Serum YKL40: A novel potential link between inflammation and dyslipidemia in acne vulgaris

Acne vulgaris (AV) is an inflammatory skin disorder that may be associated with metabolic disorders. The relation between lipid profile in acne is not widely investigated. Chitinase‐3‐like protein 1 (YKL‐40) has been found to be implicated in different inflammatory conditions.

• Publication year

  2020

• Venue

  Journal of Cosmetic Dermatology

• Publication date

  2020-05-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1111/jocd.13124PMID 31490625
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Glycoprotein YKL-40: A potential biomarker of disease activity in rheumatoid arthritis during intensive treatment with csDMARDs and infliximab. Evidence from the randomised controlled NEO-RACo trial

  2017cited by this paper
• Investigation of the Levels of Serum Amyloid A, YKL‐40, and Pentraxin‐3 in Patients with Familial Mediterranean Fever

  2016cited by this paper
• Serum YKL-40 and MDA levels in Behcet disease.

  2016cited by this paper
• Elevated Plasma YKL-40, Lipids and Lipoproteins, and Ischemic Vascular Disease in the General Population

  2015cited by this paper
• Study of lipid profile in adult women with acne

  2015cited by this paper
• Acne patients frequently associated with abnormal plasma lipid profile

  2015cited by this paper
• Plasma Levels of the Proinflammatory Chitin‐Binding Glycoprotein YKL‐40, Variation in the Chitinase 3‐Like 1 Gene (CHI3L1), and Incident Cardiovascular Events

  2014cited by this paper
• Serum lipid profile in female patients with severe acne vulgaris.

  2014cited by this paper
• The role of inflammation in the pathology of acne.

  2013cited by this paper
• The Association between Genetic Variations of CHI3L1, Levels of the Encoded Glycoprotein YKL-40 and the Lipid Profile in a Danish Population

  2012cited by this paper
• Acne analysis, grading and computational assessment methods: an overview

  2012cited by this paper
• YKL-40 levels are independently associated with albuminuria in type 2 diabetes

  2011cited by this paper
• Role of chitin and chitinase/chitinase-like proteins in inflammation, tissue remodeling, and injury.

  2011cited by this paper
• The influence of statin treatment on the inflammatory biomarkers YKL-40 and HsCRP in patients with stable coronary artery disease

  2011cited by this paper
• The relationship of lipid profile and menstrual cycle with acne vulgaris.

  2010cited by this paper
• YKL-40: a novel prognostic fluid biomarker for preclinical Alzheimer's disease.

  2010cited by this paper
• Abstract 15383: Elevated Plasma YKL-40 Levels and Ischemic Stroke in the General Population

  2010cited by this paper
• Lipid Mediators in Acne

  2010cited by this paper
• Changes in the hormone and lipid profile of obese adolescent Saudi females with acne vulgaris.

  2009cited by this paper
• Associations of diet and lifestyle with hyperlipidemia for middle-aged and elderly persons among the Guangxi Bai Ku Yao and Han populations.

  2008cited by this paper
• Cardiometabolic abnormalities in the polycystic ovary syndrome: pharmacotherapeutic insights.

  2008cited by this paper
• Evolution of Mammalian Chitinase(-Like) Members of Family 18 Glycosyl Hydrolases

  2007cited by this paper
• The Relationship between Blood Lipids Profile and Acne

  2007cited by this paper
• Factors believed by Jordanian acne patients to affect their acne condition.

  2006cited by this paper
• Peroxidated squalene induces the production of inflammatory mediators in HaCaT keratinocytes: a possible role in acne vulgaris.

  2006cited by this paper
• Studies on serum YKL-40 as a biomarker in diseases with inflammation, tissue remodelling, fibroses and cancer.

  2006cited by this paper
• Acne and sebaceous gland function.

  2004cited by this paper
• Ethnic differences in atherosclerosis, cardiovascular disease and lipid metabolism

  2004cited by this paper
• Structure and Ligand-induced Conformational Change of the 39-kDa Glycoprotein from Human Articular Chondrocytes*

  2003cited by this paper
• Primary prevention of coronary heart disease in women through diet and lifestyle.

  2000cited by this paper
• The distribution of YKL-40 in osteoarthritic and normal human articular cartilage.

  1999cited by this paper
• Gp38k, a protein synthesized by vascular smooth muscle cells, stimulates directional migration of human umbilical vein endothelial cells.

  1999cited by this paper
• Molecular characterization of the gene for human cartilage gp-39 (CHI3L1), a member of the chitinase protein family and marker for late stages of macrophage differentiation.

  1997cited by this paper
• Induction and expression of human cartilage glycoprotein 39 in rheumatoid inflammatory and peripheral blood monocyte-derived macrophages.

  1997cited by this paper
• Lipoprotein metabolism and lipoprotein lipase in severe cystic acne.

  1985cited by this paper
• Low levels of HDL in severe cystic acne.

  1982cited by this paper

• Alterations in the lipid profile in acne vulgaris patients: A meta-analysis

  2026cites this paper
• Exploring links between acne and metabolic syndrome: a narrative review

  2025cites this paper
• Current perspectives for metabolomics and lipidomics in dyslipidemia of acne vulgaris: a mini review

  2025cites this paper
• Changes in metabolic parameters and serum YKL-40 levels in Chinese rheumatoid arthritis patients during tocilizumab therapy

  2024cites this paper
• Serum YKL-40 in coronary heart disease: linkage with inflammatory cytokines, artery stenosis, and optimal cut-off value for estimating major adverse cardiovascular events

  2023cites this paper
• YKL-40 promotes chemokine expression following drug-induced liver injury via TF-PAR1 pathway in mice

  2023influential citation
• Evaluation of the Effect of Oral Isotretinoin on the Level of Serum YKL40 in Acne Vulgaris Patients: A Cross-Sectional Case-Control

  2023cites this paper
• Chitinase-3 protein-like-1 as inflammatory marker and disturbed lipid-profile risk in acne vulgaris

  2022cites this paper
• Chitinase-3-like Protein 1 (YKL-40): A New Biomarker of Inflammation in Pyoderma Gangrenosum

  2021cites this paper
• Corrigendum

  2021cites this paper
• Assessment of YKL-40, lipid profile, antioxidant status, and some trace elements in benign and malignant breast proliferation

  2020cites this paper