Compartmentalized DNA repair: Rif1 S-acylation links DNA double-strand break repair to the nuclear membrane

ABSTRACT DNA double-strand breaks (DSBs) disrupt the structural integrity of chromosomes. Proper DSB repair pathway choice is critical to avoid the type of gross chromosomal rearrangements that characterize cancer cells. Recent findings reveal S-fatty acylation and membrane anchorage of Rap1-interacting factor 1 (Rif1) as a mechanism providing spatial control over DSB repair pathway choice.

• Publication year

  2019

• Venue

  Molecular & Cellular Oncology

• Publication date

  2019-08-21

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1080/23723556.2019.1648025PMID 31692850PMCID 6816362
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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