Oxygen radical formation during cytochrome P450-catalyzed cyclosporine metabolism in rat and human liver microsomes at varying hydrogen ion concentrations

No abstract is available for this paper.

• Publication year

  1995

• Venue

  Molecular and Cellular Biochemistry

• Publication date

  1995-10-18

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1007/BF01322335PMID 8569758
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Generation of oxygen free radicals during the metabolism of cyclosporine A: a cause-effect relationship with metabolism inhibition

  1993cited by this paper
• Use of aromatase (CYP19) metabolite ratios to characterize electron transfer from NADPH-cytochrome P450 reductase.

  1993influential reference
• Adrenochrome reaction implicates oxygen radicals in metabolism of cyclosporine A and FK-506 in rat and human liver microsomes.

  1993cited by this paper
• Role of lysine and arginine residues of cytochrome P450 in the interaction between cytochrome P4502B1 and NADPH-cytochrome P450 reductase.

  1993cited by this paper
• Free radicals in toxicology.

  1993cited by this paper
• Influences of Ginkgo biloba on cyclosporin A induced lipid peroxidation in human liver microsomes in comparison to vitamin E, glutathione and N-acetylcysteine.

  1991cited by this paper
• A rapid bioassay for chemicals that induce pro‐oxidant states

  1990cited by this paper
• Biochemical abnormalities in serum and urine from renal transplant recipients receiving cyclosporine.

  1989cited by this paper
• Spin trapping of free radicals in homogenates of heart from selenium and vitamin E deficient rats.

  1988cited by this paper
• On the membrane topology of vertebrate cytochrome P-450 proteins.

  1988cited by this paper
• CYCLOSPORINE—RELATIONSHIP OF SIDE EFFECTS TO MODE OF ACTION

  1988cited by this paper
• Identification and analysis of nine metabolites of cyclosporine in whole blood by liquid chromatography. 2: Comparison of patients' results.

  1987cited by this paper
• Metabolism of cyclosporin A. II. Implication of the macrolide antibiotic inducible cytochrome P-450 3c from rabbit liver microsomes.

  1987cited by this paper
• Guanethidine N‐oxidation in human liver microsomes

  1987cited by this paper
• Aging affects the drug metabolism systems of rat liver, kidney, colon and lung in a differential fashion.

  1986cited by this paper
• Detection of in vivo lipid peroxidation using the thiobarbituric acid assay for lipid hydroperoxides.

  1986cited by this paper
• Metabolism of cyclosporine.

  1985cited by this paper
• Measurement of protein using bicinchoninic acid.

  1985cited by this paper
• Determination of the production of superoxide radicals and hydrogen peroxide in mitochondria.

  1984cited by this paper
• Pathological changes in rats receiving cyclosporin A at immunotherapeutic dosage for 7 weeks.

  1983cited by this paper
• Equilibrium properties of xanthine oxidase containing FAD analogs of varying oxidation-reduction potential.

  1981cited by this paper
• Assay of formaldehyde generated during microsomal oxidation reactions.

  1978cited by this paper
• NADPH-cytochrome P-450 reductase from rat liver: purification by affinity chromatography and characterization.

  1977cited by this paper
• THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. II. SOLUBILIZATION, PURIFICATION, AND PROPERTIES.

  1964cited by this paper

• Niclosamide modulates cyclosporin A-induced hepatotoxicity in a mouse model: PPAR-γ and Wnt/β-catenin crosstalk.

  2023cites this paper
• Cytochrome P450 enzyme-based biotransformation of pharmaceuticals and personal care products (PPCPs) by microalgae in the aquatic environment

  2023cites this paper
• Cyclosporin A Inhibits the Activation of Membrane-Bound Guanylate Cyclase GC-A of Atrial Natriuretic Factor via NAD(P)H Oxidase.

  2022cites this paper
• Crosstalk of physiological pH and chemical pKa under the umbrella of physiologically based pharmacokinetic modeling of drug absorption, distribution, metabolism, excretion, and toxicity

  2021cites this paper
• Defining the AHR-regulated transcriptome in NK cells reveals gene expression programs relevant to development and function

  2021cites this paper
• The Antioxidant Activity of Avocado seeds on Immunosuppression induced by Cyclosporine in Rats

  2020cites this paper
• Chemical Activation of the Constitutive Androstane Receptor Leads to Activation of Oxidant-Induced Nrf2

  2018cites this paper
• Thymoquinone improves the kidney and liver changes induced by chronic cyclosporine A treatment and acute renal ischaemia/reperfusion in rats

  2015cites this paper
• The effect of arbutin on lipid peroxidation and antioxidant capacity in the serum of cyclosporine-treated rats

  2015cites this paper
• The immunomodulating and antioxidant activity of fucoidan on the splenic tissue of rats treated with cyclosporine A

  2013cites this paper
• The role and regulatory mechanisms of nox1 in vascular systems

  2012cites this paper
• EFFECTS OF ENDOTOXIN ON RENAL EXCRETION OF DRUGS

  2011cites this paper
• Role of Oxidative Stress in the Colonic Complications of Murine Syngeneic Graft-versus-host Disease

  2011cites this paper
• Study of the relationship between immunosuppressive therapy and CYP3A4 activity in liver transplantations

  2011cites this paper
• Oxidative Stress in Cardiac Transplantation

  2010cites this paper
• Cyclosporine-induced changes in drug metabolizing enzymes in hyperlipemic rabbit kidneys could explain its toxicity

  2010cites this paper
• Cyclosporine-Induced Oxidative Stress and renal Dysfunction in Rat kidneys: A Possible Ameliorated Effect by Curcumin as an Antioxidant

  2009cites this paper
• Nox proteins in signal transduction.

  2009cites this paper
• Cigarette smoke-induced mitochondrial dysfunction and oxidative stress in

  2009cites this paper
• Cigarette smoke-induced mitochondrial dysfunction and oxidative stress in Toorn

  2009cites this paper
• ROLE OF OXIDATIVE STRESS AND T CELL HOMING IN THE DEVELOPMENT OF MURINE SYNGENEIC GRAFT-VERSUS-HOST DISEASE

  2009influential citation
• Cytochrome P450s: Drug–Drug Interactions

  2008cites this paper
• Effect of Hyperbaric Oxygen on Cyclosporine-Induced Nephrotoxicity and Oxidative Stress in Rats

  2007cites this paper
• Lycopene, a carotenoid, attenuates cyclosporine-induced renal dysfunction and oxidative stress in rats.

  2007cites this paper
• Cyclosporin A-induced oxidative stress is not the consequence of an increase in mitochondrial membrane potential.

  2007cites this paper
• Effects of deleting mitochondrial antioxidant genes on aging

  2007cites this paper
• Advances in predicting CYP-mediated drug interactions in the drug discovery setting

  2006cites this paper
• The effect of dimethyl sulfoxide on the function of cytochrome P450 2D6 in HepG2 cells upon the co-expression with NADPH-cytochrome P450 reductase.

  2006cites this paper
• NADPH oxidase subunits (NOX-1, p22phox, Rac-1) and tacrolimus-induced nephrotoxicity in a rat renal transplant model.

  2006cites this paper
• Redox cycling of adrenaline and adrenochrome catalysed by mitochondrial Complex I.

  2006cites this paper
• Protective effect of L-propionylcarnitine in chronic cyclosporine-a induced nephrotoxicity.

  2006cites this paper
• Green tea extract attenuates cyclosporine A-induced oxidative stress in rats.

  2005cites this paper
• Curcumin, a diferuloylmethane, attenuates cyclosporine-induced renal dysfunction and oxidative stress in rat kidneys

  2005cites this paper
• Methoxyethyl-Modified Intercellular Adhesion Molecule-1 Antisense Phosphorothiateoligonucleotides Inhibit Allograft Rejection, Ischemic-Reperfusion Injury, and Cyclosporine-Induced Nephrotoxicity

  2005cites this paper
• Effects of antioxidant supplementation on blood cyclosporin A and glomerular filtration rate in renal transplant recipients.

  2005cites this paper
• Oxidative and nitrosative stress in kidney disease: a case for cyclosporine A.

  2005cites this paper
• Amelioration of Cyclosporine Nephrotoxicity by Irbesartan, A Selective AT1 Receptor Antagonist

  2004cites this paper
• Cyp1a2 protects against reactive oxygen production in mouse liver microsomes.

  2004cites this paper
• Attenuation of Cyclosporine-Induced Renal Dysfunction by Catechin: Possible Antioxidant Mechanism

  2003cites this paper
• Cyclosporin A Disrupts Bradykinin Signaling Through Superoxide

  2003cites this paper
• OXIDATIVE STRESS-MEDIATED RENAL DYSFUNCTION BY CYCLOSPORINE A IN RATS: ATTENUATION BY TRIMETAZIDINE

  2002cites this paper
• Selective angiotensin II type 1 receptor blockade ameliorates cyclosporine nephrotoxicity.

  2002cites this paper
• Induction of cellular oxidative stress by aryl hydrocarbon receptor activation.

  2002cites this paper
• Cyclosporin A‐induced free radical generation is not mediated by cytochrome P‐450

  2002cites this paper
• Interaction of cyclosporine A and the renin-angiotensin system; new perspectives.

  2002cites this paper
• Superoxide limits cyclosporine-A-induced formation of peroxynitrite in endothelial cells(2).

  2002cites this paper
• The fallacy of using adrenochrome reaction for measurement of reactive oxygen species formed during cytochrome p450-mediated metabolism of xenobiotics.

  2002cites this paper
• Cyclosporin A and free radical generation.

  2001cites this paper
• Formation of peroxynitrite in vascular endothelial cells exposed to cyclosporine A

  2001cites this paper
• Nitrosative stress by cyclosporin A in the endothelium: studies with the NO-sensitive probe diaminofluorescein-2/diacetate using flow cytometry.

  2001cites this paper
• Human NADPH-P450 oxidoreductase modulates the level of cytochrome P450 CYP2D6 holoprotein via haem oxygenase-dependent and -independent pathways.

  2001cites this paper
• Quercetin, a bioflavonoid, protects against oxidative stress-related renal dysfunction by cyclosporine in rats.

  2001cites this paper
• Effect of 6 weeks of vitamin E administration on renal haemodynamic alterations following a single dose of neoral in healthy volunteers.

  2001cites this paper
• Does cyclosporin A generate free radicals?

  2000cites this paper
• In vitro metabolism of the M1-muscarinic agonist 5-(2-ethyl-2H-tetrazol-5-yl)-1-methyl-1,2,3,6-tetrahydropyridine by human hepatic cytochromes P-450 determined at pH 7.4 and 8.5.

  1999cites this paper
• Oxidative inactivation of cytochrome P-450 1A (CYP1A) stimulated by 3,3',4,4'-tetrachlorobiphenyl: production of reactive oxygen by vertebrate CYP1As.

  1999cites this paper
• Assessing the mechanism of metabolism-dependent valproic acid-induced in vitro cytotoxicity.

  1999cites this paper
• Time‐dependent Effects of Klebsiella pneumoniae Endotoxin on Hepatic Drug‐metabolizing Enzyme Activity in Rats

  1998cites this paper
• Human NADPH-P 450 oxidoreductase modulates the level of cytochrome P 450 CYP 2 D 6 holoprotein via haem oxygenase-dependent and-independent pathways

  year unknowncites this paper
• Dose-response: an International Journal Induction of Oxidative Stress Responses by Dioxin and Other Ligands of the Aryl Hydrocarbon Receptor Recommended Citation Induction of Oxidative Stress Responses by Dioxin and Other Ligands of the Aryl Hydrocarbon Receptor

  year unknowncites this paper