Synergistic Effect of Amlodipine and Atorvastatin in Reversing LDL-Induced Endothelial Dysfunction

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Pharmaceutical Research

• Publication date

  2008-08-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1007/s11095-007-9491-1PMID 18087679
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Potential synergy between lipid-lowering and blood-pressure-lowering in the Anglo-Scandinavian Cardiac Outcomes Trial.

  2006cited by this paper
• Intermolecular differences of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors contribute to distinct pharmacologic and pleiotropic actions.

  2005cited by this paper
• Additive Beneficial Effects of Losartan Combined with Simvastatin in the Treatment of Hypercholesterolemic, Hypertensive Patients(Atherosclerosis, Clinical 3 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)

  2005cited by this paper
• Nebivolol Reduces Nitroxidative Stress and Restores Nitric Oxide Bioavailability in Endothelium of Black Americans

  2005cited by this paper
• Primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes in the Collaborative Atorvastatin Diabetes Study (CARDS): multicentre randomised placebo-controlled trial.

  2004cited by this paper
• Short-term statin therapy and cardiac function and symptoms in patients with idiopathic dilated cardiomyopathy.

  2004cited by this paper
• Effects of HMG-CoA Reductase Inhibitors on Endothelial Function: Role of Microdomains and Oxidative Stress

  2004cited by this paper
• An in vitro study of the peroxyl and hydroxyl radical scavenging capacity of the calcium antagonist amlodipine.

  2004cited by this paper
• Effect of antihypertensive agents on cardiovascular events in patients with coronary disease and normal blood pressure: the CAMELOT study: a randomized controlled trial.

  2004cited by this paper
• Effect of Antihypertensive Agents on Cardiovascular Events in Patients With Coronary Disease and Normal Blood Pressure The CAMELOT Study: A Randomized Controlled Trial

  2004cited by this paper
• Additive Beneficial Effects of Losartan Combined With Simvastatin in the Treatment of Hypercholesterolemic, Hypertensive Patients

  2004cited by this paper
• Differential Effects of Amlodipine and Atorvastatin Treatment and Their Combination on Atherosclerosis in ApoE*3‐Leiden Transgenic Mice

  2003cited by this paper
• Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension.

  2003cited by this paper
• Membrane Microdomains and Vascular Biology: Emerging Role in Atherogenesis

  2003cited by this paper
• Endothelium-dependent effects of statins.

  2003cited by this paper
• Novel Vascular Biology of Third-Generation L-Type Calcium Channel Antagonists: Ancillary Actions of Amlodipine

  2003cited by this paper
• Endothelium : Signaling , Oxidative Stress , and Gene Expression

  2003cited by this paper
• Hypercholesterolemia and Hypertension Have Synergistic Deleterious Effects on Coronary Endothelial Function

  2003cited by this paper
• L-4F, an Apolipoprotein A-1 Mimetic, Restores Nitric Oxide and Superoxide Anion Balance in Low-Density Lipoprotein-Treated Endothelial Cells

  2003cited by this paper
• Increased Nitric Oxide Bioavailability in Endothelial Cells Contributes to the Pleiotropic Effect of Cerivastatin

  2002cited by this paper
• Native LDL and minimally oxidized LDL differentially regulate superoxide anion in vascular endothelium in situ.

  2002cited by this paper
• Cellular Antioxidant Effects of Atorvastatin In Vitro and In Vivo

  2002cited by this paper
• Combined effects of systolic blood pressure and serum cholesterol on cardiovascular mortality in young (<55 years) men and women.

  2002cited by this paper
• Cerivastatin potentiates nitric oxide release and enos expression through inhibition of isoprenoids synthesis.

  2002cited by this paper
• Role of p47phox in Vascular Oxidative Stress and Hypertension Caused by Angiotensin II

  2002cited by this paper
• X-ray diffraction analysis of membrane structure changes with oxidative stress.

  2002cited by this paper
• Role of Endothelial Nitric Oxide in Shear Stress—Induced Vasodilation of Human Microvasculature: Diminished Activity in Hypertensive and Hypercholesterolemic Patients

  2001cited by this paper
• Hydroxy-Methylglutaryl–Coenzyme A Reductase Inhibition Promotes Endothelial Nitric Oxide Synthase Activation Through a Decrease in Caveolin Abundance

  2001cited by this paper
• 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibition Prevents Endothelial NO Synthase Downregulation by Atherogenic Levels of Native LDLs: Balance Between Transcriptional and Posttranscriptional Regulation

  2001cited by this paper
• Effect of native and oxidized low-density lipoprotein on endothelial nitric oxide and superoxide production : key role of L-arginine availability.

  2000cited by this paper
• Impaired endothelial function in arterial hypertension and hypercholesterolemia: potential mechanisms and differences

  2000cited by this paper
• Amperometric ultramicrosensors for peroxynitrite detection and its application toward single myocardial cells.

  2000cited by this paper
• Improvement of nitric oxide-dependent vasodilatation by HMG-CoA reductase inhibitors through attenuation of endothelial superoxide anion formation.

  2000cited by this paper
• Interactions between NO and reactive oxygen species: pathophysiological importance in atherosclerosis, hypertension, diabetes and heart failure.

  1999cited by this paper
• Amlodipine releases nitric oxide from canine coronary microvessels: An unexpected mechanism of action of a calcium channel-blocking agent.

  1999cited by this paper
• Membrane antioxidant effects of the charged dihydropyridine calcium antagonist amlodipine.

  1999cited by this paper
• Reduced endothelial nitric oxide synthase expression and production in human atherosclerosis.

  1998cited by this paper
• Endothelium and acute coronary syndromes.

  1998cited by this paper
• Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors.

  1998cited by this paper
• Amlodipine releases nitric oxide from canine coronary microvessels: an unexpected mechanism of action of a calcium channel-blocking agent.

  1998cited by this paper
• Physical effects of cholesterol on arterial smooth muscle membranes: evidence of immiscible cholesterol domains and alterations in bilayer width during atherogenesis.

  1998influential reference
• Atherogenic concentrations of native low-density lipoproteins down-regulate nitric-oxide-synthase mRNA and protein levels in endothelial cells.

  1998cited by this paper
• Sex differences in the abundance of endothelial nitric oxide in a model of genetic hypertension.

  1997cited by this paper
• Cellular and molecular mechanisms of endothelial cell dysfunction.

  1997cited by this paper
• Amperometric sensors for simultaneous superoxide and hydrogen peroxide detection.

  1997cited by this paper
• Effect of age on kinetics of nitric oxide release in rat aorta and pulmonary artery.

  1996cited by this paper
• Reversing endothelial dysfunction with ACE inhibitors. A new trend.

  1996cited by this paper
• Angiotensin-converting enzyme inhibition with quinapril improves endothelial vasomotor dysfunction in patients with coronary artery disease. The TREND (Trial on Reversing ENdothelial Dysfunction) Study.

  1996cited by this paper
• Angiotensin Converting Enzyme Inhibition, with Quinapril, Improves Endothelial Vasomotor Dysfunction in Patients with Coronary Artery Disease: the TREND Study (Trial on REversing ENdothelial Dysfunction)

  1996cited by this paper
• Oxidized Low-density Lipoprotein Decreases the Expression of Endothelial Nitric Oxide Synthase (*)

  1995cited by this paper
• Direct measurement of nitric oxide in human beings.

  1995cited by this paper
• The effect of cholesterol-lowering and antioxidant therapy on endothelium-dependent coronary vasomotion.

  1995cited by this paper
• Native low-density lipoprotein increases endothelial cell nitric oxide synthase generation of superoxide anion.

  1995cited by this paper
• Vasodilation to acetylcholine in primary and secondary forms of human hypertension.

  1993cited by this paper
• Hypercholesterolemia increases endothelial superoxide anion production.

  1993cited by this paper
• Nitric oxide release from a single cell measured in situ by a porphyrinic-based microsensor

  1992cited by this paper
• Serum cholesterol, blood pressure, cigarette smoking, and death from coronary heart disease. Overall findings and differences by age for 316,099 white men. Multiple Risk Factor Intervention Trial Research Group.

  1992cited by this paper
• Serum Cholesterol, Blood Pressure, Cigarette Smoking, and Death From Coronary Heart Disease Overall Findings and Differences by Age for 316099 White Men

  1992cited by this paper
• Conductive polymeric porphyrin films: application in the electrocatalytic oxidation of hydrazine

  1991cited by this paper
• Abnormal endothelium-dependent vascular relaxation in patients with essential hypertension.

  1990cited by this paper
• Partitioning and location of Bay K 8644, 1,4-dihydropyridine calcium channel agonist, in model and biological membranes.

  1989cited by this paper
• Low-density lipoproteins inhibit endothelium-dependent relaxation in rabbit aorta

  1987cited by this paper
• Alterations of Vascular Reactivity in Atherosclerosis

  1987cited by this paper
• Diffusion of dihydropyridine calcium channel antagonists in cardiac sarcolemmal lipid multibilayers.

  1987cited by this paper
• Structure-function studies of canine cardiac sarcolemmal membranes. II. Structural organization of the sarcolemmal membrane as determined by electron microscopy and lamellar X-ray diffraction.

  1985cited by this paper
• Diffusion of univalent ions across the lamellae of swollen phospholipids.

  1965influential reference
• For Personal Use. Only Reproduce with Permission from the Lancet Publishing Group

  year unknowncited by this paper

• From ASCOT to Asia: A More Active and Successful Approach in Preventing Cardiovascular Disease.

  2026cites this paper
• Amlodipine improves aortic dysfunction in atherosclerotic mice.

  2026cites this paper
• Comparative Effectiveness of Novel Combination Therapies for Simultaneous Management of Hypertension and Hypercholesterolemia: A Systematic Review and Meta-Analysis

  2024cites this paper
• Endothelial Nitric Oxide Synthase (eNOS) and the Cardiovascular System: in Physiology and in Disease States

  2022cites this paper
• Comparative efficacy of fixed-dose statin and antihypertensive agent combinations: A network meta-analysis of randomized controlled trials.

  2021cites this paper
• Clinical impact of statin therapy on vasospastic angina: data from a Korea nation-wide cohort study

  2020cites this paper
• Effects of Fimasartan/Amlodipine Fixed-Dose Combination on Left Ventricular Systolic Function and Infarct Size in Rat Myocardial Infarction Model

  2019cites this paper
• Calcium Channel Blockers in Restoration of Endothelial Function: Systematic Review and Meta-Analysis of Randomized Controlled Trials.

  2019cites this paper
• Progressive LDL Reduction to Very Low Levels Improves Dimeric Nitric Oxide Synthase, Nitric Oxide Bioavailability and Reduces Peroxynitrite in Endothelial Cells during Hyperglycemia

  2019cites this paper
• A nanomedical approach to understanding the mechanism of endothelial function and dysfunction-Clinical implications 1

  2019cites this paper
• Eicosapentaenoic acid improves endothelial function and nitric oxide bioavailability in a manner that is enhanced in combination with a statin.

  2018cites this paper
• Cilostazol enhances atorvastatin-induced vasodilation of female rat aorta during aging.

  2017cites this paper
• Amlodipine Ameliorates Ischemia-Induced Neovascularization in Diabetic Rats through Endothelial Progenitor Cell Mobilization

  2016cites this paper
• Az atorvastatin/amlodipin fix kombináció versus az atorvastatinterápia a terápiahűség tükrében

  2016cites this paper
• Formulation, Evaluation and Optimization of Bilayer Tablet of Immediate Release Amlodipine and Sustain Release Atorvastatin

  2016cites this paper
• Nitric Oxide is a Central Common Metabolite in Vascular Dysfunction Associated with Diseases of Human Pregnancy.

  2016cites this paper
• [One year persistence of atorvastatin and amlodipine fixed dose combination versus atorvastatin therapy].

  2016cites this paper
• Atorvastatin enhanced nitric oxide release and reduced blood pressure, nitroxidative stress and rantes levels in hypertensive rats with diabetes.

  2015cites this paper
• Effect of atorvastatin on vascular endothelial function in moderately nicotine-dependent smokers.

  2014cites this paper
• Amlodipine increased endothelial nitric oxide and decreased nitroxidative stress disproportionately to blood pressure changes.

  2014cites this paper
• Effect of atorvastatin on vascular endothelial function in moderately nicotine-dependent smokers.

  2014cites this paper
• Pharmacological prevention of eNOS uncoupling.

  2014cites this paper
• Влияние раннего назначения статинов разных поколений на функциональные возможности сердечно-сосудистой системы при остром инфаркте миокарда

  2014cites this paper
• Thick Ascending Limb Nitric Oxide Production And Inhibition Of Nkcc2 Activity Are Impaired In Angiotensin Ii-Induced Hypertension

  2013cites this paper
• Pacjent z nadciśnieniem tętniczym i dyslipidemią. Znaczenie skojarzonej terapii hipotensyjnej i hipolipemizującej Patients with hypertension and dyslipidemia. The importance of antihypertensive and lipid-lowering combination therapy

  2013cites this paper
• The Anglo-Scandinavian Cardiac Outcomes Trial: Implications and Further Outcomes

  2012cites this paper
• Amlodipine/Atorvastatin

  2012cites this paper
• Pleiotropic Effects of Calcium Channel Blockers

  2012cites this paper
• Role of lipotoxicity in endothelial dysfunction.

  2012cites this paper
• Atorvastatin calcium plus amlodipine for the treatment of hypertension

  2012cites this paper
• Amlodipine ameliorates endothelial dysfunction in mesenteric arteries from spontaneously hypertensive rats

  2011cites this paper
• Effect of Atorvastatin on Angiogenesis in Degenerated Intervertebral Disc in Rat

  2011cites this paper
• Inflammation and the development of atherosclerosis.

  2011cites this paper
• Potent Anti-Ischaemic Effects of Statins in Chronic Stable Angina:Incremental Benefit beyond Lipid Lowering?

  2011cites this paper
• Rapid, Direct Effects of Statin Treatment on Arterial Redox State and Nitric Oxide Bioavailability in Human Atherosclerosis via Tetrahydrobiopterin-Mediated Endothelial Nitric Oxide Synthase Coupling

  2011cites this paper
• Current Therapeutic Strategies to Mitigate the eNOS Dysfunction in Ischaemic Stroke

  2011cites this paper
• Single-pill combination — role in antihypertensive therapy

  2011cites this paper
• Efficacy and Safety of Single-Pill Amlodipine Besylate/Atorvastatin Calcium in the Management of Hypertension and Angina

  2011cites this paper
• Anti-oxidant and anti-inflammatory mechanisms of amlodipine action to improve endothelial cell dysfunction induced by irreversibly glycated LDL.

  2011cites this paper
• Combining antihypertensive and antihyperlipidemic agents – optimizing cardiovascular risk factor management

  2011cites this paper
• Combination of amlodipine and atorvastatin synergistically reduces leukocyte recruitment to mechanically injured mouse femoral artery

  2011cites this paper
• Novel astaxanthin prodrug (CDX-085) attenuates thrombosis in a mouse model.

  2010cites this paper
• Potent anti-ischaemic effects of statins in chronic stable angina: incremental benefit beyond lipid lowering?

  2010cites this paper
• Additive beneficial effects of amlodipine and atorvastatin in reversing advanced cardiac hypertrophy in elderly spontaneously hypertensive rats

  2009cites this paper
• Coadministered amlodipine and atorvastatin produces early improvements in arterial wall compliance in hypertensive patients with dyslipidemia.

  2009cites this paper
• Effet de l'atorvastatine et de l'amlodipine sur le remodelage vasculaire dans l'hypertension

  2009cites this paper
• Kidney Angiotensin II Decreases Nitric Oxide Synthase 3 Expression via Nitric Oxide and Superoxide in the Thick Ascending Limb

  2009cites this paper
• Angiotensin II Decreases Nitric Oxide Synthase 3 Expression via Nitric Oxide and Superoxide in the Thick Ascending Limb

  2009cites this paper
• Treatment with amlodipine and atorvastatin has additive effect on blood and plaque inflammation in hypertensive patients with carotid atherosclerosis.

  2008cites this paper
• eNOS and stroke: prevention, treatment and recovery

  2008cites this paper