Positive Allosteric Modulators Differentially Affect Full versus Partial Agonist Activation of the Glycine Receptor

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Journal of Pharmacology and Experimental Therapeutics

• Publication date

  2012-07-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1124/jpet.112.191486PMID 22473615PMCID PMC3383033
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Allosteric modulation of glycine receptors

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• Glycine-activated chloride currents of neurons freshly isolated from the prefrontal cortex of young rats.

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  2010influential reference
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  2009influential reference
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  2008cited by this paper
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  2008cited by this paper
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  2008influential reference
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  2006cited by this paper
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  2006cited by this paper
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  2006cited by this paper
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  2005cited by this paper
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  2005cited by this paper
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  2005cited by this paper
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  2004cited by this paper
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  2004cited by this paper
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  2003cited by this paper
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  2002cited by this paper
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  2001cited by this paper
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  2001cited by this paper
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  2000influential reference
• Glycine and gamma-aminobutyric acid(A) receptor function is enhanced by inhaled drugs of abuse.

  2000influential reference
• Acute effects of ethanol on GABAA and glycine receptor function.

  1999cited by this paper
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  1999cited by this paper
• Enhancement of Glycine Receptor Function by Ethanol Is Inversely Correlated with Molecular Volume at Position α267*

  1998influential reference
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  1997influential reference
• Taurine increases in the nucleus accumbens microdialysate after acute ethanol administration to naive and chronically alcoholised rats.

  1996cited by this paper
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  1996influential reference
• A single amino acid determines differences in ethanol actions on strychnine-sensitive glycine receptors.

  1996influential reference
• Potentiation of gamma-aminobutyric acid type A receptor-mediated chloride currents by novel halogenated compounds correlates with their abilities to induce general anesthesia.

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  1993cited by this paper
• CNS depressant effects of volatile organic solvents.

  1991cited by this paper
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  2016cites this paper
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  2016cites this paper
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  2015cites this paper
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  2013cites this paper
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  2013influential citation