SCIENCE@home

Comparative study and multiple linear regression analysis for assessment of chromatographic behavior of structurally related beta-blockers on different stationary phases.

Ahmed Faried Abdel Hakiem,Ahmed Khairy Hamdy,Ahmed Safwat Aboraia

Published 2019 in Journal of Separation Science

ABSTRACT

A quantitative structure-retention relationship study was performed by thin layer chromatography on a number of β-blockers using 315 molecular descriptors of which nine ones were selected to be the most important physicochemical properties. Those descriptors provide good correlations with chromatographic behavior of the studied structurally related drugs. This research become achieved on three pretreated silica gel plates via impregnation in urea, sodium dodecyl sulfate and dimethylformamide, hence possess varying interplay mechanisms and polarities. The retention parameters were obtained utilizing four solvent systems of two additives of variable ratios, consequently specific polarities in addition to imparted different pH values using either glacial acetic acid or liquid ammonia. Calculated theoretical approaches proves good correlations between investigated descriptors and retention factors. Some correlations show off excellent predicting models, which might be critical for toning better know-how relationships between β-blockers chemical structures and retention. This article is protected by copyright. All rights reserved.

PUBLICATION RECORD

CITATION MAP

EXTRACTION MAP

CLAIMS

  • No claims are published for this paper.

CONCEPTS

  • No concepts are published for this paper.

REFERENCES

Showing 1-40 of 40 references · Page 1 of 1

CITED BY

  • No citing papers are available for this paper.

Showing 0-0 of 0 citing papers · Page 1 of 1