Effects of red ginseng on the elastic properties of human skin

Background Red ginseng contains components, including microelements, vitamins, essential oils, and fatty acids, that can be used in skincare to delay the aging process. We investigated the effects of red ginseng treatment on skin elasticity by assessing cellular stiffness and measuring collagen protein synthesis. Methods Human dermal fibroblasts were treated with red ginseng, and the resulting changes in stiffness were investigated using atomic force microscopy. Cytoskeletal changes and mRNA expression of biomarkers of aging, including that of procollagens I and VII, elastin, and fibrillin-1, were investigated. Collagen in a human skin equivalent treated with red ginseng was visualized via hematoxylin and eosin staining, scanning electron microscopy, and atomic force microscopy. Results and conclusion The stiffness of fibroblasts was significantly reduced by treatment with red ginseng concentrations of ≥ 0.8 mg/mL. The ratio of F-actin to G-actin decreased after treatment, which corresponded to a change in fibroblast stiffness. The storage modulus (G′) and loss modulus (G″) of the skin equivalent were both lowered by red ginseng treatment. This result indicates that the viscoelasticity of the skin equivalent can be restored by red ginseng treatment.

• Publication year

  2019

• Venue

  Journal of Ginseng Research

• Publication date

  2019-08-21

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.jgr.2019.08.004PMID 32913403PMCID 7471210
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Intracellular Trafficking Modulation by Ginsenoside Rg3 Inhibits Brucella abortus Uptake and Intracellular Survival within RAW 264.7 Cells.

  2017cited by this paper
• Experimental and computational assessment of F-actin influence in regulating cellular stiffness and relaxation behaviour of fibroblasts.

  2016cited by this paper
• Effects of Korean ginseng berry on skin antipigmentation and antiaging via FoxO3a activation

  2016cited by this paper
• Age-related changes of blood vessels in the human dermis

  2015cited by this paper
• Role of Age-Associated Alterations of the Dermal Extracellular Matrix Microenvironment in Human Skin Aging: A Mini-Review

  2015cited by this paper
• A single-center, randomized, double-blind, placebo-controlled study on the efficacy and safety of “enzyme-treated red ginseng powder complex (BG11001)” for antiwrinkle and proelasticity in individuals with healthy skin

  2015cited by this paper
• Quantification of maltol in Korean ginseng (Panax ginseng) products by high-performance liquid chromatography-diode array detector

  2015cited by this paper
• Ultrasound elastography - review of techniques and its clinical applications.

  2014cited by this paper
• Actin-binding proteins differentially regulate endothelial cell stiffness, ICAM-1 function and neutrophil transmigration

  2014cited by this paper
• Comparison of skin elasticity test results from the Ballistometer® and Cutometer®

  2014cited by this paper
• Morphological Studies on the Inhibitory Effects of Photoaging Skin of Fermented Red Ginseng in Hairless Mice

  2014cited by this paper
• Age-Related Changes in the Mechanical Properties of Human Fibroblasts and Its Prospective Reversal After Anti-Wrinkle Tripeptide Treatment

  2013cited by this paper
• The effect of probe to skin contact force on Cutometer MPA 580 measurements

  2013cited by this paper
• Determining elastic properties of skin by measuring surface waves from an impulse mechanical stimulus using phase-sensitive optical coherence tomography

  2012cited by this paper
• Skin anti-aging strategies

  2012cited by this paper
• Actin structure and function.

  2011cited by this paper
• Ginseng (Panax quinquefolius) Attenuates Leptin-Induced Cardiac Hypertrophy through Inhibition of p115Rho Guanine Nucleotide Exchange Factor-RhoA/Rho-Associated, Coiled-Coil Containing Protein Kinase-Dependent Mitogen-Activated Protein Kinase Pathway Activation

  2011cited by this paper
• 유산균 발효에 의한 인삼열매 추출물의 항산화 및 항노화 효과

  2011cited by this paper
• Stiffening of human skin fibroblasts with age.

  2010cited by this paper
• ANALYSIS OF VISCOELASTICITY OF HUMAN SKIN FOR PREVENTION OF PRESSURE ULCERS

  2008cited by this paper
• Transport of messenger RNA from the nucleus to the cytoplasm.

  2006cited by this paper
• Sirtuins in aging and age-related disease.

  2006cited by this paper
• Skin Treatments and Dermatological Procedures to Promote Youthful Skin

  2006cited by this paper
• Collagens — structure , function , and biosynthesis

  2003cited by this paper
• Collagens--structure, function, and biosynthesis.

  2003cited by this paper
• Study of atomic force microscopy force-distance curves by simulation using the Connolly surface for proteins

  2002cited by this paper
• Skin ageing: changes of physical properties of human skin in vivo

  2001cited by this paper
• Function and regulation of AP-1 subunits in skin physiology and pathology

  2001cited by this paper
• Fibrillin-rich microfibrils are reduced in photoaged skin. Distribution at the dermal-epidermal junction.

  1999cited by this paper
• Force-distance curves by atomic force microscopy

  1999cited by this paper
• Shear wave elasticity imaging: a new ultrasonic technology of medical diagnostics.

  1998cited by this paper
• Elastography: A Quantitative Method for Imaging the Elasticity of Biological Tissues

  1991cited by this paper
• Aging and cross-linking of skin collagen.

  1988cited by this paper
• Cytoskeletal protein synthesis and organization in cultured mouse osteoblastic cells Effects of cell density

  1987cited by this paper
• Regulation of collagen synthesis.

  1982cited by this paper
• THE STRUCTURE OF HUMAN SKIN COLLAGEN AS STUDIED WITH THE ELECTRON MICROSCOPE

  1948cited by this paper

• Red ginseng-derived components attenuate UVB-induced keratinocyte senescence via senomorphic mechanisms

  2026cites this paper
• Multifunctional Natural Herbal Extracts Liposomal Loaded Hybrid Hydrogel for Skin Improvement and Repair

  2025cites this paper
• Poly-l-Lactic Acid Alleviates UVB-Induced Photoaging of Dermal Fibroblast (Hs68) and Promotes Collagen Production Through the MAPK/AP-1 Pathway.

  2025cites this paper
• Nrf2 signaling in bone health: unlocking new avenues for osteoporosis management

  2025cites this paper
• Activation of Piezo 1 in the Pathogenesis of Glaucoma

  2025cites this paper
• A Multi-center Trial Evaluating a Serum Comprised of Plant-based Adaptogens Targeting Skin Quality.

  2024cites this paper
• Combination of red ginseng and velvet antler extracts prevents skin damage by enhancing the antioxidant defense system and inhibiting MAPK/AP-1/NF-κB and caspase signaling pathways in UVB-irradiated HaCaT keratinocytes and SKH-1 hairless mice

  2024cites this paper
• Gene Expression Analysis of a Topical Serum Comprised of Plant-based Adaptogens Developed to Support Homeostasis and Skin Quality.

  2024cites this paper
• Methods for determining the ginseng age: A review

  2024cites this paper
• Isolation, structure, biological activity and application progress of ginseng polysaccharides from the Araliaceae family.

  2024cites this paper
• Protective effect of Korean red ginseng water extract on levothyroxine-induced hyperthyroidism and propylthiouracil-induced hypothyroidism in rats

  2024cites this paper
• Editorial: Potential of natural products as drug leads possessing antioxidant and anti-aging properties

  2022cites this paper
• Insulin secretion and α-glucosidase inhibitory effects of dicaffeoylquinic acid derivatives

  2022cites this paper
• Wound Healing Effect of Gintonin Involves Lysophosphatidic Acid Receptor/Vascular Endothelial Growth Factor Signaling Pathway in Keratinocytes

  2021cites this paper
• In Vitro Photoprotective, Anti-Inflammatory, Moisturizing, and Antimelanogenic Effects of a Methanolic Extract of Chrysophyllum lucentifolium Cronquist

  2021influential citation
• Quality Distinguish of Red Ginseng from Different Origins by HPLC–ELSD/PDA Combined with HPSEC–MALLS–RID, Focus on the Sugar-Markers

  2021cites this paper
• Numerical analysis of the strain distribution in skin domes formed upon the application of hypobaric pressure

  2020cites this paper