DNA 序列,这两个位点的氨基酸残基称为重复可 变的双氨基酸残基 ( Repeat variable di-residue , RVD ) ,每个重复单元能特异性识别一个碱基对。 TALEN 的唯一靶向限制是对

No abstract is available for this paper.

• Publication year

  2019

• Venue

  Unknown venue

• Publication date

  Unknown publication date

• Fields of study

  Not labeled

• Identifiers

  No identifiers available.

• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Development of a gene-editing approach to restore vision loss in Leber congenital amaurosis type 10

  2019cited by this paper
• Gene-edited babies: Chinese Academy of Medical Sciences' response and action.

  2019cited by this paper
• Open letter from Chinese HIV professionals on human genome editing.

  2019cited by this paper
• Chinese Academy of Engineering calls for actions on the birth of gene-edited infants.

  2019cited by this paper
• A Review of CRISPR-Based Genome Editing: Survival, Evolution and Challenges.

  2018cited by this paper
• Identification of preexisting adaptive immunity to Cas9 proteins in humans

  2018influential reference
• Cas9 immunity creates challenges for CRISPR gene editing therapies

  2018influential reference
• Erratum: Repair of double-strand breaks induced by CRISPR–Cas9 leads to large deletions and complex rearrangements

  2018influential reference
• p53 inhibits CRISPR–Cas9 engineering in human pluripotent stem cells

  2018cited by this paper
• CRISPR–Cas9 genome editing induces a p53-mediated DNA damage response

  2018cited by this paper
• The Hope and Hype of CRISPR-Cas9 Genome Editing: A Review

  2017cited by this paper
• Nucleic acid detection with CRISPR-Cas13a/C2c2

  2017cited by this paper
• Toward Responsible Human Genome Editing.

  2017cited by this paper
• A communal catalogue reveals Earth’s multiscale microbial diversity

  2017cited by this paper
• RNA targeting with CRISPR–Cas13

  2017cited by this paper
• Correction of β-thalassemia mutant by base editor in human embryos

  2017cited by this paper
• Recent advances in the use of ZFN-mediated gene editing for human gene therapy.

  2017influential reference
• Proceedings of the International Summit on Human Gene Editing: a global discussion—Washington, D.C., December 1–3, 2015

  2016cited by this paper
• Chinese scientists to pioneer first human CRISPR trial

  2016cited by this paper
• C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector

  2016cited by this paper
• Cas13b is a Type VI-B CRISPR-associated RNA-Guided RNase differentially regulated by accessory proteins Csx27 and Csx28

  2016cited by this paper
• Overviews and Applications of the CRISPR/Cas9 System in Plant Functional Genomics and Creation of New Plant Germplasm

  2016cited by this paper
• Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage

  2016cited by this paper
• Origins of Programmable Nucleases for Genome Engineering.

  2016cited by this paper
• Editing policy to fit the genome?

  2016cited by this paper
• CRISPR/Cas9-mediated gene editing in human tripronuclear zygotes

  2015influential reference
• An updated evolutionary classification of CRISPR–Cas systems

  2015cited by this paper
• In vivo genome editing using Staphylococcus aureus Cas9

  2015cited by this paper
• Cpf1 is a single RNA-guided endonuclease of a class 2 CRISPR-Cas system.

  2015cited by this paper
• Progress of genome editing approaches towards gene therapy

  2015cited by this paper
• CRISPR/Cas-mediated genome editing in the rat via direct injection of one-cell embryos

  2014cited by this paper
• Generation of gene-modified cynomolgus monkey via Cas9/RNA-mediated gene targeting in one-cell embryos.

  2014cited by this paper
• In vivo interrogation of gene function in the mammalian brain using CRISPR-Cas9

  2014cited by this paper
• Efficient RNA/Cas9-mediated genome editing in Xenopus tropicalis

  2014influential reference
• Fusion of catalytically inactive Cas9 to FokI nuclease improves the specificity of genome modification

  2014cited by this paper
• Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity.

  2013cited by this paper
• CRISPR-mediated modular RNA-guided regulation of transcription in eukaryotes.

  2013cited by this paper
• Generation of gene-modified mice via Cas9/RNA-mediated gene targeting

  2013cited by this paper
• Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression.

  2013influential reference
• RNA-Guided Human Genome Engineering via Cas9

  2013influential reference
• Efficient CRISPR/Cas9 genome editing with low off-target effects in zebrafish

  2013cited by this paper
• Efficient In Vivo Genome Editing Using RNA-Guided Nucleases

  2013influential reference
• A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity

  2012influential reference
• Evolution and classification of the CRISPR–Cas systems

  2011influential reference
• A TALE nuclease architecture for efficient genome editing

  2011cited by this paper
• TAL nucleases (TALNs): hybrid proteins composed of TAL effectors and FokI DNA-cleavage domain

  2010cited by this paper
• Targeting DNA Double-Strand Breaks with TAL Effector Nucleases

  2010cited by this paper
• Breaking the Code of DNA Binding Specificity of TAL-Type III Effectors

  2009cited by this paper
• A Simple Cipher Governs DNA Recognition by TAL Effectors

  2009cited by this paper
• CRISPR Provides Acquired Resistance Against Viruses in Prokaryotes

  2007cited by this paper
• Chimeric Nucleases Stimulate Gene Targeting in Human Cells

  2003cited by this paper
• Identification of genes that are associated with DNA repeats in prokaryotes

  2002influential reference
• Targeted chromosomal cleavage and mutagenesis in Drosophila using zinc-finger nucleases.

  2002cited by this paper
• Biological significance of a family of regularly spaced repeats in the genomes of Archaea, Bacteria and mitochondria

  2000influential reference
• Hybrid restriction enzymes: zinc finger fusions to Fok I cleavage domain.

  1996cited by this paper
• Nucleotide sequence of the iap gene, responsible for alkaline phosphatase isozyme conversion in Escherichia coli, and identification of the gene product

  1987influential reference
• Advances and Challenges in Gene Editing Technologies Advances and Challenges in Gene Editing Technologies

  year unknowncited by this paper

• No citing papers are available for this paper.