[Predictive assays for responses of tumors and normal tissues in radiation oncology].

The impact of curative radiotherapy depends mainly on the total dose delivered homogenously in the target volume. Tumor sensitivity to radiotherapy may be particularly inconstant depending on location, histology, somatic genetic parameters and the capacity of the immune system to infiltrate the tumor. In addition, the dose delivered to the surrounding healthy tissues may reduce the therapeutic ratio of many radiation treatments. In a same population treated in one center with the same technique, it appears that individual radiosensitivity clearly exists, namely in terms of late side effects that are in principle non-reversible. This review details the different radiobiological approaches that have been developed to better predict the tumor response but also the radiation-induced late effects.

• Publication year

  2019

• Venue

  Cancer Radiothérapie

• Publication date

  2019-08-23

• Fields of study

  Medicine

• Identifiers
  DOI 10.1016/j.canrad.2019.07.152PMID 31451357
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Rapid Clearance Profile of Plasma Circulating Tumor HPV Type 16 DNA during Chemoradiotherapy Correlates with Disease Control in HPV-Associated Oropharyngeal Cancer

  2019cited by this paper
• Peripheral memory and naïve T cells in non-small cell lung cancer patients with lung metastases undergoing stereotactic body radiotherapy: predictors of early tumor response

  2019cited by this paper
• OC-0647 Analysis of biomarkers for late radiotherapy toxicity in the REQUITE project

  2019cited by this paper
• microRNAs expression profile related with response to preoperative radiochemotherapy in patients with locally advanced gastric cancer

  2018cited by this paper
• The hallmarks of successful anticancer immunotherapy

  2018cited by this paper
• The alfa and beta of tumours: a review of parameters of the linear-quadratic model, derived from clinical radiotherapy studies

  2018cited by this paper
• A Five-MicroRNA Signature Predicts Survival and Disease Control of Patients with Head and Neck Cancer Negative for HPV Infection

  2018cited by this paper
• Significance of tumor‐infiltrating lymphocytes before and after neoadjuvant therapy for rectal cancer

  2018cited by this paper
• Overexpression of the MRE11-RAD50-NBS1 (MRN) complex in rectal cancer correlates with poor response to neoadjuvant radiotherapy and prognosis

  2018cited by this paper
• A radiosensitivity gene signature and PD-L1 status predict clinical outcome of patients with invasive breast carcinoma in The Cancer Genome Atlas (TCGA) dataset.

  2017cited by this paper
• A genome-based model for adjusting radiotherapy dose (GARD): a retrospective, cohort-based study.

  2017cited by this paper
• Precision Oncology and Genomically Guided Radiation Therapy, A Report From the ASTRO/AAPM/NCI Precision Medicine Conference

  2017cited by this paper
• Precision Oncology and Genomically Guided Radiation Therapy: A Report From the American Society for Radiation Oncology/American Association of Physicists in Medicine/National Cancer Institute Precision Medicine Conference.

  2017cited by this paper
• Tumour radiosensitivity is associated with immune activation in solid tumours.

  2017cited by this paper
• Prognostic impact of HPV-associated p16-expression and smoking status on outcomes following radiotherapy for oropharyngeal cancer: The MARCH-HPV project.

  2017cited by this paper
• The radiosensitivity of brain metastases based upon primary histology utilizing a multigene index of tumor radiosensitivity.

  2017cited by this paper
• Utilization of a Genomic Classifier for Prediction of Metastasis Following Salvage Radiation Therapy after Radical Prostatectomy.

  2016cited by this paper
• CD8 þ T cell response to human papillomavirus 16 E7 is able to predict survival outcome in oropharyngeal cancer

  2016cited by this paper
• Development and validation of a 24-gene predictor of response to postoperative radiotherapy in prostate cancer: a matched, retrospective analysis.

  2016cited by this paper
• CD8+ T cell response to human papillomavirus 16 E7 is able to predict survival outcome in oropharyngeal cancer.

  2016cited by this paper
• Investigating molecular alterations to profile short- and long-term recurrence-free survival in patients with primary glioblastoma.

  2015cited by this paper
• The radiosensitivity index predicts for overall survival in glioblastoma

  2015cited by this paper
• Radiosensitivity index predicts for survival with adjuvant radiation in resectable pancreatic cancer.

  2015cited by this paper
• Radiation-induced CD8 T-lymphocyte Apoptosis as a Predictor of Breast Fibrosis After Radiotherapy: Results of the Prospective Multicenter French Trial☆

  2015cited by this paper
• Integration of a Radiosensitivity Molecular Signature Into the Assessment of Local Recurrence Risk in Breast Cancer.

  2015cited by this paper
• The pretreatment neutrophil-to-lymphocyte ratio predicts therapeutic response to radiation therapy and concurrent chemoradiation therapy in uterine cervical cancer

  2015cited by this paper
• Differences Between Colon Cancer Primaries and Metastases Using a Molecular Assay for Tumor Radiation Sensitivity Suggest Implications for Potential Oligometastatic SBRT Patient Selection.

  2014cited by this paper
• Relationship between radiation-induced apoptosis of T lymphocytes and chronic toxicity in patients with prostate cancer treated by radiation therapy: a prospective study.

  2014cited by this paper
• Next-generation sequencing identifies germline MRE11A variants as markers of radiotherapy outcomes in muscle-invasive bladder cancer

  2014cited by this paper
• HPV in

  2014cited by this paper
• Next-generation sequencing identifies germline MRE11A variants as markers of radiotherapy outcomes in muscle-invasive bladder cancer.

  2014cited by this paper
• HPV16 DNA status is a strong prognosticator of loco-regional control after postoperative radiochemotherapy of locally advanced oropharyngeal carcinoma: results from a multicentre explorative study of the German Cancer Consortium Radiation Oncology Group (DKTK-ROG).

  2014cited by this paper
• HNSCC cell lines positive for HPV and p16 possess higher cellular radiosensitivity due to an impaired DSB repair capacity.

  2013cited by this paper
• Prognostic utility of cell cycle progression score in men with prostate cancer after primary external beam radiation therapy.

  2013cited by this paper
• Independent validation of genes and polymorphisms reported to be associated with radiation toxicity: a prospective analysis study.

  2012cited by this paper
• Abstract 678: Validation of a radiosensitivity molecular signature in breast cancer

  2012cited by this paper
• Prognostic value of an RNA expression signature derived from cell cycle proliferation genes in patients with prostate cancer: a retrospective study.

  2011cited by this paper
• Plasma citrulline levels predict intestinal toxicity in patients treated with pelvic radiotherapy

  2011cited by this paper
• A bioinformatics approach for biomarker identification in radiation-induced lung inflammation from limited proteomics data.

  2011cited by this paper
• A radiation-induced gene expression signature as a tool to predict acute radiotherapy-induced adverse side effects.

  2011cited by this paper
• Genome-wide association study to identify single nucleotide polymorphisms (SNPs) associated with the development of erectile dysfunction in African-American men after radiotherapy for prostate cancer.

  2010cited by this paper
• Transcriptional modulation of micro-RNA in human cells differing in radiation sensitivity

  2010cited by this paper
• Concurrent or sequential adjuvant letrozole and radiotherapy after conservative surgery for early-stage breast cancer (CO-HO-RT): a phase 2 randomised trial.

  2010cited by this paper
• Radiation-induced lymphocyte apoptosis to predict radiation therapy late toxicity in prostate cancer patients.

  2009cited by this paper
• A gene expression model of intrinsic tumor radiosensitivity: prediction of response and prognosis after chemoradiation.

  2009cited by this paper
• Genetic variants and normal tissue toxicity after radiotherapy: a systematic review.

  2009cited by this paper
• Single Nucleotide Polymorphisms, Apoptosis, and the Development of Severe Late Adverse Effects After Radiotherapy

  2008cited by this paper
• From cellular to high-throughput predictive assays in radiation oncology: challenges and opportunities.

  2008cited by this paper
• In vitro radiation‐induced expression of XPC mRNA as a possible biomarker for developing adverse reactions during radiotherapy

  2007cited by this paper
• Intact Mre11/Rad50/Nbs1 complex predicts good response to radiotherapy in early breast cancer.

  2007cited by this paper
• Discovering clinical biomarkers of ionizing radiation exposure with serum proteomic analysis.

  2006cited by this paper
• Radiation-induced changes in gene expression involve recruitment of existing messenger RNAs to and away from polysomes.

  2006cited by this paper
• Constitutive mRNA expression of DNA repair-related genes as a biomarker for clinical radio-resistance: A pilot study in prostate cancer patients receiving radiotherapy

  2006cited by this paper
• Prognostic/Clinical Prediction Models: Multivariable Prognostic Models: Issues in Developing Models, Evaluating Assumptions and Adequacy, and Measuring and Reducing Errors

  2005cited by this paper
• REporting recommendations for tumor MARKer prognostic studies (REMARK)

  2005cited by this paper
• CD4 and CD8 T-Lymphocyte Apoptosis Can Predict Radiation-Induced Late Toxicity: A Prospective Study in 399 Patients

  2005cited by this paper
• Cytokine profiling for prediction of symptomatic radiation-induced lung injury.

  2005cited by this paper
• Clinical trial designs for predictive marker validation in cancer treatment trials.

  2005cited by this paper
• Prediction of radiation sensitivity using a gene expression classifier.

  2005cited by this paper
• Radiation-Induced Micronucleus Frequency in Peripheral Blood Lymphocytes is Correlated with Normal Tissue Damage in Patients with Cervical Carcinoma Undergoing Radiotherapy

  2003cited by this paper
• Personal characteristics, therapy modalities and individual DNA repair capacity as predictive factors of acute skin toxicity in an unselected cohort of breast cancer patients receiving radiotherapy.

  2003cited by this paper
• Radiation-Induced Comet-Formation in Human Skin Fibroblasts from Radiotherapy Patients with Different Normal Tissue Reactions

  1999cited by this paper
• Radiation-induced micronucleus formation in human skin fibroblasts of patients showing severe and normal tissue damage after radiotherapy.

  1998cited by this paper
• Low predictive value of intrinsic fibroblast radiosensitivity for fibrosis development following radiotherapy for breast cancer.

  1998cited by this paper
• Plasma transforming growth factor beta1 as a predictor of radiation pneumonitis.

  1998cited by this paper
• No predictive value of the micronucleus assay for patients with severe acute reaction of normal tissue after radiotherapy.

  1998cited by this paper
• Rapid assay of intrinsic radiosensitivity based on apoptosis in human CD4 and CD8 T-lymphocytes.

  1997cited by this paper
• Plasma transforming growth factor β1 as a predictor of radiation pneumonitis

  1997cited by this paper
• A comparison of the radiosensitivity of lymphocytes from normal donors, cancer patients, individuals with ataxia-telangiectasia (A-T) and A-T heterozygotes.

  1995cited by this paper
• Optimal detection of apoptosis by flow cytometry depends on cell morphology.

  1993cited by this paper
• Prediction of normal-tissue tolerance to radiotherapy from in-vitro cellular radiation sensitivity.

  1992cited by this paper
• Testing for qualitative interactions between treatment effects and patient subsets.

  1985cited by this paper
• Ataxia telangiectasia: a human mutation with abnormal radiation sensitivity

  1975cited by this paper
• A Survival Curve for Mammalian Cells irradiated in vivo

  1959cited by this paper
• ACTION OF X-RAYS ON MAMMALIAN CELLS

  1956cited by this paper

• Tumour and normal tissue radiosensitivity: 2025 update.

  2025cites this paper
• Genetic Polymorphisms in ERCC1 Gene and Their Association with Response to Radiotherapy in Moroccan Patients with Nasopharyngeal Carcinoma

  2023cites this paper
• The role of ferroptosis in acute lung injury

  2022cites this paper
• Benefits of functional assays in personalized cancer medicine: more than just a proof-of-concept

  2021cites this paper
• Tumour and normal tissue radiosensitivity.

  2021cites this paper