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Modern aspects for preventive therapy of type 2 diabetes mellitus

V. Salukhov,B. V. Romashevsky

Published 2019 in Medical Council

ABSTRACT

Review article is devoted to the main directions of prevention of diabetes, which remains one of the main causes of death and disability in most countries of the world. Prevention of 2 type diabetes requires a modifying effect on the pathological processes leading to diabetes in order to slow down, stop or reverse the development of β -cell dysfunction and insulin resistance of the tissues. In the absence of a clinical effect from non-drug methods of prevention, it is advisable to use drugs that reduce insulin resistance and dysfunction of β -cells. The results of research indicate that biguanides, α -glucosidase inhibitors, orlistat, thiazolidinediones reduce the risk of developing T2D to varying degrees. Metformin has the largest evidence base, and its prolonged form is a registered indication in the Russian Federation as a drug therapy for patients with prediabetes. For other drugs we need to consider cost, side effects and long-term efficacy. The questions about the possibility of personalization of treatment-and-prophylactic measures based on algorithms, including phenotypic, genetic and microbiome features of patients with prediabetes, are discussed now.

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