Desensitization of μ-opioid receptor-evoked potassium currents: Initiation at the receptor, expression at the effector

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Proceedings of the National Academy of Sciences of the United States of America

• Publication date

  2002-03-26

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1073/pnas.072075399PMID 11917119PMCID PMC123706
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Endocytosis of the mu opioid receptor reduces tolerance and a cellular hallmark of opiate withdrawal.

  2001cited by this paper
• Evolving concepts in G protein-coupled receptor endocytosis: the role in receptor desensitization and signaling.

  2001cited by this paper
• Inhibition of a Gi-activated Potassium Channel (GIRK1/4) by the Gq-coupled m1 Muscarinic Acetylcholine Receptor*

  2001cited by this paper
• Molecular mechanisms and regulation of opioid receptor signaling.

  2000cited by this paper
• Functional Coupling between Neurons and Glia

  2000cited by this paper
• Receptor-mediated hydrolysis of plasma membrane messenger PIP2 leads to K+-current desensitization

  2000cited by this paper
• Activation and inhibition of G protein-coupled inwardly rectifying potassium (Kir3) channels by G protein beta gamma subunits.

  2000cited by this paper
• Downregulation of G protein-coupled receptors.

  2000cited by this paper
• Functional dissociation of mu opioid receptor signaling and endocytosis: implications for the biology of opiate tolerance and addiction.

  1999cited by this paper
• G protein-coupled receptor kinases.

  1998cited by this paper
• Neurotransmitter Activation of Inwardly Rectifying Potassium Current in Dissociated Hippocampal CA3 Neurons: Interactions among Multiple Receptors

  1998cited by this paper
• Presynaptic receptors.

  1998cited by this paper
• Direct activation of inward rectifier potassium channels by PIP2 and its stabilization by Gβγ

  1998cited by this paper
• Evidence that the nucleotide exchange and hydrolysis cycle of G proteins causes acute desensitization of G-protein gated inward rectifier K+ channels.

  1998cited by this paper
• Switching of the coupling of the beta2-adrenergic receptor to different G proteins by protein kinase A.

  1997cited by this paper
• How opioids inhibit GABA-mediated neurotransmission

  1997cited by this paper
• G protein-coupled inwardly rectifying K+ channels (GIRKs) mediate postsynaptic but not presynaptic transmitter actions in hippocampal neurons.

  1997cited by this paper
• Presynaptic inhibitory action of opioids on synaptic transmission in the rat periaqueductal grey in vitro.

  1997cited by this paper
• Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the µ-opioid-receptor gene

  1996cited by this paper
• Opioid desensitization: interactions with G-protein-coupled receptors in the locus coeruleus

  1996cited by this paper
• Opposing mechanisms of regulation of a G-protein-coupled inward rectifier K+ channel in rat brain neurons.

  1995cited by this paper
• Characterization of acute homologous desensitization of μ‐opioid receptor‐induced currents in locus coeruleus neurones

  1995cited by this paper
• Evidence that direct binding of G beta gamma to the GIRK1 G protein-gated inwardly rectifying K+ channel is important for channel activation.

  1995cited by this paper
• Cellular expression of the carboxyl terminus of a G protein-coupled receptor kinase attenuates G beta gamma-mediated signaling.

  1994cited by this paper
• Activation of the cloned muscarinic potassium channel by G protein beta gamma subunits.

  1994cited by this paper
• Opioids mobilize calcium from inositol 1,4,5-trisphosphate-sensitive stores in NG108-15 cells

  1994cited by this paper
• Mechanism of mu‐opioid receptor‐mediated presynaptic inhibition in the rat hippocampus in vitro.

  1993cited by this paper
• Presynaptic inhibition of miniature excitatory synaptic currents by baclofen and adenosine in the hippocampus.

  1992cited by this paper
• Opioid inhibition of GABA release from presynaptic terminals of rat hippocampal interneurons.

  1992cited by this paper
• Transient homologous mu-opioid receptor desensitization in rat locus coeruleus neurons

  1991cited by this paper
• Single potassium channels opened by opioids in rat locus ceruleus neurons.

  1989cited by this paper
• Electrical coupling synchronizes subthreshold activity in locus coeruleus neurons in vitro from neonatal rats

  1989cited by this paper
• Inward rectification of resting and opiate-activated potassium currents in rat locus coeruleus neurons

  1988cited by this paper
• Cellular mechanisms of opioid tolerance: studies in single brain neurons.

  1987cited by this paper
• Neuropharmacology

  1958cited by this paper

• MOPRs in mouse islets of Langerhans modulate cell signaling and secretion

  2025cites this paper
• Emerging modes of regulation of neuromodulatory G protein-coupled receptors.

  2024cites this paper
• Robust GRK2/3/6-dependent desensitization of oxytocin receptor in neurons

  2024cites this paper
• Heterogeneous organization of Locus coeruleus: An intrinsic mechanism for functional complexity.

  2023cites this paper
• A Balancing Act: Learning from the Past to Build a Future-Focused Opioid Strategy.

  2023cites this paper
• Cellular Tolerance Induced by Chronic Opioids in the Central Nervous System

  2022cites this paper
• Endocytic trafficking determines cellular tolerance of presynaptic opioid signaling

  2022influential citation
• Key differences in regulation of opioid receptors localized to presynaptic terminals compared to somas: Relevance for novel therapeutics.

  2022cites this paper
• Opioid suppression of an excitatory pontomedullary respiratory circuit by convergent mechanisms

  2022cites this paper
• G-Protein-Coupled Estrogen Receptor (GPER) in the Rostral Ventromedial Medulla Is Essential for Mobilizing Descending Inhibition of Itch

  2021cites this paper
• One Is Not Enough: Understanding and Modeling Polysubstance Use

  2020cites this paper
• Recent Progress in Opioid Research from an Electrophysiological Perspective

  2020cites this paper
• Electrophysiological Actions of N/OFQ.

  2019cites this paper
• Desensitization and Tolerance of Mu Opioid Receptors on Pontine Kölliker-Fuse Neurons

  2018cites this paper
• Analyzing biased responses of GPCR ligands.

  2017cites this paper
• Enhancement of μ-opioid receptor desensitization by orexin-A in rat locus coeruleus neurons.

  2017cites this paper
• Desensitization-resistant and -sensitive GPCR-mediated inhibition of GABA release occurs by Ca2+-dependent and -independent mechanisms at a hypothalamic synapse.

  2016cites this paper
• Differential Control of Potassium Channel Activity by GRK2

  2016cites this paper
• Visualisation and Perturbation of the Spatio-Temporal Dynamics of Endocytosis

  2015cites this paper
• Spatiotemporal control of opioid signaling and behavior.

  2015cites this paper
• GIRK Channels: A Potential Link Between Learning and Addiction.

  2015cites this paper
• Functional selectivity and time-dependence of μ-opioid receptor desensitization at nerve terminals in the mouse ventral tegmental area

  2014cites this paper
• Regulation of µ-Opioid Receptors: Desensitization, Phosphorylation, Internalization, and Tolerance

  2013cites this paper
• Effects of selective and non-selective inhibitors of nitric oxide synthase on morphine- and endomorphin-1-induced analgesia in acute and neuropathic pain in rats.

  2013cites this paper
• Morphine Desensitization and Cellular Tolerance Are Distinguished in Rat Locus Ceruleus Neurons

  2012cites this paper
• μ-Opioid receptor desensitization: homologous or heterologous?

  2012influential citation
• Prolonged Stimulation of μ-Opioid Receptors Produces β-Arrestin-2-Mediated Heterologous Desensitization of α2-Adrenoceptor Function in Locus Ceruleus Neurons

  2012influential citation
• Multiple Inhibitory G-Protein-Coupled Receptors Resist Acute Desensitization in the Presynaptic But Not Postsynaptic Compartments of Neurons

  2012cites this paper
• Investigating the association between P2X7 receptors, microglia and the actions of morphine

  2011cites this paper
• Role of Kv1 Potassium Channels in Regulating Dopamine Release and Presynaptic D2 Receptor Function

  2011cites this paper
• Plasticity of postsynaptic, but not presynaptic, GABAB receptors in SSADH deficient mice.

  2010influential citation
• Voltage-clamp-based methods for the detection of constitutively active acetylcholine-gated I(K,ACh) channels in the diseased heart.

  2010cites this paper
• Cellular basis for opioid potentiation in the rostral ventromedial medulla of rats with persistent inflammatory nociception

  2010influential citation
• Tolerance to the Antinociceptive Effect of Morphine in the Absence of Short-Term Presynaptic Desensitization in Rat Periaqueductal Gray Neurons

  2010influential citation
• Nonenzymatic rapid control of GIRK channel function by a G protein-coupled receptor kinase.

  2010cites this paper
• How to design an opioid drug that causes reduced tolerance and dependence

  2010cites this paper
• GABAB receptor coupling to G-proteins and ion channels.

  2010cites this paper
• Regulation of Neuronal Chemokine Receptor CXCR4 by μ-Opioid Agonists and Its Involvement in NeuroAIDS

  2010cites this paper
• T-type channels control the opioidergic descending analgesia at the low threshold-spiking GABAergic neurons in the periaqueductal gray

  2010cites this paper
• Regulation of Mu Opioid Receptor Trafficking, Signaling, and Recycling in Neurons

  2009cites this paper
• Cellular neuroadaptations to chronic opioids: tolerance, withdrawal and addiction

  2008cites this paper
• Acute effects of γ-hydroxybutyrate (GHB) : disinhibition of mesolimbic dopamine neurons by specific GIRK subunit assembly

  2008cites this paper
• Kinetic modeling of Na+-induced, Gβγ-dependent activation of G protein-gated K+ channels

  2007cites this paper
• The role of mu opioid receptor desensitization and endocytosis in morphine tolerance and dependence.

  2007cites this paper
• Molecular diversity, trafficking and subcellular localization of GABAB receptors.

  2006cites this paper
• Separation of μ-Opioid Receptor Desensitization and Internalization: Endogenous Receptors in Primary Neuronal Cultures

  2006cites this paper
• Separation of mu-opioid receptor desensitization and internalization: endogenous receptors in primary neuronal cultures.

  2006cites this paper
• Tracking the opioid receptors on the way of desensitization.

  2006cites this paper
• Opioid mu receptor activation inhibits sodium currents in prefrontal cortical neurons via a protein kinase A- and C-dependent mechanism.

  2006cites this paper
• Post-opioid receptor adaptations to chronic morphine; altered functionality and associations of signaling molecules.

  2006cites this paper
• Separation of (cid:1) -Opioid Receptor Desensitization and Internalization: Endogenous Receptors in Primary Neuronal Cultures

  2006cites this paper
• Kinetic modeling of Na(+)-induced, Gbetagamma-dependent activation of G protein-gated K(+) channels.

  2005cites this paper
• Endogenous RGS proteins enhance acute desensitization of GABAB receptor-activated GIRK currents in HEK-293T cells

  2005cites this paper
• Inhibition of neuronal nitric oxide synthase attenuates the development of morphine tolerance in rats

  2005cites this paper
• beta-Arrestin2, interacting with phosphodiesterase 4, regulates synaptic release probability and presynaptic inhibition by opioids.

  2005cites this paper
• Gbetagamma-dependent and Gbetagamma-independent basal activity of G protein-activated K+ channels.

  2005cites this paper
• Morphine-Induced μ-Opioid Receptor Desensitization

  2005cites this paper
• Optimal Agonist/Antagonist Combinations Maintain Receptor Response by Preventing Rapid beta1-Adrenergic Receptor Desensitization

  2005cites this paper
• Gβγ-dependent and Gβγ-independent Basal Activity of G Protein-activated K+ Channels*

  2005cites this paper
• GABA(B) receptor-mediated modulation of synaptic plasticity in the lateral amygdala

  2005cites this paper
• A cell biologist's perspective on physiological adaptation to opiate drugs.

  2004cites this paper
• Redistribution of GABA B(1) Protein and Atypical GABA B Responses in GABA B(2) -Deficient Mice

  2004cites this paper
• Proinflammatory Chemokines, Such as C-C Chemokine Ligand 3, Desensitize μ-Opioid Receptors on Dorsal Root Ganglia Neurons1

  2004cites this paper
• The involvement of α2A-adrenoceptors in morphine analgesia, tolerance and withdrawal in mice

  2004cites this paper
• μ‐Opioid receptor desensitization: Is morphine different?

  2004cites this paper
• Selective Postsynaptic Inhibition of Tonic-firing Neurons in Substantia Gelatinosa by &mgr;-Opioid Agonist

  2004cites this paper
• Mu-opioid receptor desensitization: is morphine different?

  2004cites this paper
• Receptors on Dorsal Root Ganglia Neurons-Opioid μ Chemokine Ligand 3 , Desensitize Proinflammatory Chemokines , Such as C-C

  2004cites this paper
• Chronic Morphine Treatment Reduces Recovery from Opioid Desensitization

  2004influential citation
• Rapid desensitization of G protein-gated inwardly rectifying K(+) currents is determined by G protein cycle.

  2004cites this paper
• The involvement of alpha 2A-adrenoceptors in morphine analgesia, tolerance and withdrawal in mice.

  2004cites this paper
• Redistribution of GABAB(1) Protein and Atypical GABAB Responses in GABAB(2)-Deficient Mice

  2004cites this paper
• Contribution of Kir3.1, Kir3.2A and Kir3.2C subunits to native G protein‐gated inwardly rectifying potassium currents in cultured hippocampal neurons

  2003cites this paper
• Endogenous opiates and behavior: 2002.

  2003cites this paper
• Short-term desensitization of G-protein-activated, inwardly rectifying K+ (GIRK) currents in pyramidal neurons of rat neocortex.

  2003cites this paper
• The Anemone and the Balance

  2003cites this paper
• Opioid Agonists Have Different Efficacy Profiles for G Protein Activation, Rapid Desensitization, and Endocytosis of Mu-opioid Receptors*

  2003cites this paper
• Endothelin-B receptor activation triggers an endogenous analgesic cascade at sites of peripheral injury

  2003cites this paper
• Regulated endocytosis of opioid receptors: cellular mechanisms and proposed roles in physiological adaptation to opiate drugs.

  2003cites this paper
• Phosphoinositide 3-Kinase Cascade Facilitates μ-Opioid Desensitization in Sensory Neurons by Altering G-Protein-Effector Interactions

  2003cites this paper
• [Opiate and opioid tolerance: toxico-kinetic and toxico-dynamic aspects].

  2003cites this paper
• Preventing Rapid Receptor Desensitization at the 1- Adrenergic Receptor with Agonist/Antagonist Combinations

  2003cites this paper
• Two distinct forms of desensitization of G-protein coupled inwardly rectifying potassium currents evoked by alkaloid and peptide mu-opioid receptor agonists.

  2003cites this paper
• GABAB receptor activation desensitizes postsynaptic GABAB and A1 adenosine responses in rat hippocampal neurones

  2002cites this paper