Mammalian kinetochores count attached microtubules in a sensitive and switch-like manner

Jonathan Kuhn,S. Dumont

Published 2019 in Journal of Cell Biology

ABSTRACT

Kinetochores monitor their attachment to spindle microtubules to control spindle assembly checkpoint (SAC) signaling and cell cycle progression. Kuhn and Dumont show that individual mammalian kinetochores monitor the number of attached microtubules as a single unit in a sensitive and switch-like manner.

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