Caveolin-1 promotes pancreatic cancer cell differentiation and restores membranous E-cadherin via suppression of the epithelial-mesenchymal transition

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Cell Cycle

• Publication date

  2011-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.4161/cc.10.21.17895PMID 22041584PMCID PMC3266007
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The role of caveolin-1 in prostate cancer: clinical implications

  2010cited by this paper
• Epithelial-mesenchymal transition in primary human bronchial epithelial cells is Smad-dependent and enhanced by fibronectin and TNF-α

  2010cited by this paper
• Epithelial to mesenchymal transition contributes to drug resistance in pancreatic cancer.

  2009influential reference
• The basics of epithelial-mesenchymal transition.

  2009cited by this paper
• Differential enhancement of the anti-cancer effect of doxorubicin by Akt inhibitors on human breast cancer cells with differing genetic backgrounds.

  2009cited by this paper
• E-cadherin regulates metastasis of pancreatic cancer in vivo and is suppressed by a SNAIL/HDAC1/HDAC2 repressor complex.

  2009cited by this paper
• Pancreatic cancer stem cells and EMT in drug resistance and metastasis.

  2009cited by this paper
• Down-regulation of E-cadherin is an essential event in activating β-catenin/Tcf dependent transcription and expression of its target genes in Pdcd4 knock-down cells

  2009cited by this paper
• Caveolin-1 (P132L), a common breast cancer mutation, confers mammary cell invasiveness and defines a novel stem cell/metastasis-associated gene signature.

  2009cited by this paper
• Caveolin-1 Acts as a Tumor Suppressor by Down-Regulating Epidermal Growth Factor Receptor-Mitogen-Activated Protein Kinase Signaling Pathway in Pancreatic Carcinoma Cell Lines

  2009cited by this paper
• Phosphoinositide 3‐kinase/Akt pathway plays an important role in chemoresistance of gastric cancer cells against etoposide and doxorubicin induced cell death

  2008cited by this paper
• Restoration of E-cadherin cell-cell junctions requires both expression of E-cadherin and suppression of ERK MAP kinase activation in Ras-transformed breast epithelial cells.

  2008cited by this paper
• Absence of E-Cadherin Expression Distinguishes Noncohesive from Cohesive Pancreatic Cancer

  2008cited by this paper
• Restoration of caveolin-1 expression suppresses growth and metastasis of head and neck squamous cell carcinoma

  2008cited by this paper
• Co-expression of fatty acid synthase and caveolin-1 in pancreatic ductal adenocarcinoma: Implications for tumor progression and clinical outcome

  2008cited by this paper
• Snail promotes Wnt target gene expression and interacts with β-catenin

  2008cited by this paper
• Akt and XIAP regulate the sensitivity of human uterine cancer cells to cisplatin, doxorubicin and taxol

  2008cited by this paper
• Snail and Slug promote epithelial-mesenchymal transition through beta-catenin-T-cell factor-4-dependent expression of transforming growth factor-beta3.

  2008cited by this paper
• Expression of snail in pancreatic cancer promotes metastasis and chemoresistance.

  2007cited by this paper
• A tale of two proteins: Differential roles and regulation of Smad2 and Smad3 in TGF‐β signaling

  2007cited by this paper
• Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype?

  2007cited by this paper
• RAS/ERK modulates TGFbeta-regulated PTEN expression in human pancreatic adenocarcinoma cells.

  2007cited by this paper
• N-cadherin signaling potentiates mammary tumor metastasis via enhanced extracellular signal-regulated kinase activation.

  2007cited by this paper
• E-Cadherin Is Required for Caveolin-1-Mediated Down-Regulation of the Inhibitor of Apoptosis Protein Survivin via Reduced β-Catenin-Tcf/Lef-Dependent Transcription

  2007cited by this paper
• Hepatocyte growth factor induces cell scattering through MAPK/Egr‐1‐mediated upregulation of Snail

  2006cited by this paper
• Caveolin-1 deficiency (-/-) conveys premalignant alterations in mammary epithelia, with abnormal lumen formation, growth factor independence, and cell invasiveness.

  2006cited by this paper
• Muscle-specific interaction of caveolin isoforms: differential complex formation between caveolins in fibroblastic vs. muscle cells.

  2005cited by this paper
• Induction of an epithelial to mesenchymal transition in human immortal and malignant keratinocytes by TGF‐β1 involves MAPK, Smad and AP‐1 signalling pathways

  2005cited by this paper
• Distinctive regulation and function of PI 3K/Akt and MAPKs in doxorubicin‐induced apoptosis of human lung adenocarcinoma cells

  2004cited by this paper
• Caveolin-1 Gene Disruption Promotes Mammary Tumorigenesis and Dramatically Enhances Lung Metastasis in Vivo

  2004cited by this paper
• The biphasic differential expression of the cellular membrane protein, caveolin-1, in oral carcinogenesis.

  2003cited by this paper
• The protein kinase Akt induces epithelial mesenchymal transition and promotes enhanced motility and invasiveness of squamous cell carcinoma lines.

  2003influential reference
• Caveolin-1 overexpression predicts poor disease-free survival of patients with clinically confined renal cell carcinoma

  2003cited by this paper
• Expression of caveolin-1 and caveolin-2 in urothelial carcinoma of the urinary bladder correlates with tumor grade and squamous differentiation.

  2003cited by this paper
• Mechanisms of TGF-beta signaling from cell membrane to the nucleus.

  2003cited by this paper
• Mechanisms of TGF-β Signaling from Cell Membrane to the Nucleus

  2003cited by this paper
• Epithelial–mesenchymal transitions in tumour progression

  2002cited by this paper
• Mechanisms in Epithelial Plasticity and Metastasis: Insights from 3D Cultures and Expression Profiling

  2002cited by this paper
• Identification of differentially expressed genes in pulmonary adenocarcinoma by using cDNA array

  2002cited by this paper
• Caveolin-1 is down-regulated in human ovarian carcinoma and acts as a candidate tumor suppressor gene.

  2001cited by this paper
• Modulation of Akt Activity by Doxorubicin in Breast Cancer Cells

  2001cited by this paper
• Caveolin-1 expression inhibits Wnt/beta-catenin/Lef-1 signaling by recruiting beta-catenin to caveolae membrane domains.

  2000cited by this paper
• Caveolin-1 Expression Inhibits Wnt/β-Catenin/Lef-1 Signaling by Recruiting β-Catenin to Caveolae Membrane Domains*

  2000cited by this paper
• The PDZ Domains of Zonula Occludens-1 Induce an Epithelial to Mesenchymal Transition of Madin-Darby Canine Kidney I Cells

  2000cited by this paper
• Caveolin-1 levels are down-regulated in human colon tumors, and ectopic expression of caveolin-1 in colon carcinoma cell lines reduces cell tumorigenicity.

  2000cited by this paper
• Caveolins, Liquid-Ordered Domains, and Signal Transduction

  1999cited by this paper
• Reduction of caveolin 1 gene expression in lung carcinoma cell lines.

  1999cited by this paper
• Tumor cell growth inhibition by caveolin re-expression in human breast cancer cells

  1998cited by this paper
• Caveolins, a Family of Scaffolding Proteins for Organizing “Preassembled Signaling Complexes” at the Plasma Membrane*

  1998cited by this paper
• Episomal Vectors Rapidly and Stably Produce High-Titer Recombinant Retrovirus

  1996cited by this paper
• A rapid in vitro assay for quantitating the invasive potential of tumor cells.

  1987cited by this paper

• Biomimetic Tumour Model Systems for Pancreatic Ductal Adenocarcinoma in Relation to Photodynamic Therapy

  2025cites this paper
• The role of Caveolin-1 in tumor-derived extracellular vesicle biology and its implications

  2025cites this paper
• Orchestrating movement: the role of Caveolin-1 in migration and metastasis

  2025influential citation
• Is there any diagnostic value of serum caveolin-1 levels on the determination of pancreatic adenocarcinoma?

  2024cites this paper
• Cholesterol metabolism in pancreatic cancer and associated therapeutic strategies.

  2024cites this paper
• Nutrient scavenging-fueled growth in pancreatic cancer depends on caveolae-mediated endocytosis under nutrient-deprived conditions

  2024cites this paper
• Caveolae-Associated Molecules, Tumor Stroma, and Cancer Drug Resistance: Current Findings and Future Perspectives

  2022cites this paper
• Autophagic Inhibition of Caveolin-1 by Compound Phyllanthus urinaria L. Activates Ubiquitination and Proteasome Degradation of β-catenin to Suppress Metastasis of Hepatitis B-Associated Hepatocellular Carcinoma

  2021cites this paper
• Prognostic significance and therapeutic implications of Caveolin-1 in gastrointestinal tract malignancies.

  2021cites this paper
• Role of caveolin-1 in human organ function and disease: friend or foe?

  2021cites this paper
• Caveolin‐1 influences epithelial collective cell migration via FMNL2 formin

  2020cites this paper
• Bone marrow mesenchymal stem cells suppress growth and promote the apoptosis of glioma U251 cells through downregulation of the PI3K/AKT signaling pathway.

  2019cites this paper
• Chrysotobibenzyl inhibition of lung cancer cell migration through Caveolin-1-dependent mediation of the integrin switch and the sensitization of lung cancer cells to cisplatin-mediated apoptosis.

  2019cites this paper
• Caveolin-1 enhances brain metastasis of non-small cell lung cancer, potentially in association with the epithelial-mesenchymal transition marker SNAIL

  2019cites this paper
• Integrated analysis of lncRNA CTD-2357A8.3 expression and its potential roles in head and neck squamous cell carcinoma

  2019cites this paper
• LINC81507 act as a competing endogenous RNA of miR-199b-5p to facilitate NSCLC proliferation and metastasis via regulating the CAV1/STAT3 pathway

  2019cites this paper
• The membrane environment of cadherin adhesion receptors: a working hypothesis.

  2019cites this paper
• Jorunnamycin A from Xestospongia sp. Suppresses Epithelial to Mesenchymal Transition and Sensitizes Anoikis in Human Lung Cancer Cells.

  2019cites this paper
• ITGB1-dependent upregulation of Caveolin-1 switches TGFβ signalling from tumour-suppressive to oncogenic in prostate cancer

  2018cites this paper
• Caveolin-1 Inhibits Proliferation, Migration, and Invasion of Human Colorectal Cancer Cells by Suppressing Phosphorylation of Epidermal Growth Factor Receptor

  2018cites this paper
• Caveolin-1 enhances RANKL-induced gastric cancer cell migration

  2018cites this paper
• Silencing of caveolin-1 in fibroblasts as opposed to epithelial tumor cells results in increased tumor growth rate and chemoresistance in a human pancreatic cancer model

  2018cites this paper
• Role of Caveolin-1 in Hypoxia and Proneural to Mesenchymal Transition of Glioblastoma

  2018cites this paper
• The different functions and clinical significances of caveolin-1 in human adenocarcinoma and squamous cell carcinoma

  2017cites this paper
• Decreased Expression of Caveolin-1 and E-Cadherin Correlates with the Clinicopathologic Features of Gastric Cancer and the EMT Process.

  2016cites this paper
• ∆Np73beta induces caveolin-1 in human non-small cell lung cancer cell line H1299

  2016cites this paper
• ATP13A3 and caveolin-1 as potential biomarkers for difluoromethylornithine-based therapies in pancreatic cancers.

  2016cites this paper
• Cross-talk between Dopachrome Tautomerase and Caveolin-1 Is Melanoma Cell Phenotype-specific and Potentially Involved in Tumor Progression*

  2016influential citation
• Mechanical phenotype of cancer cells: cell softening and loss of stiffness sensing

  2015cites this paper
• Involvement of epithelial to mesenchymal transition in the development of pancreatic ductal adenocarcinoma

  2015cites this paper
• Caveolin-1 is essential in the differentiation of human adipose-derived stem cells into hepatocyte-like cells via an MAPK pathway-dependent mechanism

  2015cites this paper
• Adherens Junctions Revisualized: Organizing Cadherins as Nanoassemblies.

  2015cites this paper
• Antimetastatic Activity of Tinospora Cordifolia Involves Inhibition of Cell Migration and Invasion Regulated By Twist and Snail Genes

  2015cites this paper
• Caveolin-1 is a modulator of clonogenicity in renal cell carcinoma

  2015cites this paper
• Caveolin-1 promotes gastric cancer progression by up-regulating epithelial to mesenchymal transition by crosstalk of signalling mechanisms under hypoxic condition.

  2014cites this paper
• miR-133a functions as a tumor suppressor and directly targets FSCN1 in pancreatic cancer.

  2014cites this paper
• Efficacy of gemcitabine conjugated and miRNA-205 complexed micelles for treatment of advanced pancreatic cancer.

  2014cites this paper
• CAV-1 contributes to bladder cancer progression by inducing epithelial-to-mesenchymal transition.

  2014cites this paper
• miR-203 inhibits tumor cell migration and invasion via caveolin-1 in pancreatic cancer cells

  2014cites this paper
• Caveolin-1 deficiency induces a MEK-ERK1/2-Snail-1-dependent epithelial–mesenchymal transition and fibrosis during peritoneal dialysis

  2014cites this paper
• Role of Cancer Stem Cells in Metastasis

  2014cites this paper
• PTRF/Cavin-1 decreases prostate cancer angiogenesis and lymphangiogenesis

  2013cites this paper
• Caveolin and TGF‐β entanglements

  2013cites this paper
• Caveolin-1 controls airway epithelial barrier function. Implications for asthma.

  2013cites this paper
• Dysregulated pH in Tumor Microenvironment Checkmates Cancer Therapy.

  2013cites this paper
• Mechanistic analysis of taxol-induced multidrug resistance in an ovarian cancer cell line.

  2013influential citation
• The expression and functionality of stromal caveolin 1 in human adenomyosis.

  2013cites this paper
• Loss of caveolin-1 promotes endothelial-mesenchymal transition during sepsis: a membrane proteomic study.

  2013cites this paper
• Caveolin-1 as a promoter of tumour spreading: when, how, where and why

  2013cites this paper
• The emerging role of the TGFβ tumor suppressor pathway in pancreatic cancer

  2012cites this paper
• Epithelial-to-mesenchymal transition (EMT) confers primary resistance to trastuzumab (Herceptin)

  2012cites this paper
• Pancreatic stellate cells form a niche for cancer stem cells and promote their self-renewal and invasiveness

  2012cites this paper
• Nectin like-5 overexpression correlates with the malignant phenotype in cutaneous melanoma

  2012cites this paper
• ITGB 1-dependent upregulation of Caveolin-1 switches TGF beta signalling from tumour-suppressive to oncogenic in prostate cancer

  year unknowncites this paper