimulatory and inhibitory guanine nucleotide-binding regulatory proteins of adenylyl cyclase.

  1995cited by this paper
• Activation of a G protein complex by aggregation of beta-1,4-galactosyltransferase on the surface of sperm.

  1995cited by this paper
• Expression of the low-affinity nerve growth factor receptor enhances beta-amyloid peptide toxicity.

  1994cited by this paper
• Alzheimer amyloid protein precursor complexes with brain GTP-binding protein Go

  1993cited by this paper
• Apoptosis is induced by beta-amyloid in cultured central nervous system neurons.

  1993cited by this paper
• Induction of apoptosis by the low-affinity NGF receptor.

  1993cited by this paper
• Detection of G protein-activator regions in M4 subtype muscarinic, cholinergic, and alpha 2-adrenergic receptors based upon characteristics in primary structure.

  1992cited by this paper
• Inhibition of the ω-conotoxin-sensitive calcium current by distinct G proteins

  1992cited by this paper
• Inhibition of the omega-conotoxin-sensitive calcium current by distinct G proteins.

  1992cited by this paper
• Identification of a conserved protein motif in a group of growth factor receptors

  1990cited by this paper
• Distinctive regulation of the functional linkage between the human cation-independent mannose 6-phosphate receptor and GTP-binding proteins by insulin-like growth factor II and mannose 6-phosphate.

  1990cited by this paper
• Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer's disease.

  1989cited by this paper

• Insulin-like growth factor 1 associated research in Alzheimer’s disease: an exploratory trends analysis

  2026cites this paper
• The Nerve Growth Factor Receptor (NGFR/p75NTR): A Major Player in Alzheimer’s Disease

  2023cites this paper
• Mitochondrial DNA variation in Alzheimer’s disease reveals a unique microprotein called SHMOOSE

  2022cites this paper
• Interlacing the relevance of caspase activation in the onset and progression of Alzheimer's Disease.

  2022cites this paper
• Fading memories in aging and neurodegeneration: Is p75 neurotrophin receptor a culprit?

  2022cites this paper
• New insights into the role of fibroblast growth factors in Alzheimer’s disease

  2021cites this paper
• Is there a role for the p75 neurotrophin receptor in mediating degeneration during oxidative stress and after hypoxia?

  2021cites this paper
• Humanin and Alzheimer's disease: The beginning of a new field.

  2021cites this paper
• Humanin

  2020cites this paper
• Neurotrophins and Neurotrophin Receptors

  2020cites this paper
• Current and Emerging Pharmacological Targets for the Treatment of Alzheimer’s Disease

  2019cites this paper
• The Plasma Membrane: A Platform for Intra- and Intercellular Redox Signaling

  2018cites this paper
• Implication of the neurotrophin receptor p75NTR in vascular diseases: beyond the eye

  2017influential citation
• G-Protein-Coupled Inwardly Rectifying Potassium (GIRK) Channel Activation by the p75 Neurotrophin Receptor Is Required for Amyloid β Toxicity

  2017cites this paper
• proBDNF Accelerates Brain Amyloid-β Deposition and Learning and Memory Impairment in APPswePS1dE9 Transgenic Mice

  2017cites this paper
• The Rationale for Insulin Therapy in Alzheimer’s Disease

  2016cites this paper
• Elevation of cortical C26:0 due to the decline of peroxisomal β-oxidation potentiates amyloid β generation and spatial memory deficits via oxidative stress in diabetic rats.

  2016influential citation
• Relationships between diabetes and cognitive impairment.

  2014cites this paper
• The Binding Receptors of Aβ: an Alternative Therapeutic Target for Alzheimer’s Disease

  2014cites this paper
• Glaucoma--diabetes of the brain: a radical hypothesis about its nature and pathogenesis.

  2014cites this paper
• Brain metabolic dysfunction at the core of Alzheimer's disease.

  2014cites this paper
• NGF and APP Interplay: Focus on YENPTY Motif of Amyloid Precursor Protein and Y682 Residue

  2013cites this paper
• Insulin Resistance and Metabolic Failure Underlie Alzheimer Disease

  2013cites this paper
• Genetic polymorphisms of nerve growth factor receptor (NGFR) and the risk of Alzheimer's disease

  2012cites this paper
• MOCA is an integrator of the neuronal death signals that are activated by familial Alzheimer's disease-related mutants of amyloid β precursor protein and presenilins.

  2012cites this paper
• Sortilin is required for toxic action of Aβ oligomers (AβOs): extracellular AβOs trigger apoptosis, and intraneuronal AβOs impair degradation pathways.

  2012cites this paper
• Molecular Mechanisms of Amyloid Oligomers Toxicity

  2012cites this paper
• Brain Insulin Resistance and Deficiency as Therapeutic Targets in Alzheimer's Disease

  2012cites this paper
• Contributions of Brain Insulin Resistance and Deficiency in Amyloid-Related Neurodegeneration in Alzheimer’s Disease

  2012cites this paper
• Therapeutic targets of brain insulin resistance in sporadic Alzheimer's disease.

  2012cites this paper
• Amyloid Hypothesis: Molecular and Cellular Aspects of Toxicity

  2012cites this paper
• Brain Insulin Resistance and Deficiency as Therapeutic Targets in Alzheimer's Disease

  2012cites this paper
• New Small Molecule Drug Discovery for Alzheimer's Disease

  2012cites this paper
• Contributions of brain insulin resistance and deficiency in amyloid-related neurodegeneration in Alzheimer's disease.

  2012cites this paper
• Melanocytes: a window into the nervous system.

  2012cites this paper
• Insulin Resistance, Cognitive Impairment and Neurodegeneration: Roles of Nitrosamine Exposure, Diet and Lifestyles

  2011cites this paper
• Interfering effect and mechanism of neuregulin on experimental dementia model in rats.

  2011cites this paper
• Pharmacology of the intracellular pathways activated by amyloid beta protein.

  2009cites this paper
• Humanin inhibits neuronal cell death by interacting with a cytokine receptor complex or complexes involving CNTF receptor alpha/WSX-1/gp130.

  2009cites this paper
• NOX Enzymes in the Central Nervous System: From Signaling to Disease

  2009cites this paper
• Amyloid-beta precursor protein mediates neuronal toxicity of amyloid beta through Go protein activation.

  2009cites this paper
• Proteome of synaptosome‐associated proteins in spinal cord dorsal horn after peripheral nerve injury

  2009cites this paper
• Amyloid-precursor protein mediates neuronal toxicity of amyloid through Go protein activation

  2009cites this paper
• Alzheimer's Disease is Type 3 Diabetes—Evidence Reviewed

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• ANALISI FUNZIONALE DEI RECETTORI PER LE NEUROTROFINE p75NTR E Trka IN NEUROBLASTOMA

  2008cites this paper
• p75NTR Antagonistic Cyclic Peptide Decreases the Size of β Amyloid-Induced Brain Inflammation

  2008cites this paper
• A possible physiological role of Abeta as a crosslinker

  2008cites this paper
• Neurotrophic factors in Alzheimer’s disease: role of axonal transport

  2008cites this paper
• Neuroprotection Against Neurodegenerative Diseases: Development of a Novel Hybrid Neuroprotective Peptide Colivelin

  2008cites this paper
• The role of neurotrophins during early development.

  2008cites this paper
• Differences in Extracellular Matrix Production and Basic Fibroblast Growth Factor Response in Skin Fibroblasts from Sporadic and Familial Alzheimer’s Disease

  2007cites this paper
• A cyclic peptide that binds p75NTR protects neurones from beta amyloid (1–40)‐induced cell death

  2007cites this paper
• M‐calpain‐mediated cleavage of GAP‐43 near Ser41 is negatively regulated by protein kinase C, calmodulin and calpain‐inhibiting fragment GAP‐43‐3

  2007cites this paper
• A cell‐biological model of p75NTR signaling

  2007cites this paper
• A ganglioside-induced toxic soluble Abeta assembly. Its enhanced formation from Abeta bearing the Arctic mutation.

  2007cites this paper
• Amyloid Toxicity, Synaptic Dysfunction, and the Biochemistry of Neurodegeneration in Alzheimer’s Disease

  2007cites this paper
• Neurotrophin Signaling and Cell Survival

  2007cites this paper
• A Ganglioside-induced Toxic Soluble Aβ Assembly

  2007cites this paper
• Neuroprotection against neurodegenerative diseases

  2007cites this paper
• Characterization of the signaling pathway downstream p75 neurotrophin receptor involved in β-amyloid peptide-dependent cell death

  2007influential citation
• Transforming growth factor β2 autocrinally mediates neuronal cell death induced by amyloid‐β

  2006cites this paper
• Pro-NGF from Alzheimer's disease and normal human brain displays distinctive abilities to induce processing and nuclear translocation of intracellular domain of p75NTR and apoptosis.

  2006cites this paper
• Beta-amyloid peptides induces neuronal apoptosis via a mechanism independent of unfolded protein responses

  2006cites this paper
• Intracerebral streptozotocin model of type 3 diabetes: Relevance to sporadic Alzheimer's disease

  2006cites this paper
• Molecular indices of oxidative stress and mitochondrial dysfunction occur early and often progress with severity of Alzheimer's disease

  2006cites this paper
• A key role for the microglial NADPH oxidase in APP-dependent killing of neurons.

  2006cites this paper
• Humanin and colivelin: neuronal-death-suppressing peptides for Alzheimer's disease and amyotrophic lateral sclerosis.

  2006cites this paper
• Transforming growth factor beta2 autocrinally mediates neuronal cell death induced by amyloid-beta.

  2006cites this paper
• Nerve Growth Factor, Neural Stem Cells and Alzheimer’s Disease

  2006cites this paper
• Does the p75 neurotrophin receptor mediate Aβ‐induced toxicity in Alzheimer's disease?

  2006influential citation
• Polypeptide and Protein Aggregates with Neurotoxic Properties in Neurodegenerative Disorders: Emphasis on β-Amyloid-Induced Dysfunction of Receptor-Mediated Signal Transduction Pathways

  2006cites this paper
• Alzheimer's disease--an interactive perspective.

  2006cites this paper
• Pro-NGF isolated from the human brain affected by Alzheimer's disease induces neuronal apoptosis mediated by p75NTR.

  2005cites this paper
• Insulin and insulin-like growth factor expression and function deteriorate with progression of Alzheimer's disease: Link to brain reductions in acetylcholine

  2005cites this paper
• Review of insulin and insulin-like growth factor expression, signaling, and malfunction in the central nervous system: Relevance to Alzheimer's disease

  2005cites this paper
• Nerve growth factor and acetyl‐L‐carnitine evoked shifts in acetyl‐CoA and cholinergic SN56 cell vulnerability to neurotoxic inputs

  2005cites this paper
• Neuroprotective effects of anti-aging oriental medicine Lycium barbarum against beta-amyloid peptide neurotoxicity.

  2005cites this paper
• Involvement of tyrosine kinases and STAT3 in Humanin-mediated neuroprotection.

  2005cites this paper
• Low concentrations of aggregated β-amyloid induce neurite formation via the neurotrophin receptor p75

  2005cites this paper
• 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside (AICAR) attenuates the expression of LPS- and Aβ peptide-induced inflammatory mediators in astroglia

  2005cites this paper
• The p75 neurotrophin receptor in human development and disease.

  2005cites this paper
• p75NTR--live or let die.

  2005influential citation
• Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease – is this type 3 diabetes?

  2005cites this paper
• Molecular characterization of neurohybrid cell death induced by Alzheimer's amyloid‐β peptides via p75NTR/PLAIDD

  2004cites this paper
• APP, NGF & the 'Sunday-driver' in a Trolley on the Road

  2004cites this paper
• Cytotoxic mechanisms by M239V presenilin 2, a little‐analyzed Alzheimer's disease‐causative mutant

  2004influential citation
• Humanin

  2004cites this paper
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  2004cites this paper
• Amyloid beta-peptide interactions with neuronal and glial cell plasma membrane: binding sites and implications for Alzheimer's disease.

  2004cites this paper
• Neuroprotective effect of activity‐dependent neurotrophic factor against toxicity from familial amyotrophic lateral sclerosis‐linked mutant SOD1 in vitro and in vivo

  2004cites this paper
• Amyloid β‐peptide interactions with neuronal and glial cell plasma membrane: binding sites and implications for Alzheimer's disease

  2004cites this paper
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  2004cites this paper