Effects of Oxytocin on Placebo and Nocebo Effects in a Pain Conditioning Paradigm: A Randomized Controlled Trial

Highlights • Placebo analgesia and nocebo hyperalgesia can be induced by classical conditioning.• Oxytocin does not enhance placebo effect or decrease nocebo effect.• Oxytocin does not influence extinction of placebo and nocebo responses.

• Publication year

  2020

• Venue

  Journal of Pain

• Publication date

  2020-03-01

• Fields of study

  Medicine, Psychology

• Identifiers
  DOI 10.1016/j.jpain.2019.08.010PMID 31494273PMCID 7408480
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Enhancing Placebo Effects in Somatic Symptoms Through Oxytocin

  2018cited by this paper
• The effect of dopamine on conditioned placebo analgesia in healthy individuals: a double-blind randomized trial

  2018cited by this paper
• Sex-dependent regulation of social reward by oxytocin: an inverted U hypothesis

  2018cited by this paper
• Autonomic Arousal as a Mechanism of the Persistence of Nocebo Hyperalgesia.

  2017cited by this paper
• The Placebo Analgesic Effect in Healthy Individuals and Patients: A Meta-Analysis

  2017cited by this paper
• Kinetics and Dose Dependency of Intranasal Oxytocin Effects on Amygdala Reactivity.

  2017cited by this paper
• Sex-specific effects of intranasal oxytocin on thermal pain perception: A randomised, double-blind, placebo-controlled cross-over study.

  2017cited by this paper
• In the face of pain: The choice of visual cues in pain conditioning matters

  2017cited by this paper
• Vasopressin Boosts Placebo Analgesic Effects in Women: A Randomized Trial.

  2016cited by this paper
• Oxytocin Facilitates Pavlovian Fear Learning in Males

  2016cited by this paper
• Neurobiological effects of repeated radiofrequency exposures in male senescent rats

  2016cited by this paper
• Pain modulation by intranasal oxytocin and emotional picture viewing — a randomized double-blind fMRI study

  2016cited by this paper
• Low dose intranasal oxytocin delivered with Breath Powered device dampens amygdala response to emotional stimuli: A peripheral effect-controlled within-subjects randomized dose-response fMRI trial.

  2016cited by this paper
• Nocebo Hyperalgesia, Partial Reinforcement, and Extinction.

  2015cited by this paper
• Oxytocin facilitates the extinction of conditioned fear in humans.

  2015cited by this paper
• Role of Conditioning and Verbal Suggestion in Placebo and Nocebo Effects on Itch

  2014cited by this paper
• Intranasal Oxytocin Administration is Associated With Enhanced Endogenous Pain Inhibition and Reduced Negative Mood States

  2014cited by this paper
• Partial reinforcement, extinction, and placebo analgesia

  2014cited by this paper
• Sex differences in the neural and behavioral response to intranasal oxytocin and vasopressin during human social interaction.

  2014cited by this paper
• The Effect of Intranasal Oxytocin Administration on Acute Cold Pressor Pain: A Placebo-Controlled, Double-Blind, Within-Participants Crossover Investigation

  2014cited by this paper
• Gender moderates the effect of oxytocin on social judgments

  2014cited by this paper
• The magnitude of nocebo effects in pain: A meta‐analysis

  2014cited by this paper
• Oxytocin and vasopressin effects on the neural response to social cooperation are modulated by sex in humans

  2014cited by this paper
• Oxytocin nasal spray in fibromyalgic patients

  2014cited by this paper
• Effect of oxytocin on placebo analgesia: a randomized study.

  2013cited by this paper
• Elevated cerebrospinal fluid and blood concentrations of oxytocin following its intranasal administration in humans

  2013cited by this paper
• Salivary levels of oxytocin remain elevated for more than two hours after intranasal oxytocin administration.

  2012cited by this paper
• Nonconscious activation of placebo and nocebo pain responses

  2012cited by this paper
• Elevated Salivary Levels of Oxytocin Persist More than 7 h after Intranasal Administration

  2012cited by this paper
• Intranasal oxytocin attenuates the cortisol response to physical stress: a dose-response study.

  2012cited by this paper
• How placebo responses are formed: a learning perspective

  2011cited by this paper
• Oxytocin Enhances Amygdala-Dependent, Socially Reinforced Learning and Emotional Empathy in Humans

  2010cited by this paper
• Conditioned reflexes: An investigation of the physiological activity of the cerebral cortex

  2010cited by this paper
• How the number of learning trials affects placebo and nocebo responses

  2010cited by this paper
• Growth hormone-releaser diet attenuates beta-amyloid(1-42)-induced cognitive impairment via stimulation of the insulin-like growth factor (IGF)-1 receptor in mice.

  2009cited by this paper
• The story of O – is oxytocin the mediator of the placebo response?

  2009cited by this paper
• Mechanisms of placebo and placebo-related effects across diseases and treatments.

  2008cited by this paper
• The role of learning in nocebo and placebo effects

  2008cited by this paper
• G*Power 3: A flexible statistical power analysis program for the social, behavioral, and biomedical sciences

  2007cited by this paper
• Menstrual cycle-related changes in plasma oxytocin are relevant to normal sexual function in healthy women.

  2005cited by this paper
• Conscious Expectation and Unconscious Conditioning in Analgesic, Motor, and Hormonal Placebo/Nocebo Responses

  2003cited by this paper
• The contributions of suggestion, desire, and expectation to placebo effects in irritable bowel syndrome patients: An empirical investigation

  2003cited by this paper
• Blockade of nocebo hyperalgesia by the cholecystokinin antagonist proglumide

  1997cited by this paper
• Distinguishing optimism from neuroticism (and trait anxiety, self-mastery, and self-esteem): a reevaluation of the Life Orientation Test.

  1994cited by this paper
• The development of a six-item short-form of the state scale of the Spielberger State-Trait Anxiety Inventory (STAI).

  1992cited by this paper
• Case Western Reserve University

  1990cited by this paper
• Development and validation of brief measures of positive and negative affect: the PANAS scales.

  1988cited by this paper

• Clinical neuroscience and neurobiology of placebo and nocebo effects.

  2025cites this paper
• The role of observational learning in the formation of placebo and nocebo effects.

  2025cites this paper
• The Role of Oxytocin and Sex in Analgesic Placebo-Response: Exploratory Analysis from a Sham Randomized Clinical Trial in Chronic Back-Pain Patients

  2025cites this paper
• Investigation of whether oxytocin and trust play a role in placebo effects of marketing actions

  2025cites this paper
• Fatigue in multiple sclerosis: A scoping review of pharmacological and nonpharmacological interventions

  2025cites this paper
• Learning by observing: a systematic exploration of modulatory factors and the impact of observationally induced placebo and nocebo effects on treatment outcomes

  2024cites this paper
• Mitigating the Nocebo Effect in Biosimilar Use and Switching: A Systematic Review

  2024cites this paper
• Social learning of placebo effects in pain: a critical review of the literature and a proposed revised model.

  2024cites this paper
• The role of self-reported and physiological stress in nocebo hyperalgesia.

  2024cites this paper
• The neural dynamics of positive and negative expectations of pain

  2024cites this paper
• Efficacy and safety of novel biologics in the treatment of lupus nephritis based on registered clinical trials: a systematic review and network meta-analysis

  2023cites this paper
• The optimal learning cocktail for placebo analgesia: a randomized controlled trial comparing individual and combined techniques.

  2023cites this paper
• Electrophysiological markers for anticipatory processing of nocebo-augmented pain

  2023cites this paper
• Oxytocin and the Social Facilitation of Placebo Effects

  2022cites this paper
• Placebo effects on cutaneous pain and itch: a systematic review and meta-analysis of experimental results and methodology

  2022cites this paper
• Placebo and nocebo effects: from observation to harnessing and clinical application

  2022cites this paper
• Effects of intranasal oxytocin on pain perception among human subjects: A systematic literature review and meta-analysis.

  2022cites this paper
• The relationship between expectancy, anxiety, and the nocebo effect: a systematic review and meta-analysis with recommendations for future research

  2022cites this paper
• Informed Consent for Placebo-Controlled Trials: Do Ethics and Science Conflict?

  2022cites this paper
• European Headache Federation recommendations for placebo and nocebo terminology

  2020cites this paper
• Neurobiologische Grundlagen der Placebo-Analgesie

  2020cites this paper
• Reply to the Letter to the Editor: “Lack of Evidence for the Effect of Oxytocin on Placebo Analgesia and Nocebo Hyperalgesia”

  2020cites this paper
• Lack of Evidence for the Effect of Oxytocin on Placebo Analgesia and Nocebo Hyperalgesia

  2019cites this paper