Analysis of multiple metabolites of tocopherols and tocotrienols in mice and humans.

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Journal of Agricultural and Food Chemistry

• Publication date

  2010-04-28

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1021/jf904464uPMID 20222730PMCID PMC2858244
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Cancer-preventive activities of tocopherols and tocotrienols.

  2010cited by this paper
• Gamma-tocotrienol and gamma-tocopherol are primarily metabolized to conjugated 2-(beta-carboxyethyl)-6-hydroxy-2,7,8-trimethylchroman and sulfated long-chain carboxychromanols in rats.

  2009cited by this paper
• Metabolomics reveals a novel vitamin E metabolite and attenuated vitamin E metabolism upon PXR activation Published, JLR Papers in Press, January 20, 2009.

  2009cited by this paper
• A γ-Tocopherol–Rich Mixture of Tocopherols Inhibits Colon Inflammation and Carcinogenesis in Azoxymethane and Dextran Sulfate Sodium–Treated Mice

  2009cited by this paper
• Long-chain carboxychromanols, metabolites of vitamin E, are potent inhibitors of cyclooxygenases

  2008cited by this paper
• Isolation and identification of alpha-CEHC sulfate in rat urine and an improved method for the determination of conjugated alpha-CEHC.

  2008cited by this paper
• Tocotrienols in health and disease: the other half of the natural vitamin E family.

  2007cited by this paper
• Anti-inflammatory properties of alpha- and gamma-tocopherol.

  2007cited by this paper
• Vitamin E chemistry. Nitration of non-alpha-tocopherols: products and mechanistic considerations.

  2007cited by this paper
• Alpha-tocopherol modulates Cyp3a expression, increases gamma-CEHC production, and limits tissue gamma-tocopherol accumulation in mice fed high gamma-tocopherol diets.

  2005cited by this paper
• Studies in humans using deuterium-labeled alpha- and gamma-tocopherols demonstrate faster plasma gamma-tocopherol disappearance and greater gamma-metabolite production.

  2005cited by this paper
• Biological Functions and Metabolic Fate of Vitamin E Revisited

  2004cited by this paper
• New perspectives on vitamin E: gamma-tocopherol and carboxyelthylhydroxychroman metabolites in biology and medicine.

  2004cited by this paper
• γ-Tocopherol biokinetics and transformation in humans

  2003cited by this paper
• Simultaneous determination of tocotrienols, tocopherols, retinol, and major carotenoids in human plasma.

  2003cited by this paper
• Measurement of vitamin E metabolites by high-performance liquid chromatography during high-dose administration of α-tocopherol

  2003cited by this paper
• Vitamin E and drug metabolism.

  2003cited by this paper
• Gas chromatography mass spectrometry analysis of carboxyethyl-hydroxychroman metabolites of alpha- and gamma-tocopherol in human plasma.

  2002cited by this paper
• Identities and differences in the metabolism of tocotrienols and tocopherols in HepG2 cells.

  2002cited by this paper
• Tocopherol metabolites 2, 5, 7, 8-tetramethyl-2-(2'-carboxyethyl)-6-hydroxychroman (α-CEHC) and 2, 7, 8-trimethyl-2-(2'-carboxyethyl)-6-hydroxychroman (γ-CEHC) in human serum after a single dose of natural vitamin E

  2002cited by this paper
• Three series of high molecular weight alkanoates found in Amazonian plants.

  2002cited by this paper
• Qualitative and quantitative analysis of tocopherols in toothpastes and gingival tissue employing HPLC NMR and HPLC MS coupling.

  2002cited by this paper
• Cytochrome P450 omega-hydroxylase pathway of tocopherol catabolism. Novel mechanism of regulation of vitamin E status.

  2002cited by this paper
• Tocopherols are metabolized in HepG2 cells by side chain omega-oxidation and consecutive beta-oxidation.

  2001cited by this paper
• Novel urinary metabolite of alpha-tocopherol, 2,5,7,8-tetramethyl-2(2'-carboxyethyl)-6-hydroxychroman, as an indicator of an adequate vitamin E supply?

  1995cited by this paper
• The role of metabolism in the antioxidant function of vitamin E.

  1993cited by this paper
• Absorption, transport and metabolism of vitamin E.

  1991cited by this paper
• Novel urinary metabolite of d-delta-tocopherol in rats.

  1984cited by this paper
• The effects of experimental hepatobiliary disease on certain aspects of tocopherol metabolism in the rat.

  1957cited by this paper

• Quantification of tocomonoenols and other tocochromanols in edible plant oils by gas chromatography coupled with mass spectrometry

  2025cites this paper
• Human Vitamin E deficiency, and what is and is not Vitamin E?

  2024cites this paper
• Metabolic profiling of milk thistle different organs using UPLC-TQD-MS/MS coupled to multivariate analysis in relation to their selective antiviral potential

  2024cites this paper
• A New LC-MS/MS-Based Method for the Simultaneous Detection of α-Tocopherol and Its Long-Chain Metabolites in Plasma Samples Using Stable Isotope Dilution Analysis

  2024cites this paper
• Determination of free and bound antioxidants in Kamut® wheat by HPLC with triple detector (DAD-CAD-MS)

  2024cites this paper
• β-Tocotrienol Decreases PDGF-BB-Induced Proliferation and Migration of Human Airway Smooth Muscle Cells by Inhibiting RhoA and Reducing ROS Production

  2024cites this paper
• A new RPLC-ESI-MS method for the determination of eight vitamers of vitamin E.

  2023cites this paper
• Fat-soluble vitamin and phytochemical metabolites: Production, gastrointestinal absorption, and health effects.

  2023cites this paper
• Associations of Vitamins and Related Cofactor Metabolites with Mammographic Breast Density in Premenopausal Women.

  2023cites this paper
• Chemopreventive and anti-tumor potential of vitamin E in preclinical breast cancer studies: A systematic review.

  2022cites this paper
• Vitamin E in foodstuff: Nutritional, analytical, and food technology aspects.

  2022cites this paper
• Enzyme-Mediated Reactions of Phenolic Pollutants and Endogenous Metabolites as an Overlooked Metabolic Disruption Pathway.

  2022cites this paper
• Genetic Variants in Folate and Cobalamin Metabolism-Related Genes in Pregnant Women of a Homogeneous Spanish Population: The Need for Revisiting the Current Vitamin Supplementation Strategies

  2022cites this paper
• Influence of the microbiome, diet and genetics on inter-individual variation in the human plasma metabolome

  2022cites this paper
• Structural diversity, biosynthesis, and health-promoting properties of brown algal meroditerpenoids

  2021cites this paper
• Metabolism of natural forms of vitamin E and biological actions of vitamin E metabolites.

  2021cites this paper
• Endogenous vitamin E metabolites mediate allosteric PPARγ activation with unprecedented co-regulatory interactions.

  2021cites this paper
• Determination of Vitamin E and its Metabolites in Equine Urine Using Liquid Chromatography - Mass Spectrometry.

  2021cites this paper
• α-Tocomonoenol Is Bioavailable in Mice and May Partly Be Regulated by the Function of the Hepatic α-Tocopherol Transfer Protein

  2020cites this paper
• LC-MS/MS quantification of fat soluble vitamers - a systematic review.

  2020cites this paper
• Changes in the Fecal Metabolome Are Associated with Feeding Fiber Not Health Status in Cats with Chronic Kidney Disease

  2020cites this paper
• Diversity of Chromanol and Chromenol Structures and Functions: An Emerging Class of Anti-Inflammatory and Anti-Carcinogenic Agents

  2020cites this paper
• Bioactive constituents, vitamin analysis, antioxidant capacity and α-glucosidase inhibition of Canna indica L. rhizome extracts

  2020cites this paper
• Adsorptive precipitation of vitamin D3 and vitamin E on gum arabic and sodium alginate using supercritical carbon dioxide

  2020cites this paper
• A Facile Semisynthesis and Evaluation of Garcinoic Acid and Its Analogs for the Inhibition of Human DNA Polymerase β

  2020cites this paper
• Synthesis of [18F]F-γ-T-3, a Redox-Silent γ-Tocotrienol (γ-T-3) Vitamin E Analogue for Image-Based In Vivo Studies of Vitamin E Biodistribution and Dynamics

  2020cites this paper
• Genetic Variants Shaping Inter-individual Differences in Response to Dietary Intakes—A Narrative Review of the Case of Vitamins

  2020cites this paper
• Dilute-and-shoot-based direct nano-electrospray ionization tandem mass spectrometry as screening methodology for multivitamins in dietary supplement and human urine

  2020cites this paper
• Influence of linseed and antioxidant-rich diets in pig nutrition on lipid oxidation during cooking and in vitro digestion of pork.

  2020cites this paper
• Vitamin E: Regulatory role in the cardiovascular system

  2019cites this paper
• Vitamin E: Regulatory role of metabolites

  2019cites this paper
• Bioavailability and Metabolism of Vitamin E

  2019cites this paper
• Bioactivity of Vitamin E Long-Chain Metabolites

  2019cites this paper
• Comparison of the microbiome, metabolome, and lipidome of obese and non-obese horses

  2019cites this paper
• Chapter 1 The Hepatic Fate of Vitamin E

  2019cites this paper
• Methods for assessment of Vitamin E

  2019cites this paper
• Phytochemical Diversity in Rhizomes of Three Reynoutria Species and their Antioxidant Activity Correlations Elucidated by LC-ESI-MS/MS Analysis

  2019cites this paper
• Effects of antibiotics on degradation and bioavailability of different vitamin E forms in mice.

  2019cites this paper
• Extraction, purification and nuclear magnetic resonance (NMR) assignment of garcinoic acid from Garcinia kola (bitter kola) fruit

  2018cites this paper
• Ionization of tocopherols and tocotrienols in atmospheric pressure chemical ionization.

  2018cites this paper
• Long-Chain Metabolites of Vitamin E: Metabolic Activation as a General Concept for Lipid-Soluble Vitamins?

  2018cites this paper
• Safety Assessment of Tocopherols and Tocotrienols as Used in Cosmetics

  2018cites this paper
• Ultrafast determination of vitamin E using LC-ESI-MS/MS for preclinical development of new nutraceutical formulations.

  2018cites this paper
• Water-Soluble Vitamin E-Tocopheryl Phosphate.

  2018cites this paper
• The Hepatic Fate of Vitamin E

  2018cites this paper
• Métabolisme des rétinoïdes et facteurs d’influence dans l’obésité, la résistance à l’insuline et le diabète de type 2 : études chez l’animal et chez l’homme

  2018cites this paper
• Vitamin-supplemented chewing gum can increase salivary and plasma levels of a panel of vitamins in healthy human participants

  2018cites this paper
• Bio-analytical screening and characterization of antioxidant compounds using online liquid chromatography techniques and mass spectrometry

  2018cites this paper
• Natural 6-hydroxy-chromanols and -chromenols: structural diversity, biosynthetic pathways and health implications

  2018cites this paper
• The Hepatic Fate of Vitamin E The Hepatic Fate of Vitamin E

  2018cites this paper
• Inhibitory Effects of γ- and δ-Tocopherols on Estrogen-Stimulated Breast Cancer In Vitro and In Vivo

  2017cites this paper
• Vitamin E: Emerging aspects and new directions

  2017cites this paper
• Trace Elements and Antioxidants in Some Medicinal Plants

  2017cites this paper
• Determination of tocopherols and their metabolites by liquid-chromatography coupled with tandem mass spectrometry in human plasma and serum.

  2017cites this paper
• Methods for efficient analysis of tocopherols, tocotrienols and their metabolites in animal samples with HPLC-EC

  2017cites this paper
• Vitamin E (Tocopherols and Tocotrienols) in Fruits and Vegetables with Focus on Chemistry and Biological Activities

  2017cites this paper
• The long chain α–tocopherol metabolite α‐13’‐COOH and γ‐tocotrienol induce P‐glycoprotein expression and activity by activation of the pregnane X receptor in the intestinal cell line LS 180

  2017cites this paper
• Effects of delta-tocotrienol on obesity-related adipocyte hypertrophy, inflammation and hepatic steatosis in high-fat-fed mice.

  2017cites this paper
• More than 170 polyunsaturated tocopherol-related compounds in a vitamin E capsule: Countercurrent chromatographic enrichment, gas chromatography/mass spectrometry analysis and preliminary identification of the potential artefacts.

  2016cites this paper
• Chapter 9 – Garcinoic Acid: A Promising Bioactive Natural Product for Better Understanding the Physiological Functions of Tocopherol Metabolites

  2016cites this paper
• Complexity of vitamin E metabolism.

  2016cites this paper
• GC-MS and LC-MS approaches for determination of tocopherols and tocotrienols in biological and food matrices.

  2016cites this paper
• Recent advances in the determination of tocopherols in biological fluids: from sample pretreatment and liquid chromatography to clinical studies

  2016influential citation
• Tocopherols inhibit oxidative and nitrosative stress in estrogen‐induced early mammary hyperplasia in ACI rats

  2015cites this paper
• Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis.

  2015cites this paper
• Design of lipid-based delivery systems for improving lymphatic transport and bioavailability of delta-tocopherol and nobiletin

  2015cites this paper
• Analysis of vitamin E metabolites including carboxychromanols and sulfated derivatives using LC/MS/MS

  2015cites this paper
• Human serum determination and in vitro anti-inflammatory activity of the vitamin E metabolite α-(13'-hydroxy)-6-hydroxychroman.

  2015cites this paper
• Dietary γ-Tocopherol–Rich Mixture Inhibits Estrogen-Induced Mammary Tumorigenesis by Modulating Estrogen Metabolism, Antioxidant Response, and PPARγ

  2015cites this paper
• Similarities and differences between alpha-tocopherol and gamma-tocopherol in amelioration of inflammation, oxidative stress and pre-fibrosis in hyperglycemia induced acute kidney inflammation

  2015cites this paper
• Scientific Opinion on Dietary Reference Values for vitamin E as α-tocopherol

  2015cites this paper
• Regulation of non-antioxidative and inflammatory pathways in macrophages by long-chain metabolites of α-tocopherol

  2014cites this paper
• Analysis of vitamin e metabolites by liquid chromatography-tandem mass spectrometry

  2014cites this paper
• Regulatory metabolites of vitamin E and their putative relevance for atherogenesis

  2014cites this paper
• Human oral bioavailability and pharmacokinetics of tocotrienols from tocotrienol-rich (tocopherol-low) barley oil and palm oil formulations

  2014cites this paper
• Long-chain metabolites of α-tocopherol occur in human serum and inhibit macrophage foam cell formation in vitro.

  2014cites this paper
• Natural forms of vitamin E: metabolism, antioxidant, and anti-inflammatory activities and their role in disease prevention and therapy.

  2014cites this paper
• The Post-Transcriptional Regulation of Antioxidant Enzymes

  2013cites this paper
• A LC–MS metabolomics approach to investigate the effect of raw apple intake in the rat plasma metabolome

  2013cites this paper
• Dietary tocopherols inhibit cell proliferation, regulate expression of ERα, PPARγ, and Nrf2, and decrease serum inflammatory markers during the development of mammary hyperplasia

  2013cites this paper
• Chemopreventive activity of tocopherols in mammary tumorigenesis

  2013cites this paper
• Mechanisms for the prevention of vitamin E excess

  2013cites this paper
• Inhibitory effects of different forms of tocopherols, tocopherol phosphates, and tocopherol quinones on growth of colon cancer cells.

  2013cites this paper
• Dietary Administration of δ- and γ-Tocopherol Inhibits Tumorigenesis in the Animal Model of Estrogen Receptor–Positive, but not HER-2 Breast Cancer

  2012cites this paper
• Does Vitamin E Prevent or Promote Cancer?

  2012cites this paper
• Do tocotrienols have potential as neuroprotective dietary factors?

  2012cites this paper
• Dietary Administration of d- and g-Tocopherol Inhibits Tumorigenesis in the Animal Model of Estrogen Receptor– Positive, but not HER-2 Breast Cancer

  2012cites this paper
• Disruption of Mouse Cytochrome P450 4f14 (Cyp4f14 Gene) Causes Severe Perturbations in Vitamin E Metabolism*

  2012cites this paper
• The antioxidant and anti-inflammatory activities of tocopherols are independent of Nrf2 in mice.

  2012influential citation
• The identification of vitamin E homologues in medicinal plant samples using ESI(+)-LC-MS3.

  2012cites this paper
• Bioavailability and Metabolism of Tocotrienols

  2012cites this paper
• δ-Tocotrienol: Demethylated Vitamin E with Hormetic Function and Therapeutic Application in Breast Cancer

  2012cites this paper
• The Role Of Vitamin E Hydroxylases In Vitamin E Metabolism And Status

  2012cites this paper
• Disruption of P450-mediated vitamin E hydroxylase activities alters vitamin E status in tocopherol supplemented mice and reveals extra-hepatic vitamin E metabolism

  2012cites this paper
• Metabolism of tocotrienols in animals and synergistic inhibitory actions of tocotrienols with atorvastatin in cancer cells

  2011cites this paper
• δ-Tocopherol Is More Active than α- or γ-Tocopherol in Inhibiting Lung Tumorigenesis In Vivo

  2011cites this paper
• Separation of α-tocotrienol oxidation products and eight tocochromanols by HPLC with DAD and fluorescence detection and identification of unknown peaks by DAD, PBI-EIMS, FTIR, and NMR

  2011cites this paper
• eview o tocotrienols have potential as neuroprotective dietary factors ?

  2011cites this paper
• Cancer-preventive activities of tocopherols and tocotrienols.

  2010cites this paper
• Proapoptotic effects of long-chain vitamin E metabolites in HepG2 cells are mediated by oxidative stress.

  2010cites this paper