Replication challenges

The ability to test validity by replicating experiments and comparing results is a cornerstone of science. The events that followed publication of “Sustained virologic control in SIV+ macaques after antiretroviral and α4β7 antibody therapy” by Byrareddy et al. in Science in 2016 (hereafter Byrareddy) provide insights into some challenges associated with replication. Byrareddy reported striking efficacy of an approach for controlling simian immunodeficiency virus (SIV) in rhesus macaques in a sustained manner, a result of potential importance for treatment of human HIV disease. Three papers in this issue report attempts to replicate these results. The matters associated with Byrareddy and these studies provide a concrete framework for discussing our policies related to replication studies.

• Publication year

  2019

• Venue

  Science

• Publication date

  2019-09-06

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1126/science.aaz2701PMID 31488663
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• No references are available for this paper.

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